Výsledky vyhledávání - "Lannoy Jacques"

Identification of Potent Non-Peptide Somatostatin Antagonists with sst3 Selectivity

Autor: Pierre Roubert, Christophe Thurieau, Dennis Bigg, Lydie Poitout, Christophe Moinet, Jacques Pommier, Pascale Plas, Marie-Odile Contour-Galcera, Lannoy Jacques

Publikováno v: Journal of Medicinal Chemistry. 44:2990-3000

Using a solution-phase parallel synthesis strategy, a series of non-peptide somatostatin analogues were prepared, and their binding affinities to the five human somatostatin receptor subtypes (sst(1-5)) were determined. Imidazolyl derivatives 2 were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f9ae9d01adef3cf3a817c6e6db36f7
https://doi.org/10.1021/jm0108449

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Butyl 2-(4-[1.1'-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain

Autor: Marion Huchet, Jacques Pommier, P. E. Chabrier, Christine Favre-Guilmard, Anne-Marie Liberatore, Lannoy Jacques, Dennis Bigg, Jocelyne Schulz, Michel Auguet, Marie-Anne Barthelemy, Emilia Pawlowski

Publikováno v: Bioorganicmedicinal chemistry letters. 17(6)

A series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31933df397ac20414a19fd88b25cd38a
https://pubmed.ncbi.nlm.nih.gov/17234409

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