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Akademický článek

Commitment to cytokinetic furrowing requires the coordinate activity of microtubules and Plk1.

Autor: Day CA, Langfald A, Lukes T, Middlebrook H, Vaughan KT, Daniels D, Hinchcliffe EH

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.

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H3F3A K27M Mutations Drives a Repressive Transcriptome by Modulating Chromatin Accessibility, Independent of H3K27me3 in Diffuse Midline Glioma.

Autor: Bhattarai S, Hakkim FL, Day CA, Grigore F, Langfald A, Entin I, Hinchcliffe EH, Robinson JP

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 18. Date of Electronic Publication: 2024 May 18.

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Supplemental Figure 2 from Kaempferol Targets RSK2 and MSK1 to Suppress UV Radiation-Induced Skin Cancer

Autor: Zigang Dong, Ziming Dong, Ann M. Bode, Wei-Ya Ma, Hong-Gyum Kim, Ki Beom Bae, Haitao Li, Mee-Hyun Lee, Myoung Ok Kim, Dong Hoon Yu, Yi Zhang, Ge Yang, Alyssa Langfald, Kangdong Liu, Hanyong Chen, Ke Yao

RSK2 and MSK1 play an important role in Ras-mediated foci formation. A focus formation assay was performed by introducing combinations of vectors as indicated. Foci were stained with 0.5% crystal violet and counted under a microscope using the Image-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15677a86d1ba0ee2391c82dd00df3a1a
https://doi.org/10.1158/1940-6207.22524797.v1

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Supplemental Figure 1 from Kaempferol Targets RSK2 and MSK1 to Suppress UV Radiation-Induced Skin Cancer

SUV induces MAP kinase phosphorylation in JB6 P+ mouse epidermal skin cells in a time- or dose-dependent manner. (A) JB6 P+ cells were cultured, treated with SUV (60 kJ/m2) and harvested at the times indicated (0, 15, 30, 60, or 120 min). (B) JB6 P+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3f189fdc0fb4fc31953e00c147c161
https://doi.org/10.1158/1940-6207.22524800

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Data from Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K

Autor: Ann M. Bode, Zigang Dong, Clinton J. Grubbs, Ronald A. Lubet, Alyssa Langfald, Hanyong Chen, Zunnan Huang, Do Young Lim, Jong-Eun Kim, Mi-Sung Kim

Naproxen [(S)-6-methoxy-α-methyl-2-naphthaleneacetic acid] is a potent nonsteroidal anti-inflammatory drug that inhibits both COX-1 and COX-2 and is widely used as an over-the-counter medication. Naproxen exhibits analgesic, antipyretic, and anti-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::120991de87b7420b891ab18aedf25879
https://doi.org/10.1158/1940-6207.c.6544593

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Supplemental Figure 3 from Kaempferol Targets RSK2 and MSK1 to Suppress UV Radiation-Induced Skin Cancer

(A) Kinase screening assays were conducted by Millipore's KinaseProfiler according to their established protocols. Scores represent the percent of control, which was derived from the following formula: % of control = [(sample âˆ’ mean no enzyme)/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057d18df944fd7ed07078cd1de184a64
https://doi.org/10.1158/1940-6207.22524794.v1

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Supplementary Figure 1 from Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K

Autor: Ann M. Bode, Zigang Dong, Clinton J. Grubbs, Ronald A. Lubet, Alyssa Langfald, Hanyong Chen, Zunnan Huang, Do Young Lim, Jong-Eun Kim, Mi-Sung Kim

PDF file - 85K, The effect of naproxen on JNK1 (A), Akt1 (B), Akt2 (C) and Src (D) kinase activities. Active JNK1 (20 ng), Akt1 (50 ng), Akt2 (50 ng) or Src (400 ng) was mixed with naproxen (0, 0.5, 1 or 2 mM) and then incubated with gamma-32P ATP. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b215b4cf9fd435f091eec638aa0b13c9
https://doi.org/10.1158/1940-6207.22525140.v1

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CCRG-02. THE DIFFUSE MIDLINE GLIOMA MUTATIONS, H3.3 K27M AND G34R/V, INHIBIT MITOTIC PHOSPHORYLATION OF SERINE 31, LEADING TO TUMOR FORMATION THROUGH INCREASED CHROMOSOMAL INSTABILITY

Autor: Charles Day, Florina Grigore, Alyssa Langfald, Faruck Hakkim, David Daniels, Kevin Vaughan, James Robinson, Edward Hincliffe

Publikováno v: Neuro-Oncology. 24:vii37-vii38

Diffuse midline gliomas (DMG) are high-grade pediatric gliomas that frequently harbor heterozygous histone H3.3 K27M, G34R, or G34V mutations. These mutations alter histone methylations, although the precise mechanism(s) of gliomagenesis remains unce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05d821ade51e299fd7e235b86b86b9a6
https://doi.org/10.1093/neuonc/noac209.147

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