Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution.

Autor: Langthaler, Kristine¹ (AUTHOR) KRIE@lundbeck.com, Jones, Christopher R.² (AUTHOR), Saaby, Lasse³ (AUTHOR), Bundgaard, Christoffer⁴ (AUTHOR), Brodin, Birger⁵ (AUTHOR)

Publikováno v: Fluids & Barriers of the CNS. 1/25/2024, Vol. 21 Issue 1, p1-15. 15p.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

Autor: Ozgür, Burak, Saaby, Lasse, Langthaler, Kristine, Brodin, Birger

Publikováno v: In European Journal of Pharmaceutical Sciences 15 January 2018 112:112-121

Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

Autor: Nielsen, Simone S E, Holst, Mikkel R, Langthaler, Kristine, Christensen, Sarah Christine, Bruun, Elisabeth Helena, Brodin, Birger, Nielsen, Morten S

Publikováno v: Nielsen, S S E, Holst, M R, Langthaler, K, Bruun, E H, Brodin, B & Nielsen, M S 2023, ' Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells ', Fluids and Barriers of the CNS, vol. 20, no. 1, 2 . https://doi.org/10.1186/s12987-022-00404-1
Nielsen, S S E, Holst, M R, Langthaler, K, Christensen, S C, Bruun, E H, Brodin, B & Nielsen, M S 2023, ' Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells ', Fluids and Barriers of the CNS, vol. 20, no. 1, 2 . https://doi.org/10.1186/s12987-022-00404-1

The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the CNS-protective blood–brain barrier constitute an important knowledge gap within maintenance and re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a20208770ed7e5039e7928a39b8cc0b
https://curis.ku.dk/ws/files/332687129/Fulltext.pdf

Practical Application of Rodent Transporter Knockout Models to Assess Brain Penetration in Drug Discovery

Autor: Eneberg, Elin, Jones, Christopher R., Jensen, Thomas, Langthaler, Kristine, Bundgaard, Christoffer

Publikováno v: Drug Metabolism and Bioanalysis Letters; 2022, Vol. 15 Issue: 1 p12-21, 10p