ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes.

Autor: Kostina A; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lewis-Israeli YR; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Abdelhamid M; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Division of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Gabalski MA; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Volmert BD; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lankerd H; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Huang AR; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Wasserman AH; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA., Lydic T; Department of Physiology, Michigan State University, MI, USA., Chan C; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA.; Department of Chemical Engineering and Materials Science, Michigan State University, MI, USA., Olomu I; Division of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Aguirre A; Division of Developmental and Stem Cell Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.; Department of Biomedical Engineering, College of Engineering, Michigan State University, East Lansing, MI, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 08. Date of Electronic Publication: 2023 Jun 08.