Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy.

Autor: Wienke J; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address: j.wienke-4@prinsesmaximacentrum.nl., Visser LL; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Kholosy WM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Keller KM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Barisa M; Cancer Section, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK., Poon E; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Munnings-Tomes S; Cancer Section, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK., Himsworth C; Cancer Section, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK., Calton E; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Rodriguez A; Hoffman-La Roche, Basel, Switzerland., Bernardi R; Genentech, A Member of the Roche Group, South San Francisco, CA, USA., van den Ham F; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., van Hooff SR; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Matser YAH; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Tas ML; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Lijnzaad P; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Borst AL; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Zappa E; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Bergsma FJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Strijker JGM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Verhoeven BM; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Mei S; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA., Kramdi A; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France., Restuadi R; Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; NIHR Biomedical Research Centre, Great Ormond Street Hospital, London, UK., Sanchez-Bernabeu A; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; Netherlands Proteomics Centre, Utrecht University, Utrecht, the Netherlands., Cornel AM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Holstege FCP; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Gray JC; Centre for Cancer Immunology, University of Southampton, Southampton, UK., Tytgat GAM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Scheijde-Vermeulen MA; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Wijnen MHWA; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Dierselhuis MP; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Straathof K; University College London (UCL) Great Ormond Street Institute of Child Health, London, UK; UCL Cancer Institute, London, UK., Behjati S; Wellcome Sanger Institute, Hinxton, UK; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Paediatrics, University of Cambridge, Cambridge, UK., Wu W; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; Netherlands Proteomics Centre, Utrecht University, Utrecht, the Netherlands; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Department of Pharmacy, National University of Singapore, Singapore, Singapore., Heck AJR; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands; Netherlands Proteomics Centre, Utrecht University, Utrecht, the Netherlands., Koster J; Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands., Nierkens S; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Janoueix-Lerosey I; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France., de Krijger RR; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Baryawno N; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Chesler L; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Anderson J; Cancer Section, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, England, UK., Caron HN; Hoffman-La Roche, Basel, Switzerland., Margaritis T; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., van Noesel MM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Division Imaging & Cancer, University Medical Center Utrecht, Utrecht, the Netherlands., Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Department of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

Publikováno v: Cancer cell [Cancer Cell] 2024 Feb 12; Vol. 42 (2), pp. 283-300.e8. Date of Electronic Publication: 2024 Jan 04.

Myeloproliferative Neoplasm Driven by ETV6-ABL1 in an Adolescent with Recent History of Burkitt Leukemia.

Autor: Renzi S; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON M4B 1B3, Canada.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, CHUL-Laval, Laval University, Quebec City, QC G1V 4G2, Canada., Algawahmed F; Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2M9, Canada., Davidson S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Langenberg KPS; Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands., Fuligni F; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Ali S; Department of Pediatric Haematology and Bone Marrow Transplant, Leeds Teaching Hospitals, Leeds LS9 7TF, UK., Anderson N; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Brunga L; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Bartram J; Department of Hematology, Great Ormond Street Hospital, London WC1N 3JH, UK., Abdelhaleem M; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Naqvi A; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON M4B 1B3, Canada.; Department of Paediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada., Beimnet K; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Schuh A; Department of Haematology, Princess Margaret Hospital, Toronto, ON M5G 2C1, Canada., Tierens A; Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2M9, Canada., Malkin D; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON M4B 1B3, Canada.; Department of Paediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada., Shlien A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Shago M; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Villani A; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON M4B 1B3, Canada.; Department of Paediatrics, University of Toronto, Toronto, ON M5S 1A1, Canada.

Publikováno v: Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Jun 21; Vol. 30 (7), pp. 5946-5952. Date of Electronic Publication: 2023 Jun 21.

The potential of PARP as a therapeutic target across pediatric solid malignancies.

Autor: Keller KM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Koetsier J; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Schild L; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Amo-Addae V; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Eising S; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., van den Handel K; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Ober K; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Koopmans B; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Essing A; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., van den Boogaard ML; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Jäger N; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Kool M; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Pfister S; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany., Dolman MEM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Children's Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, NSW, Australia.; School of Women's and Children's Health, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. j.j.molenaar@prinsesmaximacentrum.nl.; Department of Pharmaceutical Sciences, University Utrecht, Utrecht, the Netherlands. j.j.molenaar@prinsesmaximacentrum.nl., van Hooff SR; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.

Publikováno v: BMC cancer [BMC Cancer] 2023 Apr 05; Vol. 23 (1), pp. 310. Date of Electronic Publication: 2023 Apr 05.

Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program 'iTHER'.

Autor: Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands. Electronic address: k.p.s.langenberg@prinsesmaximacentrum.nl., Meister MT; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Bakhuizen JJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Boer JM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van Eijkelenburg NKA; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Hulleman E; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Ilan U; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Looze EJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Dierselhuis MP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van der Lugt J; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Breunis W; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Universitäts-Kinderspital Zürich, Steinwiesstrasse 75, 8032 Zürich, Switzerland., Schild LG; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Ober K; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van Hooff SR; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Scheijde-Vermeulen MA; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Hiemcke-Jiwa LS; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Flucke UE; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Kranendonk MEG; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Wesseling P; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Sonneveld E; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Punt S; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Boltjes A; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van Dijk F; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Verwiel ETP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Volckmann R; Department of Oncogenomics, Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands., Hehir-Kwa JY; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Kester LA; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Koudijs MMJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Waanders E; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Holstege FCP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Vormoor HJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Universitäts-Kinderspital Zürich, Steinwiesstrasse 75, 8032 Zürich, Switzerland; Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Hoving EW; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van Noesel MM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Division Imaging & Cancer, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Pieters R; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Kool M; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Stumpf M; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Balasubramanian GP; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Van Tilburg CM; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Jones BC; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Jongmans MCJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Kuiper RP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., de Krijger RR; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Wijnen MHW; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., den Boer ML; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Zwaan CM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Kemmeren P; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Koster J; Department of Oncogenomics, Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands., Tops BBJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Goemans BF; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands.

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2022 Nov; Vol. 175, pp. 311-325. Date of Electronic Publication: 2022 Sep 29.

The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets.

Autor: van Tilburg CM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. cornelis.vantilburg@kitz-heidelberg.de.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany., Pfaff E; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Pajtler KW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Fiesel P; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Jones BC; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Balasubramanian GP; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Stark S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Johann PD; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Swabian Children's Cancer Center, Paediatric and Adolescent Medicine, University Medical Center Augsburg, Augsburg, Germany., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schramm K; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Dikow N; Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany., Hirsch S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany., Sutter C; Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany., Grund K; Institute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany., von Stackelberg A; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Oncology and Hematology Department, Charité-Campus Virchow Klinikum, Berlin, Germany., Kulozik AE; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ), Heidelberg, Germany., Lissat A; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Oncology and Hematology Department, Charité-Campus Virchow Klinikum, Berlin, Germany., Borkhardt A; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Oncology and Hematology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Meisel R; German Cancer Consortium (DKTK), Heidelberg, Germany.; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Reinhardt D; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; West German Cancer Center, Pediatrics III, University Hospital Essen, Essen, Germany., Klusmann JH; Department of Pediatric Hematology, Oncology and Hemostaseology, Clinic for Pediatrics, University Hospital of Frankfurt, Goethe-University Frankfurt, Frankfurt/Main, Germany., Fleischhack G; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; West German Cancer Center, Pediatrics III, University Hospital Essen, Essen, Germany., Tippelt S; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; West German Cancer Center, Pediatrics III, University Hospital Essen, Essen, Germany., von Schweinitz D; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Schmid I; Department of Pediatric Oncology and Hematology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Kramm CM; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., von Bueren AO; Department of Pediatrics, Obstetrics and Gynecology, Division of Pediatric Hematology and Oncology, University Hospital Geneva, Geneva, Switzerland., Calaminus G; Department of Pediatric Oncology and Hematology, University Hospital Bonn, Bonn, Germany., Vorwerk P; Department of Pediatric Oncology and Hematology, University Hospital Magdeburg, Magdeburg, Germany., Graf N; Department of Pediatric Oncology and Hematology, University Hospital Saarland, Saarland, Germany., Westermann F; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Fischer M; National Center for Tumor Diseases (NCT) Network, Germany.; Department of Experimental Pediatric Oncology, University Hospital Köln, and Center for Molecular Medicine (CMMC), Medical Faculty, Cologne, Germany., Eggert A; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Oncology and Hematology Department, Charité-Campus Virchow Klinikum, Berlin, Germany., Burkhardt B; Clinic of Pediatric Oncology and Hematology, University Hospital Münster, Muenster, Germany., Wößmann W; Department of Pediatric Oncology and Hematology, University Hospital Hamburg, Hamburg, Germany., Nathrath M; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, Klinikum Kassel, Kassel, Germany.; Department of Pediatrics, Technical University Munich, Munich, Germany., Hecker-Nolting S; National Center for Tumor Diseases (NCT) Network, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany., Frühwald MC; National Center for Tumor Diseases (NCT) Network, Germany.; Swabian Children's Cancer Center, Paediatric and Adolescent Medicine, University Medical Center Augsburg, Augsburg, Germany., Schneider DT; Clinic of Pediatrics, Municipal Hospital Dortmund, Dortmund, Germany., Brecht IB; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Department of Pediatric Oncology and Hematology, University Hospital Tübingen, Tübingen, Germany., Ketteler P; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; West German Cancer Center, Pediatrics III, University Hospital Essen, Essen, Germany., Fulda S; German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute for Experimental Cancer Research in Pediatrics, Goethe University Frankfurt, Frankfurt, Germany., Koscielniak E; National Center for Tumor Diseases (NCT) Network, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany., Meister MT; German Cancer Consortium (DKTK), Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Scheer M; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Oncology and Hematology Department, Charité-Campus Virchow Klinikum, Berlin, Germany., Hettmer S; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schwab M; German Cancer Consortium (DKTK), Heidelberg, Germany.; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology, Pharmacy and Biochemistry, and Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany., Tremmel R; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany., Øra I; Department of Pediatric Oncology and Hematology, Skane University Hospital Lund, and HOPE-ITCC Unit, Pediatric Oncology, Karolinska University Hospital, Stockholm, Sweden., Hutter C; St. Anna Children's Hospital, Department of Pediatrics, Medical University of Vienna, and St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria., Gerber NU; Department of Oncology, University Children's Hospital, Zurich, Switzerland., Lohi O; Tampere Center for Child Health Research and Tays Cancer Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Kazanowska B; Department of Pediatric Hematology/Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland., Kattamis A; Division of Pediatric Hematology-Oncology, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece., Filippidou M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Pediatric Hematology-Oncology, First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece., Goemans B; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Zwaan CM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Milde T; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany., Jäger N; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Wolf S; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany., Reuss D; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Sahm F; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., von Deimling A; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Dirksen U; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; West German Cancer Center, Pediatrics III, University Hospital Essen, Essen, Germany., Freitag A; NCT Trial Center, National Center for Tumor Diseases, Heidelberg, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Witt R; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany., Lichter P; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kopp-Schneider A; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Department Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Utrecht University, Department of Pharmaceutical Sciences, Utrecht, the Netherlands., Capper D; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT) Network, Germany.

Publikováno v: Cancer discovery [Cancer Discov] 2021 Nov; Vol. 11 (11), pp. 2764-2779. Date of Electronic Publication: 2021 Aug 09.