Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood–brain barrier

Autor: de Boer Ag, de Lange Ec, Douwe D. Breimer, Meindert Danhof

Publikováno v: Brain Research Reviews. 25:27-49

For the study of the pharmacokinetics of drugs in the brain a number of in vivo techniques is available, including autoradiography, imaging techniques, cerebrospinal fluid sampling and in vivo voltammetry, which all have their specific advantages and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8e427ed9aab9d1e69640071eedb85b
https://doi.org/10.1016/s0165-0173(97)00014-3

Exploring K p,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport.

Autor: Zhang M; Division of Systems Pharmacology and Pharmacy, Predictive Pharmacology Group, Leiden Academic Centre of Drug Research, Leiden University, Gorlaeus Laboratories, Leiden, the Netherlands., Vuist IM; Charles River Laboratories, Groningen, the Netherlands., Rottschäfer V; Mathematical Institute, Leiden University, Leiden, the Netherlands; Korteweg-de Vries Institute for Mathematics, University of Amsterdam, P.O. Box 94248, 1090 GE Amsterdam, the Netherlands., de Lange EC; Division of Systems Pharmacology and Pharmacy, Predictive Pharmacology Group, Leiden Academic Centre of Drug Research, Leiden University, Gorlaeus Laboratories, Leiden, the Netherlands. Electronic address: ecmdelange@lacdr.leidenuniv.nl.

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Dec 01; Vol. 203, pp. 106883. Date of Electronic Publication: 2024 Aug 22.

Ornithine aspartate effects on bacterial composition and metabolic pathways in a rat model of steatotic liver disease.

Autor: Lange EC; Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-007, Brazil.; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-007, Brazil., Rampelotto PH; Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-007, Brazil.; Bioinformatics and Biostatistics Core Facility, Universidade Federal do Rio Grande do Sul, Porto Alegre 91501-970, Brazil.; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-007, Brazil., Longo L; Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-007, Brazil.; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-007, Brazil., de Freitas LBR; Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-007, Brazil., Uribe-Cruz C; Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-007, Brazil.; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-007, Brazil.; Facultad de Ciencias de la Salud, Universidad Católica de las Misiones, Posadas, Misiones 3300, Argentina., Alvares-da-Silva MR; Experimental Laboratory of Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-007, Brazil.; Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-007, Brazil.; Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Porto Alegre 90035-007, RS, Brazil.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) researcher, Brasília 71605-001, Brazil. mrsilva@hcpa.edu.br.

Publikováno v: World journal of hepatology [World J Hepatol] 2024 May 27; Vol. 16 (5), pp. 832-842.

Environmental, sex-specific and genetic determinants of infant social behaviour in a wild primate.

Autor: Lange EC; Department of Biology, Duke University, Durham, NC, USA.; Department of Biological Sciences, SUNY Oswego, Oswego, NY, USA., Griffin M; Department of Biology, Duke University, Durham, NC, USA., Fogel AS; University Program in Genetics and Genomics, Duke University, Durham, NC, USA.; Department of Evolutionary Anthropology, Duke University, Durham, NC, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA., Archie EA; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Tung J; Department of Biology, Duke University, Durham, NC, USA.; Department of Evolutionary Anthropology, Duke University, Durham, NC, USA.; Population Research Institute, Duke University, Durham, NC, USA.; Department of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Alberts SC; Department of Biology, Duke University, Durham, NC, USA.; Department of Evolutionary Anthropology, Duke University, Durham, NC, USA.; Population Research Institute, Duke University, Durham, NC, USA.

Publikováno v: Proceedings. Biological sciences [Proc Biol Sci] 2023 Nov 29; Vol. 290 (2011), pp. 20231597. Date of Electronic Publication: 2023 Nov 15.

A Causal Mediation Model for Longitudinal Mediators and Survival Outcomes with an Application to Animal Behavior.

Autor: Zeng S; Facebook, Inc., Seattle, WA, USA., Lange EC; Department of Biology, Duke University, Durham, NC, USA., Archie EA; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA., Campos FA; Department of Antropology, University of Texas at San Antonio, San Antonio, TX, USA., Alberts SC; Department of Biology, Duke University, Durham, NC, USA.; Department of Evolutionary Anthropology, Duke University, Durham, NC, USA., Li F; Department of Statistical Science, Duke University, 214 Old Chemistry Building, Durham, NC 27708, USA.

Publikováno v: Journal of agricultural, biological, and environmental statistics [J Agric Biol Environ Stat] 2023 Jun; Vol. 28 (2), pp. 197-218. Date of Electronic Publication: 2022 Apr 05.