Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters.

Autor: Nouailles G; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Adler JM; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Institut für Virologie, Freie Universität Berlin, Berlin, Germany., Pennitz P; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Peidli S; Institute of Pathology Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Institute for Biology, IRI Life Sciences, Humboldt-Universität zu Berlin, Berlin, Germany., Teixeira Alves LG; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Baumgardt M; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Bushe J; Institut für Tierpathologie, Freie Universität Berlin, Berlin, Germany., Voss A; Institut für Tierpathologie, Freie Universität Berlin, Berlin, Germany., Langenhagen A; Institut für Tierpathologie, Freie Universität Berlin, Berlin, Germany., Langner C; Institut für Virologie, Freie Universität Berlin, Berlin, Germany., Martin Vidal R; Institut für Virologie, Freie Universität Berlin, Berlin, Germany., Pott F; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany., Kazmierski J; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany., Ebenig A; Product Testing of IVMPs, Division of Veterinary Medicines, Paul-Ehrlich-Institut, Langen, Germany., Lange MV; Product Testing of IVMPs, Division of Veterinary Medicines, Paul-Ehrlich-Institut, Langen, Germany., Mühlebach MD; Product Testing of IVMPs, Division of Veterinary Medicines, Paul-Ehrlich-Institut, Langen, Germany.; German Center for Infection Research (DZIF), partner site Gießen-Marburg-Langen, Giessen, Germany., Goekeri C; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Faculty of Medicine, Cyprus International University, Nicosia, Cyprus., Simmons S; Institute of Physiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Xing N; Institut für Virologie, Freie Universität Berlin, Berlin, Germany., Abdelgawad A; Institut für Virologie, Freie Universität Berlin, Berlin, Germany., Herwig S; Department of Gynecology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Cichon G; Department of Gynecology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Niemeyer D; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Infection Research (DZIF), partner site Charité, Berlin, Germany., Drosten C; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Infection Research (DZIF), partner site Charité, Berlin, Germany., Goffinet C; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany., Landthaler M; Berlin Institute for Medical Systems Biology (BIMSB) Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), and Institute for Biology, Humboldt-Universität zu Berlin, Berlin, Germany., Blüthgen N; Institute of Pathology Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Institute for Biology, IRI Life Sciences, Humboldt-Universität zu Berlin, Berlin, Germany., Wu H; School of Life Sciences, Chongqing University, Chongqing, China., Witzenrath M; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Gruber AD; Institut für Tierpathologie, Freie Universität Berlin, Berlin, Germany., Praktiknjo SD; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany., Osterrieder N; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong, China., Wyler E; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Kunec D; Institut für Virologie, Freie Universität Berlin, Berlin, Germany., Trimpert J; Institut für Virologie, Freie Universität Berlin, Berlin, Germany. trimpert.jakob@fu-berlin.de.

Publikováno v: Nature microbiology [Nat Microbiol] 2023 May; Vol. 8 (5), pp. 860-874. Date of Electronic Publication: 2023 Apr 03.

Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds.

Autor: Schmitz KS; Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands., Lange MV; Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands., Gommers L; Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands., Handrejk K; Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands., Porter DP; Gilead Sciences, Foster City, CA 94404, USA., Alabi CA; Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA., Moscona A; Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.; Center for Host-Pathogen Interaction, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Porotto M; Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.; Center for Host-Pathogen Interaction, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', 81100 Caserta, Italy., de Vries RD; Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands., de Swart RL; Department of Viroscience, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

Publikováno v: Viruses [Viruses] 2022 May 29; Vol. 14 (6). Date of Electronic Publication: 2022 May 29.