Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Lansing Taylor"'
Autor:
Julio Aleman, Ravikumar K, Connor Wiegand, Mark E. Schurdak, Lawrence Vernetti, Dillon Gavlock, Celeste Reese, Richard DeBiasio, Greg LaRocca, Yulder Daniel Angarita, Albert Gough, Alejandro Soto-Gutierrez, Jaideep Behari, Vijay K. Yechoor, Mark T. Miedel, Andrew M. Stern, Ipsita Banerjee, D. Lansing Taylor
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of T2DM and MASLD. T
Externí odkaz:
https://doaj.org/article/3786b7dd0e8e47af8bbe42c89dff77b0
Autor:
Mengying Xia, Mahboubeh Varmazyad, Iris Pla-Palacín, Dillon C. Gavlock, Richard DeBiasio, Gregory LaRocca, Celeste Reese, Rodrigo M. Florentino, Lanuza A. P. Faccioli, Jacquelyn A. Brown, Lawrence A. Vernetti, Mark Schurdak, Andrew M. Stern, Albert Gough, Jaideep Behari, Alejandro Soto-Gutierrez, D. Lansing Taylor, Mark T. Miedel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a complex, multisystem disorder driven by multiple factors, including genetics
Externí odkaz:
https://doaj.org/article/ee7744aae33d4960a923808275c298d0
Autor:
Zehra N. Kocas-Kilicarslan, Zeliha Cetin, Lanuza A.P. Faccioli, Takashi Motomura, Sriram Amirneni, Ricardo Diaz-Aragon, Rodrigo M. Florentino, Yiyue Sun, Iris Pla-Palacin, Mengying Xia, Mark T. Miedel, Takeshi Kurihara, Zhiping Hu, Alina Ostrowska, Zi Wang, Robert Constantine, Albert Li, D. Lansing Taylor, Jaideep Behari, Alejandro Soto-Gutierrez, Edgar N. Tafaleng
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 1, Pp 67-77 (2024)
Background and Aims: Chronic liver injury that results in cirrhosis and end-stage liver disease (ESLD) causes more than 1 million deaths annually worldwide. Although the impact of genetic factors on the severity of metabolic dysfunction-associated st
Externí odkaz:
https://doaj.org/article/a352c00a654e49048cd6eb2ec5a1d2e4
Autor:
Rodrigo M. Florentino, Kazutoyo Morita, Nils Haep, Takashi Motomura, Ricardo Diaz-Aragon, Lanuza A.P. Faccioli, Alexandra Collin de l’Hortet, Zeliha Cetin, Carla Frau, Lawrence Vernetti, Anna-Klara Amler, Alexander Thomas, Tobias Lam, Lutz Kloke, Kazuki Takeishi, D. Lansing Taylor, Ira J. Fox, Alejandro Soto-Gutierrez
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105503- (2022)
Summary: Advances in cellular engineering, as well as gene, and cell therapy, may be used to produce human tissues with programmable genetically enhanced functions designed to model and/or treat specific diseases. Fabrication of synthetic human liver
Externí odkaz:
https://doaj.org/article/456852f3c07c4362a0ae4b0b01b19d89
Autor:
Fangyuan Chen, Qingya Shi, Fen Pei, Andreas Vogt, Rebecca A Porritt, Gustavo Garcia, Angela C Gomez, Mary Hongying Cheng, Mark E Schurdak, Bing Liu, Stephen Y Chan, Vaithilingaraja Arumugaswami, Andrew M Stern, D Lansing Taylor, Moshe Arditi, Ivet Bahar
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 8, Pp 1-23 (2021)
Abstract Understanding the mechanism of SARS‐CoV‐2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharmacology approach, we identified a set of repurposable and investigational drugs as poten
Externí odkaz:
https://doaj.org/article/7db43c04a84b4afb9367c079ed650876
Autor:
Shikhar Uttam, Andrew M. Stern, Christopher J. Sevinsky, Samantha Furman, Filippo Pullara, Daniel Spagnolo, Luong Nguyen, Albert Gough, Fiona Ginty, D. Lansing Taylor, S. Chakra Chennubhotla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Spatial information in the tumour microenvironment may be exploited to optimise diagnosis, prognosis and therapy. Here, the authors develop a spatial analytics computational and systems pathology platform (SpAn) based on highly multiplexed antibody i
Externí odkaz:
https://doaj.org/article/a43bb54843794cb1bbe267661f6d6f4c
Autor:
Josepmaria Argemi, Maria U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquin Cabezas, Juan J. Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan P. Arab, Meritxell Ventura-Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Odena, Juan L. Gomez, Tomas Aragon, Jose Altamirano, Juan Caballeria, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho-Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark R. Thursz, Jelena Mann, Matias A. Avila, Ramon Bataller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/65a267dd546740ec9b7190c3e67982ab
Autor:
Josepmaria Argemi, Maria U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquin Cabezas, Juan J. Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan P. Arab, Meritxell Ventura-Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Odena, Juan L. Gomez, Tomas Aragon, Jose Altamirano, Juan Caballeria, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho-Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark R. Thursz, Jelena Mann, Matias A. Avila, Ramon Bataller
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or
Externí odkaz:
https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 6, p e1009125 (2021)
Aberrant signaling through insulin (Ins) and insulin-like growth factor I (IGF1) receptors contribute to the risk and advancement of many cancer types by activating cell survival cascades. Similarities between these pathways have thus far prevented t
Externí odkaz:
https://doaj.org/article/5a50932ee04e4320af6e668981cb0eb3
Autor:
Daniel E. Lefever, Mark T. Miedel, Fen Pei, Johanna K. DiStefano, Richard Debiasio, Tong Ying Shun, Manush Saydmohammed, Maria Chikina, Lawrence A. Vernetti, Alejandro Soto-Gutierrez, Satdarshan P. Monga, Ramon Bataller, Jaideep Behari, Vijay K. Yechoor, Ivet Bahar, Albert Gough, Andrew M. Stern, D. Lansing Taylor
Publikováno v:
Metabolites, Vol 12, Iss 6, p 528 (2022)
Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence with a heterogeneous and complex pathophysiology that presents barriers to traditional targeted therapeutic approaches. We describe an integrated quantitative systems pharmacology
Externí odkaz:
https://doaj.org/article/465968be7e9348c68b977f1cf547b02f