Zobrazeno 1 - 10 of 113 pro vyhledávání: '"Langron, E."'
1
Discovery of Multi-Target Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) for Associated Pulmonary Diseases
Autor: Tassini, S., Mirabelli, C., Neyts, J., Pieroni, M., Cavalli, A., Costantino, G., Maga, G., Vergani, P., Leyssen, P., Radi, M., Sun, L., Lanko, K., Crespan, E., Langron, E., Falchi, F., Kissova, M., Armijos-Rivera, J. I., Delang, L.
Publikováno v: Journal of Medicinal Chemistry (2017) (In press).
UCL Discovery
Enteroviruses (EVs) are among the most frequent infectious agents in humans worldwide and represent the leading cause of upper respiratory tract infections. No drugs for the treatment of EV infections are currently available. Recent studies have also
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______322::74d5ce389e053b3a927b5626e475954a
http://discovery.ucl.ac.uk/1537559/1/acs%2Ejmedchem%2E6b01521.pdf
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2
Dissertation/ Thesis
Drug-discovery tools for cystic fibrosis : optical probes to quantify gating and trafficking of ΔF508-CFTR
Autor: Langron, E.
Cystic fibrosis (CF) is a debilitating disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which codes for the CFTR anion channel. ΔF508, the most common CF-associated mutation, causes both a gating an
Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746377
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3
Akademický článek
From the "One-Molecule, One-Target, One-Disease" Concept towards Looking for Multi-Target Therapeutics for Treating Non-Polio Enterovirus (NPEV) Infections.
Autor: Roux, Hugo1 (AUTHOR) hugo.roux@univ-amu.fr, Touret, Franck2 (AUTHOR) franck.touret@univ-amu.fr, Rathelot, Pascal1 (AUTHOR) pascal.rathelot@univ-amu.fr, Vanelle, Patrice1 (AUTHOR) patrice.vanelle@univ-amu.fr, Roche, Manon1 (AUTHOR) patrice.vanelle@univ-amu.fr
Publikováno v: Pharmaceuticals (14248247). Sep2024, Vol. 17 Issue 9, p1218. 41p.
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4
Akademický článek
Fluorescence assay for simultaneous quantification of CFTR ion-channel function and plasma membrane proximity.
Autor: Prins S; Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom., Langron E; Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom., Hastings C; CoMPLEX, University College London, London, United Kingdom., Hill EJ; Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom., Stefan AC; Natural Sciences, University College London, London, United Kingdom., Griffin LD; CoMPLEX, University College London, London, United Kingdom., Vergani P; Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom. Electronic address: p.vergani@ucl.ac.uk.
Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 Dec 04; Vol. 295 (49), pp. 16529-16544. Date of Electronic Publication: 2020 Sep 15.
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5
Akademický článek
Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach †.
Autor: Tassini S; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Viale delle Scienze, 27/A , 43124 Parma , Italy., Langron E; Department of Neuroscience, Physiology and Pharmacology , University College London , Gower Street , WC1E 6BT London , U.K., Delang L; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research , KU Leuven , Minderbroedersstraat 10 , 3000 Leuven , Belgium., Mirabelli C; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research , KU Leuven , Minderbroedersstraat 10 , 3000 Leuven , Belgium., Lanko K; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research , KU Leuven , Minderbroedersstraat 10 , 3000 Leuven , Belgium., Crespan E; Istituto di Genetica Molecolare, IGM-CNR , Via Abbiategrasso 207 , 27100 Pavia , Italy., Kissova M; Istituto di Genetica Molecolare, IGM-CNR , Via Abbiategrasso 207 , 27100 Pavia , Italy., Tagliavini G; Istituto di Genetica Molecolare, IGM-CNR , Via Abbiategrasso 207 , 27100 Pavia , Italy., Fontò G; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Viale delle Scienze, 27/A , 43124 Parma , Italy., Bertoni S; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Viale delle Scienze, 27/A , 43124 Parma , Italy., Palese S; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Viale delle Scienze, 27/A , 43124 Parma , Italy., Giorgio C; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Viale delle Scienze, 27/A , 43124 Parma , Italy., Ravanetti F; Dipartimento di Scienze Medico-Veterinarie , Università degli Studi di Parma , Via del Taglio 10 , 43126 Parma , Italy., Ragionieri L; Dipartimento di Scienze Medico-Veterinarie , Università degli Studi di Parma , Via del Taglio 10 , 43126 Parma , Italy., Zamperini C; Lead Discovery Siena S.r.l. , Via Vittorio Alfieri 31 , Castelnuovo Berardenga, 53019 Siena , Italy., Mancini A; Dipartimento Biotecnologie, Chimica e Farmacia , Università degli Studi di Siena , 53100 Siena , Italy., Dreassi E; Dipartimento Biotecnologie, Chimica e Farmacia , Università degli Studi di Siena , 53100 Siena , Italy., Maga G; Istituto di Genetica Molecolare, IGM-CNR , Via Abbiategrasso 207 , 27100 Pavia , Italy., Vergani P; Department of Neuroscience, Physiology and Pharmacology , University College London , Gower Street , WC1E 6BT London , U.K., Neyts J; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research , KU Leuven , Minderbroedersstraat 10 , 3000 Leuven , Belgium., Radi M; Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Viale delle Scienze, 27/A , 43124 Parma , Italy.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Dec 12; Vol. 62 (23), pp. 10833-10847. Date of Electronic Publication: 2019 Dec 03.
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6
Akademický článek
Novel drugs affecting diabetic peripheral neuropathy.
Autor: Saleh, Dalia O.1, Sedik, Ahmed A.1 aa.sedik@gmail.com
Publikováno v: Iranian Journal of Basic Medical Sciences. Jun2024, Vol. 27 Issue 6, p657-670. 14p.
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7
Akademický článek
Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydrolytic, O 1 state.
Autor: Langron E; Neuroscience, Physiology and Pharmacology, University College London, London, UK., Prins S; Neuroscience, Physiology and Pharmacology, University College London, London, UK., Vergani P; Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Publikováno v: British journal of pharmacology [Br J Pharmacol] 2018 Oct; Vol. 175 (20), pp. 3990-4002. Date of Electronic Publication: 2018 Sep 16.
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8
Akademický článek
Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds.
Autor: Langron E; Research Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK., Simone MI; Discipline of Chemistry, School of Environmental and Life Sciences, Priority Research Centre for Chemical Biology and Clinical Pharmacology, The University of Newcastle, Callaghan, NSW, Australia., Delalande CM; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Reymond JL; Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland., Selwood DL; Wolfson Institute for Biomedical Research, University College London, London, UK., Vergani P; Research Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Publikováno v: British journal of pharmacology [Br J Pharmacol] 2017 Apr; Vol. 174 (7), pp. 525-539. Date of Electronic Publication: 2017 Feb 14.
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9
Akademický článek
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.
Autor: Tassini S; P4T Group, Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma , Viale delle Scienze, 27/A, 43124 Parma, Italy., Sun L; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, 3000, Leuven, Belgium., Lanko K; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, 3000, Leuven, Belgium., Crespan E; Istituto di Genetica Molecolare , IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy., Langron E; Department of Neuroscience, Physiology and Pharmacology, University College London , Gower Street, WC1E 6BT London, U.K., Falchi F; CompuNet, Istituto Italiano di Tecnologia , Via Morego 30, I-16163 Genova, Italy.; Department of Pharmacy and Biotechnology, University of Bologna , Via Belmeloro 6, I-40126 Bologna, Italy., Kissova M; Istituto di Genetica Molecolare , IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy., Armijos-Rivera JI; Istituto di Genetica Molecolare , IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy., Delang L; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, 3000, Leuven, Belgium., Mirabelli C; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, 3000, Leuven, Belgium., Neyts J; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, 3000, Leuven, Belgium., Pieroni M; P4T Group, Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma , Viale delle Scienze, 27/A, 43124 Parma, Italy., Cavalli A; CompuNet, Istituto Italiano di Tecnologia , Via Morego 30, I-16163 Genova, Italy.; Department of Pharmacy and Biotechnology, University of Bologna , Via Belmeloro 6, I-40126 Bologna, Italy., Costantino G; P4T Group, Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma , Viale delle Scienze, 27/A, 43124 Parma, Italy., Maga G; Istituto di Genetica Molecolare , IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy., Vergani P; Department of Neuroscience, Physiology and Pharmacology, University College London , Gower Street, WC1E 6BT London, U.K., Leyssen P; Laboratory of Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven , Minderbroedersstraat 10, 3000, Leuven, Belgium., Radi M; P4T Group, Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma , Viale delle Scienze, 27/A, 43124 Parma, Italy.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Feb 23; Vol. 60 (4), pp. 1400-1416. Date of Electronic Publication: 2017 Feb 10.
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10
Akademický článek
Involvement of microglial P2X7 receptor in pain modulation.
Autor: Zhang, Jing1 (AUTHOR), Gao, Lei1 (AUTHOR), Zhang, Yaoyuan1 (AUTHOR), Wang, Haozhen1 (AUTHOR), Sun, Shukai1 (AUTHOR) sunshukai0910@163.com, Wu, Li‐an1 (AUTHOR) lianwu@fmmu.edu.cn
Publikováno v: CNS Neuroscience & Therapeutics. Jan2024, Vol. 30 Issue 1, p1-11. 11p.
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