Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Lanlan Shen"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Structural variation heavily influences the molecular landscape of cancer, in part by impacting DNA methylation-mediated transcriptional regulation. Here, using multi-omic datasets involving >2400 pediatric brain and central nervous system t
Externí odkaz:
https://doaj.org/article/ae44959ac48d463aae9d5429902f1c08
Autor:
Li Yang, Xiaomin Chen, Christy Lee, Jiejun Shi, Emily B. Lawrence, Lanjing Zhang, Yumei Li, Nan Gao, Sung Yun Jung, Chad J. Creighton, Jingyi Jessica Li, Ya Cui, Sumimasa Arimura, Yunping Lei, Wei Li, Lanlan Shen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Background Methylation of the p16 promoter resulting in epigenetic gene silencing—known as p16 epimutation—is frequently found in human colorectal cancer and is also common in normal-appearing colonic mucosa of aging individuals. Thus, t
Externí odkaz:
https://doaj.org/article/d10a6307bd33412e88191550ddc155f1
Autor:
Jiejun Shi, Jianfeng Xu, Yiling Elaine Chen, Jason Sheng Li, Ya Cui, Lanlan Shen, Jingyi Jessica Li, Wei Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The global pattern of the mammalian methylome is formed by changes in methylation and demethylation. Here the authors describe a metric methylation concurrence that measures the ratio of unmethylated CpGs inside the partially methylated reads and sho
Externí odkaz:
https://doaj.org/article/f3d9fde93e384899b5a04283a78052d0
Autor:
Najeeha T. Iqbal, Sana Syed, Kamran Sadiq, Marium N. Khan, Junaid Iqbal, Jennie Z. Ma, Fayaz Umrani, Sheraz Ahmed, Elizabeth A. Maier, Lee A. Denson, Yael Haberman, Monica M. McNeal, Kenneth D. R. Setchell, Xueheng Zhao, Shahida Qureshi, Lanlan Shen, Christopher A. Moskaluk, Ta-Chiang Liu, Omer Yilmaz, Donald E. Brown, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, Sean R. Moore, S. Asad Ali
Publikováno v:
BMC Pediatrics, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background Environmental Enteropathy (EE), characterized by alterations in intestinal structure, function, and immune activation, is believed to be an important contributor to childhood undernutrition and its associated morbidities, includin
Externí odkaz:
https://doaj.org/article/0414bfb214f044bf863c410800397858
Autor:
Jeremy M Schraw, Teresa T Yiu, Philip J Lupo, Spiridon Tsavachidis, Rachel Rau, Melissa L Bondy, Karen R Rabin, Lanlan Shen, Michael E Scheurer
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197408 (2018)
BACKGROUND:There is evidence that maternal genotypes in folate-related genes are associated with pediatric acute lymphoblastic leukemia (ALL) independent of offspring genotype. We evaluated the relationship between maternal genotypes in methionine sy
Externí odkaz:
https://doaj.org/article/747f36ef41794ad2b53f2c5769e2367a
Autor:
Lanlan Shen, Yutaka Kondo, Yi Guo, Jiexin Zhang, Li Zhang, Saira Ahmed, Jingmin Shu, Xinli Chen, Robert A Waterland, Jean-Pierre J Issa
Publikováno v:
PLoS Genetics, Vol 3, Iss 10, Pp 2023-2036 (2007)
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal peripheral blood by methylated Cp
Externí odkaz:
https://doaj.org/article/bf8684fee02a42e087c6ac1b5b7a1992
Publikováno v:
BioTechniques, Vol 42, Iss 1, Pp 48-58 (2007)
Externí odkaz:
https://doaj.org/article/8125a2d7e26f4fe39638d116797296a2
Publikováno v:
Canadian Journal of Gastroenterology, Vol 14, Iss 1, Pp 57-61 (2000)
Advantages and disadvantages of viral vectors and nonviral vectors for gene delivery to digestive organs are reviewed. Advances in systems for the introduction of new gene expression are described, including self-deleting retroviral transfer vectors,
Externí odkaz:
https://doaj.org/article/264ed0cb260840feb442e0a28ca150a8
Autor:
Yoshiyuki Watanabe, Ryan J Castoro, Hyun Soo Kim, Brittany North, Ritsuko Oikawa, Tetsuya Hiraishi, Saira S Ahmed, Woonbok Chung, Mee-Yon Cho, Minoru Toyota, Fumio Itoh, Marcos R H Estecio, Lanlan Shen, Jaroslav Jelinek, Jean-Pierre J Issa
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23320 (2011)
BACKGROUND:MLL3 is a histone 3-lysine 4 methyltransferase with tumor-suppressor properties that belongs to a family of chromatin regulator genes potentially altered in neoplasia. Mutations in MLL3 were found in a whole genome analysis of colorectal c
Externí odkaz:
https://doaj.org/article/232bda65981d441ba17a970c9444e07c
Autor:
Kazuo Konishi, Yoshiyuki Watanabe, Lanlan Shen, Yi Guo, Ryan J Castoro, Kimie Kondo, Woonbok Chung, Saira Ahmed, Jaroslav Jelinek, Yanis A Boumber, Marcos R Estecio, Shinji Maegawa, Yutaka Kondo, Fumio Itoh, Michio Imawari, Stanley R Hamilton, Jean-Pierre J Issa
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27889 (2011)
The contribution of DNA methylation to the metastatic process in colorectal cancers (CRCs) is unclear.We evaluated the methylation status of 13 genes (MINT1, MINT2, MINT31, MLH1, p16, p14, TIMP3, CDH1, CDH13, THBS1, MGMT, HPP1 and ERα) by bisulfite-
Externí odkaz:
https://doaj.org/article/87da15e0342a44f18efe02cb6e7523ad