Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome.

Autor: Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. Electronic address: christoph.engel@imise.uni-leipzig.de., Ahadova A; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Seppälä TT; Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland; University of Helsinki, Helsinki, Finland; Johns Hopkins University, Surgical Oncology, Baltimore, Maryland., Aretz S; Institute of Human Genetics, University of Bonn, Bonn, Germany; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany., Bigirwamungu-Bargeman M; Department of Gastroenterology & Hepatology, Medisch Spectrum Hospital, Enschede, The Netherlands., Bläker H; Institute of Pathology, University Hospital Leipzig, Leipzig, Germany., Bucksch K; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Büttner R; Institute of Pathology, University of Cologne, Cologne, Germany., de Vos Tot Nederveen Cappel WT; Department of Gastroenterology & Hepatology, Isala Zwolle, Zwolle, The Netherlands., Endris V; Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Holinski-Feder E; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany; Center of Medical Genetics, Munich, Germany., Holzapfel S; Institute of Human Genetics, University of Bonn, Bonn, Germany; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany., Hüneburg R; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Jacobs MAJM; Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Koornstra JJ; Department of Gastroenterology & Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., Langers AM; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Lepistö A; Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland; Research Programs Unit, Genome-Scale Biology, University of Helsinki, Helsinki, Finland., Morak M; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany; Center of Medical Genetics, Munich, Germany., Möslein G; Center for Hereditary Tumors, HELIOS Klinikum Wuppertal, University Witten-Herdecke, Wuppertal, Germany., Peltomäki P; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland., Pylvänäinen K; Department of Education and Science, Central Finland Hospital District, Jyväskylä, Finland., Rahner N; Institute of Human Genetics, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Renkonen-Sinisalo L; Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland; Research Programs Unit, Genome-Scale Biology, University of Helsinki, Helsinki, Finland., Schulmann K; Department of Hematology and Oncology, Klinikum Hochsauerland, Meschede, Germany; MVZ Arnsberg, Medical Practice for Hematology and Oncology, Arnsberg, Germany., Steinke-Lange V; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany; Center of Medical Genetics, Munich, Germany., Stenzinger A; Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Strassburg CP; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., van de Meeberg PC; Department of Gastroenterology & Hepatology, Slingeland Hospital, Doetinchem, The Netherlands., van Kouwen M; Department of Gastroenterology & Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands., van Leerdam M; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Vangala DB; Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany., Vecht J; Department of Gastroenterology & Hepatology, Isala Zwolle, Zwolle, The Netherlands., Verhulst ML; Department of Gastroenterology & Hepatology, Maxima Medical Centre, Eindhoven, The Netherlands., von Knebel Doeberitz M; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Weitz J; Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus of the Technical University Dresden, Dresden, Germany., Zachariae S; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Mecklin JP; Department of Surgery, Central Finland Central Hospital, Jyväskylä, Finland; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Kloor M; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Vasen HF; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Gastroenterology [Gastroenterology] 2020 Apr; Vol. 158 (5), pp. 1326-1333. Date of Electronic Publication: 2020 Jan 08.

No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies.

Autor: Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. Electronic address: christoph.engel@imise.uni-leipzig.de., Vasen HF; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands., Seppälä T; Department of Abdominal Surgery, Helsinki University Hospital, Helsinki, Finland., Aretz S; Institute of Human Genetics, University of Bonn, Bonn, Germany; Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany., Bigirwamungu-Bargeman M; Department of Gastroenterology and Hepatology, Medisch Spectrum Hospital, Enschede, The Netherlands., de Boer SY; Department of Gastroenterology and Hepatology, Slingeland Hospital, Doetinchem, The Netherlands., Bucksch K; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Büttner R; Institute of Pathology, University of Cologne, Cologne, Germany., Holinski-Feder E; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany; Center of Medical Genetics, Munich, Germany., Holzapfel S; Institute of Human Genetics, University of Bonn, Bonn, Germany; Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany., Hüneburg R; Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Jacobs MAJM; Department of Gastroenterology and Hepatology, Free University Medical Centre, Amsterdam, The Netherlands., Järvinen H; Department of Abdominal Surgery, Helsinki University Hospital, Helsinki, Finland., Kloor M; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., von Knebel Doeberitz M; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Koornstra JJ; Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., van Kouwen M; Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands., Langers AM; Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands., van de Meeberg PC; Department of Gastroenterology and Hepatology, Slingeland Hospital, Doetinchem, The Netherlands., Morak M; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany; Center of Medical Genetics, Munich, Germany., Möslein G; Center for Hereditary Tumors, HELIOS Klinikum Wuppertal, University Witten-Herdecke, Wuppertal, Germany., Nagengast FM; Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands., Pylvänäinen K; Department of Education and Research, Jyväskylä Central Hospital, Jyväskylä, Finland., Rahner N; Institute of Human Genetics, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany., Renkonen-Sinisalo L; Department of Abdominal Surgery, Helsinki University Hospital, Helsinki, Finland., Sanduleanu S; Department of Gastroenterology and Hepatology, University Medical Centre Maastricht, Maastricht, The Netherlands., Schackert HK; Department of Surgical Research, Technische Universität Dresden, Dresden, Germany., Schmiegel W; Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany., Schulmann K; Department of Internal Medicine, Hematology and Oncology, Klinikum Arnsberg, Arnsberg, Germany., Steinke-Lange V; Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany; Center of Medical Genetics, Munich, Germany., Strassburg CP; Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Vecht J; Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands., Verhulst ML; Department of Gastroenterology and Hepatology, Maxima Medical Centre, Eindhoven, The Netherlands., de Vos Tot Nederveen Cappel W; Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands., Zachariae S; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Mecklin JP; Departments of Education and Research and Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland; Sports and Health Sciences, Jyväskylä University, Jyväskylä, Finland., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.

Publikováno v: Gastroenterology [Gastroenterology] 2018 Nov; Vol. 155 (5), pp. 1400-1409.e2. Date of Electronic Publication: 2018 Jul 29.

Extracolonic cancer risk in Dutch patients with APC (adenomatous polyposis coli)-associated polyposis.

Autor: Ghorbanoghli Z; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands., Bastiaansen BA; Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Langers AM; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Nagengast FM; Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Poley JW; Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Hardwick JC; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Koornstra JJ; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Sanduleanu S; Department of Internal Medicine, Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands., de Vos Tot Nederveen Cappel WH; Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands., Witteman BJ; Department of Gastroenterology, Gelderse Vallei Hospital, Ede, The Netherlands., Morreau H; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Dekker E; Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Vasen HF; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands.

Publikováno v: Journal of medical genetics [J Med Genet] 2018 Jan; Vol. 55 (1), pp. 11-14. Date of Electronic Publication: 2017 May 10.

Biobanking of fresh-frozen endoscopic biopsy specimens from esophageal adenocarcinoma.

Autor: Stiekema J; Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Cats A; Department of Gastroenterology and Hepatology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Boot H; Department of Gastroenterology and Hepatology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Langers AM; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Balague Ponz O; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., van Velthuysen ML; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Braaf LM; Core Facility Molecular Pathology and Biobanking, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Nieuwland M; Deep Sequencing Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands., van Sandick JW; Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Publikováno v: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2016 Nov; Vol. 29 (8), pp. 1100-1106. Date of Electronic Publication: 2015 Nov 06.

Equivalent Helicobacter pylori infection rates in Lynch syndrome mutation carriers with and without a first-degree relative with gastric cancer.

Autor: Soer EC; Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands. e.c.soer@amc.uva.nl., Leicher LW; Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands., Langers AM; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Isala Clinics, P.O. box 10400, 8000 GK, Zwolle, The Netherlands., van de Meeberg PC; Department of Gastroenterology and Hepatology, Slingeland Ziekenhuis, Doetinchem, The Netherlands., van der Wouden EJ; Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands., Koornstra JJ; Department of Gastroenterology and Hepatology, Groningen University Medical Center, Groningen, The Netherlands., Bigirwamungu-Bargeman M; Department of Gastroenterology and Hepatology, Medisch Spectrum Twente, Enschede, The Netherlands., Vasen HF; The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands., de Vos tot Nederveen Cappel WH; Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands.

Publikováno v: International journal of colorectal disease [Int J Colorectal Dis] 2016 Mar; Vol. 31 (3), pp. 693-7. Date of Electronic Publication: 2016 Feb 04.