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The proteasome regulates body weight and systemic nutrient metabolism during fasting.

Autor: Langer, Henning Tim, Taylor, Samuel R., Ahmed, Mujmmail, Perrier, Tiffany, Ahmed, Tanvir, Goncalves, Marcus D.

Publikováno v: American Journal of Physiology: Endocrinology & Metabolism; Nov2023, Vol. 325 Issue 5, pE500-E512, 13p

Systemic Ketone Replacement Does Not Improve Survival or Cancer Cachexia in Mice With Lung Cancer

Autor: Langer, Henning Tim, Ramsamooj, Shakti, Liang, Roger J., Grover, Rahul, Hwang, Seo-Kyoung, Goncalves, Marcus DaSilva

Publikováno v: Frontiers in Oncology. 12

Cachexia is a debilitating comorbidity affecting many lung cancer patients. We have previously found that cachectic mice with lung cancer have reduced serum ketone body levels due to low PPARα activity in the liver. Restoring hepatic PPARα activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1456eb8396c668ea6903520e8840c861
https://doi.org/10.3389/fonc.2022.903157

Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer.

Autor: Langer HT; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Ramsamooj S; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Dantas E; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Murthy A; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Ahmed M; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Hwang SK; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Grover R; Weill Cornell Medical College, New York, NY, USA., Pozovskiy R; Hunter College, City University of New York, New York, NY, 10065, USA., Liang RJ; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Queiroz AL; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Brown JC; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA., White EP; Department of Genetics, Rutgers Cancer Institute of New Jersey, The State University of New Jersey, New Brunswick, NJ 08901, USA., Janowitz T; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Goncalves AMD; Division of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Meyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 02. Date of Electronic Publication: 2023 Aug 02.