Structural basis of MICAL autoinhibition

Autor: Matej Horvath, Adam Schrofel, Karolina Kowalska, Jan Sabo, Jonas Vlasak, Farahdokht Nourisanami, Margarita Sobol, Daniel Pinkas, Krystof Knapp, Nicola Koupilova, Jiri Novacek, Vaclav Veverka, Zdenek Lansky, Daniel Rozbesky

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract MICAL proteins play a crucial role in cellular dynamics by binding and disassembling actin filaments, impacting processes like axon guidance, cytokinesis, and cell morphology. Their cellular activity is tightly controlled, as dysregulation c

Externí odkaz: https://doaj.org/article/295347d7c6c94b95a4134e3c120c7c7c

Equity in Modifying Plaque of Women With Undertreated Calcified Coronary Artery Disease: Design and Rationale of EMPOWER CAD study

Autor: Margaret McEntegart, MD, Nieves Gonzalo, MD, Lahn Fendelander, MS, Nick E.J. West, MD, Alexandra J. Lansky, MD

Publikováno v: Journal of the Society for Cardiovascular Angiography & Interventions, Vol 3, Iss 11, Pp 102289- (2024)

Background: Coronary artery disease (CAD) is the leading cause of death for women, yet they remain underrepresented in interventional CAD studies. Women have been shown to be at increased risk of mortality and major adverse events after percutaneous

Externí odkaz: https://doaj.org/article/f572f3d9f979466696af30ae84e06c5f

SantaCoder: don't reach for the stars!

Autor: Allal, Loubna Ben, Li, Raymond, Kocetkov, Denis, Mou, Chenghao, Akiki, Christopher, Ferrandis, Carlos Munoz, Muennighoff, Niklas, Mishra, Mayank, Gu, Alex, Dey, Manan, Umapathi, Logesh Kumar, Anderson, Carolyn Jane, Zi, Yangtian, Poirier, Joel Lamy, Schoelkopf, Hailey, Troshin, Sergey, Abulkhanov, Dmitry, Romero, Manuel, Lappert, Michael, De Toni, Francesco, del Río, Bernardo García, Liu, Qian, Bose, Shamik, Bhattacharyya, Urvashi, Zhuo, Terry Yue, Yu, Ian, Villegas, Paulo, Zocca, Marco, Mangrulkar, Sourab, Lansky, David, Nguyen, Huu, Contractor, Danish, Villa, Luis, Li, Jia, Bahdanau, Dzmitry, Jernite, Yacine, Hughes, Sean, Fried, Daniel, Guha, Arjun, de Vries, Harm, von Werra, Leandro

The BigCode project is an open-scientific collaboration working on the responsible development of large language models for code. This tech report describes the progress of the collaboration until December 2022, outlining the current state of the Per

Externí odkaz: http://arxiv.org/abs/2301.03988

BLOOM: A 176B-Parameter Open-Access Multilingual Language Model

Autor: Workshop, BigScience, Scao, Teven Le, Fan, Angela, Akiki, Christopher, Pavlick, Ellie, Ilić, Suzana, Hesslow, Daniel, Castagné, Roman, Luccioni, Alexandra Sasha, Yvon, François, Gallé, Matthias, Tow, Jonathan, Rush, Alexander M., Biderman, Stella, Webson, Albert, Ammanamanchi, Pawan Sasanka, Wang, Thomas, Sagot, Benoît, Muennighoff, Niklas, del Moral, Albert Villanova, Ruwase, Olatunji, Bawden, Rachel, Bekman, Stas, McMillan-Major, Angelina, Beltagy, Iz, Nguyen, Huu, Saulnier, Lucile, Tan, Samson, Suarez, Pedro Ortiz, Sanh, Victor, Laurençon, Hugo, Jernite, Yacine, Launay, Julien, Mitchell, Margaret, Raffel, Colin, Gokaslan, Aaron, Simhi, Adi, Soroa, Aitor, Aji, Alham Fikri, Alfassy, Amit, Rogers, Anna, Nitzav, Ariel Kreisberg, Xu, Canwen, Mou, Chenghao, Emezue, Chris, Klamm, Christopher, Leong, Colin, van Strien, Daniel, Adelani, David Ifeoluwa, Radev, Dragomir, Ponferrada, Eduardo González, Levkovizh, Efrat, Kim, Ethan, Natan, Eyal Bar, De Toni, Francesco, Dupont, Gérard, Kruszewski, Germán, Pistilli, Giada, Elsahar, Hady, Benyamina, Hamza, Tran, Hieu, Yu, Ian, Abdulmumin, Idris, Johnson, Isaac, Gonzalez-Dios, Itziar, de la Rosa, Javier, Chim, Jenny, Dodge, Jesse, Zhu, Jian, Chang, Jonathan, Frohberg, Jörg, Tobing, Joseph, Bhattacharjee, Joydeep, Almubarak, Khalid, Chen, Kimbo, Lo, Kyle, Von Werra, Leandro, Weber, Leon, Phan, Long, allal, Loubna Ben, Tanguy, Ludovic, Dey, Manan, Muñoz, Manuel Romero, Masoud, Maraim, Grandury, María, Šaško, Mario, Huang, Max, Coavoux, Maximin, Singh, Mayank, Jiang, Mike Tian-Jian, Vu, Minh Chien, Jauhar, Mohammad A., Ghaleb, Mustafa, Subramani, Nishant, Kassner, Nora, Khamis, Nurulaqilla, Nguyen, Olivier, Espejel, Omar, de Gibert, Ona, Villegas, Paulo, Henderson, Peter, Colombo, Pierre, Amuok, Priscilla, Lhoest, Quentin, Harliman, Rheza, Bommasani, Rishi, López, Roberto Luis, Ribeiro, Rui, Osei, Salomey, Pyysalo, Sampo, Nagel, Sebastian, Bose, Shamik, Muhammad, Shamsuddeen Hassan, Sharma, Shanya, Longpre, Shayne, Nikpoor, Somaieh, Silberberg, Stanislav, Pai, Suhas, Zink, Sydney, Torrent, Tiago Timponi, Schick, Timo, Thrush, Tristan, Danchev, Valentin, Nikoulina, Vassilina, Laippala, Veronika, Lepercq, Violette, Prabhu, Vrinda, Alyafeai, Zaid, Talat, Zeerak, Raja, Arun, Heinzerling, Benjamin, Si, Chenglei, Taşar, Davut Emre, Salesky, Elizabeth, Mielke, Sabrina J., Lee, Wilson Y., Sharma, Abheesht, Santilli, Andrea, Chaffin, Antoine, Stiegler, Arnaud, Datta, Debajyoti, Szczechla, Eliza, Chhablani, Gunjan, Wang, Han, Pandey, Harshit, Strobelt, Hendrik, Fries, Jason Alan, Rozen, Jos, Gao, Leo, Sutawika, Lintang, Bari, M Saiful, Al-shaibani, Maged S., Manica, Matteo, Nayak, Nihal, Teehan, Ryan, Albanie, Samuel, Shen, Sheng, Ben-David, Srulik, Bach, Stephen H., Kim, Taewoon, Bers, Tali, Fevry, Thibault, Neeraj, Trishala, Thakker, Urmish, Raunak, Vikas, Tang, Xiangru, Yong, Zheng-Xin, Sun, Zhiqing, Brody, Shaked, Uri, Yallow, Tojarieh, Hadar, Roberts, Adam, Chung, Hyung Won, Tae, Jaesung, Phang, Jason, Press, Ofir, Li, Conglong, Narayanan, Deepak, Bourfoune, Hatim, Casper, Jared, Rasley, Jeff, Ryabinin, Max, Mishra, Mayank, Zhang, Minjia, Shoeybi, Mohammad, Peyrounette, Myriam, Patry, Nicolas, Tazi, Nouamane, Sanseviero, Omar, von Platen, Patrick, Cornette, Pierre, Lavallée, Pierre François, Lacroix, Rémi, Rajbhandari, Samyam, Gandhi, Sanchit, Smith, Shaden, Requena, Stéphane, Patil, Suraj, Dettmers, Tim, Baruwa, Ahmed, Singh, Amanpreet, Cheveleva, Anastasia, Ligozat, Anne-Laure, Subramonian, Arjun, Névéol, Aurélie, Lovering, Charles, Garrette, Dan, Tunuguntla, Deepak, Reiter, Ehud, Taktasheva, Ekaterina, Voloshina, Ekaterina, Bogdanov, Eli, Winata, Genta Indra, Schoelkopf, Hailey, Kalo, Jan-Christoph, Novikova, Jekaterina, Forde, Jessica Zosa, Clive, Jordan, Kasai, Jungo, Kawamura, Ken, Hazan, Liam, Carpuat, Marine, Clinciu, Miruna, Kim, Najoung, Cheng, Newton, Serikov, Oleg, Antverg, Omer, van der Wal, Oskar, Zhang, Rui, Zhang, Ruochen, Gehrmann, Sebastian, Mirkin, Shachar, Pais, Shani, Shavrina, Tatiana, Scialom, Thomas, Yun, Tian, Limisiewicz, Tomasz, Rieser, Verena, Protasov, Vitaly, Mikhailov, Vladislav, Pruksachatkun, Yada, Belinkov, Yonatan, Bamberger, Zachary, Kasner, Zdeněk, Rueda, Alice, Pestana, Amanda, Feizpour, Amir, Khan, Ammar, Faranak, Amy, Santos, Ana, Hevia, Anthony, Unldreaj, Antigona, Aghagol, Arash, Abdollahi, Arezoo, Tammour, Aycha, HajiHosseini, Azadeh, Behroozi, Bahareh, Ajibade, Benjamin, Saxena, Bharat, Ferrandis, Carlos Muñoz, McDuff, Daniel, Contractor, Danish, Lansky, David, David, Davis, Kiela, Douwe, Nguyen, Duong A., Tan, Edward, Baylor, Emi, Ozoani, Ezinwanne, Mirza, Fatima, Ononiwu, Frankline, Rezanejad, Habib, Jones, Hessie, Bhattacharya, Indrani, Solaiman, Irene, Sedenko, Irina, Nejadgholi, Isar, Passmore, Jesse, Seltzer, Josh, Sanz, Julio Bonis, Dutra, Livia, Samagaio, Mairon, Elbadri, Maraim, Mieskes, Margot, Gerchick, Marissa, Akinlolu, Martha, McKenna, Michael, Qiu, Mike, Ghauri, Muhammed, Burynok, Mykola, Abrar, Nafis, Rajani, Nazneen, Elkott, Nour, Fahmy, Nour, Samuel, Olanrewaju, An, Ran, Kromann, Rasmus, Hao, Ryan, Alizadeh, Samira, Shubber, Sarmad, Wang, Silas, Roy, Sourav, Viguier, Sylvain, Le, Thanh, Oyebade, Tobi, Le, Trieu, Yang, Yoyo, Nguyen, Zach, Kashyap, Abhinav Ramesh, Palasciano, Alfredo, Callahan, Alison, Shukla, Anima, Miranda-Escalada, Antonio, Singh, Ayush, Beilharz, Benjamin, Wang, Bo, Brito, Caio, Zhou, Chenxi, Jain, Chirag, Xu, Chuxin, Fourrier, Clémentine, Periñán, Daniel León, Molano, Daniel, Yu, Dian, Manjavacas, Enrique, Barth, Fabio, Fuhrimann, Florian, Altay, Gabriel, Bayrak, Giyaseddin, Burns, Gully, Vrabec, Helena U., Bello, Imane, Dash, Ishani, Kang, Jihyun, Giorgi, John, Golde, Jonas, Posada, Jose David, Sivaraman, Karthik Rangasai, Bulchandani, Lokesh, Liu, Lu, Shinzato, Luisa, de Bykhovetz, Madeleine Hahn, Takeuchi, Maiko, Pàmies, Marc, Castillo, Maria A, Nezhurina, Marianna, Sänger, Mario, Samwald, Matthias, Cullan, Michael, Weinberg, Michael, De Wolf, Michiel, Mihaljcic, Mina, Liu, Minna, Freidank, Moritz, Kang, Myungsun, Seelam, Natasha, Dahlberg, Nathan, Broad, Nicholas Michio, Muellner, Nikolaus, Fung, Pascale, Haller, Patrick, Chandrasekhar, Ramya, Eisenberg, Renata, Martin, Robert, Canalli, Rodrigo, Su, Rosaline, Su, Ruisi, Cahyawijaya, Samuel, Garda, Samuele, Deshmukh, Shlok S, Mishra, Shubhanshu, Kiblawi, Sid, Ott, Simon, Sang-aroonsiri, Sinee, Kumar, Srishti, Schweter, Stefan, Bharati, Sushil, Laud, Tanmay, Gigant, Théo, Kainuma, Tomoya, Kusa, Wojciech, Labrak, Yanis, Bajaj, Yash Shailesh, Venkatraman, Yash, Xu, Yifan, Xu, Yingxin, Xu, Yu, Tan, Zhe, Xie, Zhongli, Ye, Zifan, Bras, Mathilde, Belkada, Younes, Wolf, Thomas

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizati

Externí odkaz: http://arxiv.org/abs/2211.05100

Blockchain technology and raft consensus for secure physician prescriptions and improved diagnoses in electronic healthcare systems

Autor: Behnaz Abdorrahimi, Atefeh Nekouie, Amir Masoud Rahmani, Jan Lansky, Vladimír Nulíček, Mehdi Hosseinzadeh, Mohammad Hossein Moattar

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract With electronic healthcare systems undergoing rapid change, optimizing the crucial process of recording physician prescriptions is a task with major implications for patient care. The power of blockchain technology and the precision of the R

Externí odkaz: https://doaj.org/article/220ce27b81da46a2ac5a7988f37776a6