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Coumarins as factor XIIa inhibitors: Potency and selectivity improvements using a fragment-based strategy.

Autor: Davoine C; Namur Medicine & Drug Innovation Center (NAMEDIC - NARILIS), University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium; Laboratory for the Analysis of Medicines (LAM), Department of Pharmacy, CIRM, University of Liege, Place Du 20 Août 7, 4000, Liège, Belgium., Traina A; Namur Medicine & Drug Innovation Center (NAMEDIC - NARILIS), University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium., Evrard J; Namur Medicine & Drug Innovation Center (NAMEDIC - NARILIS), University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium., Lanners S; Namur Medicine & Drug Innovation Center (NAMEDIC - NARILIS), University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium., Fillet M; Laboratory for the Analysis of Medicines (LAM), Department of Pharmacy, CIRM, University of Liege, Place Du 20 Août 7, 4000, Liège, Belgium., Pochet L; Namur Medicine & Drug Innovation Center (NAMEDIC - NARILIS), University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium. Electronic address: lionel.pochet@unamur.be.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 05; Vol. 259, pp. 115636. Date of Electronic Publication: 2023 Jul 16.

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Akademický článek

Crystal structures of two alanyl-piperidine analogues.

Autor: Mambourg K; Department of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium., Tumanov N; Department of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium., Henon G; Department of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium., Lanners S; Department of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium., Garcia-Ladona J; Abaxys Therapeutics, Rue du Berceau 91, Villers-la-Ville 1495, Belgium., Wouters J; Department of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium.

Publikováno v: Acta crystallographica. Section E, Crystallographic communications [Acta Crystallogr E Crystallogr Commun] 2021 Oct 13; Vol. 77 (Pt 11), pp. 1095-1098. Date of Electronic Publication: 2021 Oct 13 (Print Publication: 2021).

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Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies.

Autor: Cesar-Rodo, Elena¹ (AUTHOR), Dupouy, Baptiste¹ (AUTHOR), Häberli, Cécile² (AUTHOR) pascal.maeser@swisstph.ch, Strub, Jean-Marc³ (AUTHOR), Williams, David L.⁴ (AUTHOR) david_williams@rush.edu, Mäser, Pascal^2,5 (AUTHOR) matthias.rottmann@swisstph.ch, Rottmann, Matthias² (AUTHOR) jennifer.keiser@swisstph.ch, Keiser, Jennifer^2,5 (AUTHOR), Lanfranchi, Don Antoine¹ (AUTHOR) lanfranchi@unistra.fr, Davioud-Charvet, Elisabeth¹ (AUTHOR) lanfranchi@unistra.fr

Publikováno v: Molecules. Nov2024, Vol. 29 Issue 22, p5268. 22p.

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Synthesis, crystal structure and conformational analysis of an unexpected [1,5]dithiocine product of aminopyridine and thiovanillin.

Autor: Mambourg K; Departement of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium., Bodart L; Departement of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium., Tumanov N; Departement of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium., Lanners S; Departement of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium., Wouters J; Departement of Chemistry, University of Namur, Rue de Bruxelles 61, Namur 5000, Belgium.

Publikováno v: Acta crystallographica. Section C, Structural chemistry [Acta Crystallogr C Struct Chem] 2020 Mar 01; Vol. 76 (Pt 3), pp. 205-211. Date of Electronic Publication: 2020 Feb 07.

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Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase.

Autor: Balti M; NAMEDIC-NARILIS, University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium; Laboratory of Organic Synthesis and Heterocyclic Chemistry, Department of Chemistry, College of Sciences at Tunis, El Manar University, Campus, 1060 Tunis, Tunisia., Plas A; NAMEDIC-NARILIS, University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium., Meinguet C; NAMEDIC-NARILIS, University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium., Haufroid M; NAMEDIC-NARILIS, University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium., Thémans Q; NAMEDIC-NARILIS, University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium., Efrit ML; Laboratory of Organic Synthesis and Heterocyclic Chemistry, Department of Chemistry, College of Sciences at Tunis, El Manar University, Campus, 1060 Tunis, Tunisia., Wouters J; NAMEDIC-NARILIS, University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium., Lanners S; NAMEDIC-NARILIS, University of Namur, 61 Rue de Bruxelles, 5000 Namur, Belgium. Electronic address: steve.lanners@unamur.be.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Aug 01; Vol. 27 (15), pp. 3607-3610. Date of Electronic Publication: 2016 Jun 18.

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