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Akademický článek

Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation

Autor: Zongji Zhuo, Zhao Wang, Lanlan Jing, Tao Zhang, Anchao Ge, Zhenzhen Zhou, Ying Liu, Xin Li, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 16, p 9028 (2024)

Inspired by our previous work on the modification of diarylpyrimidine-typed non-nucleoside reverse transcriptase inhibitors (NNRTIs) and the reported crystallographic studies, a series of novel amino acids (analogues)-substituted thiophene[3,2-d]pyri

Externí odkaz: https://doaj.org/article/6edd3910ff24434aa0d574a7696157ad

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Akademický článek

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Autor: Shenghua Gao, Letian Song, Hongtao Xu, Antonios Fikatas, Merel Oeyen, Steven De Jonghe, Fabao Zhao, Lanlan Jing, Dirk Jochmans, Laura Vangeel, Yusen Cheng, Dongwei Kang, Johan Neyts, Piet Herdewijn, Dominique Schols, Peng Zhan, Xinyong Liu

Publikováno v: Molecules, Vol 28, Iss 1, p 160 (2022)

The Coronavirus Disease 2019 (COVID-19) and dengue fever (DF) pandemics both remain to be significant public health concerns in the foreseeable future. Anti-SARS-CoV-2 drugs and vaccines are both indispensable to eliminate the epidemic situation. Her

Externí odkaz: https://doaj.org/article/89b6753f327840d6a40932bf3754e640

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Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Publikováno v: Molecules; Volume 28; Issue 1; Pages: 160

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dab3f9b3c3f2ed8cbf75985fbb973cc
https://lirias.kuleuven.be/handle/20.500.12942/711110

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Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs

Autor: Yanying Sun, Zhenzhen Zhou, Da Feng, Lanlan Jing, Fabao Zhao, Zhao Wang, Tao Zhang, Hao Lin, Hao Song, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang

Publikováno v: Journal of medicinal chemistry. 65(23)

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent an indispensable part of anti-HIV-1 therapy. To discover novel HIV-1 NNRTIs with increased drug resistance profiles and improved pharmacokinetic (PK) properties, a series of novel dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09802dd00f020ee835dc685b22e8d017
https://pubmed.ncbi.nlm.nih.gov/36411036

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Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies

Autor: Lanlan Jing, Wenxiu Wei, Bairu Meng, Fabien Chantegreil, Florian Nachon, Ana Martínez, Gaochan Wu, Huajun Zhao, Yuning Song, Dongwei Kang, Xavier Brazzolotto, Peng Zhan, Xinyong Liu

Publikováno v: Bioorganic Chemistry. 134:106465

22 p.-9 fig.-8 tab.
Butyrylcholinesterase is regarded as a promising drug target in advanced Alzheimer’s disease. In order to identify highly selective and potent BuChE inhibitors, a 53-membered compound library was constructed via the oxime-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b9c37da1f0d6ceb8d056d47cbbb30b
https://doi.org/10.1016/j.bioorg.2023.106465

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Fsp3: A new parameter for drug-likeness

Autor: Srinivasulu Cherukupalli, Xinyong Liu, Wei Wenxiu, Peng Zhan, Lanlan Jing

Publikováno v: Drug Discovery Today. 25:1839-1845

The drug-likeness of a compound is a key factor during the initial phases of drug discovery. It can be defined as the similarity between compounds and drugs. Here, we collate research related to the fraction of sp3 carbon atoms (Fsp3), including rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d50c7d426c155aea5226d6d75be934
https://doi.org/10.1016/j.drudis.2020.07.017

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Development of Novel Dihydrofuro[3,4

Autor: Dongwei, Kang, Yanying, Sun, Da, Feng, Shenghua, Gao, Zhao, Wang, Lanlan, Jing, Tao, Zhang, Xiangyi, Jiang, Hao, Lin, Erik, De Clercq, Christophe, Pannecouque, Peng, Zhan, Xinyong, Liu

Publikováno v: Journal of medicinal chemistry. 65(3)

Here, we report the design, synthesis, structure-activity relationship studies, antiviral activity, enzyme inhibition, and druggability evaluation of dihydrofuro[3,4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eef881564d629afc21745976d208caf2
https://pubmed.ncbi.nlm.nih.gov/35061384

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Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C

Autor: Dongwei Kang, Yanying Sun, Da Feng, Shenghua Gao, Zhao Wang, Lanlan Jing, Tao Zhang, Xiangyi Jiang, Hao Lin, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu

Here, we report the design, synthesis, structure-activity relationship studies, antiviral activity, enzyme inhibition, and druggability evaluation of dihydrofuro[3,4-d]pyrimidine derivatives as a potent class of HIV-1 non-nucleoside reverse transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54869a1b7f66f98b0a1aebb66d2f482
https://lirias.kuleuven.be/handle/20.500.12942/703960

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