Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Langan, RA"'
Autor:
Boyken, SE, Chen, Z, Groves, B, Langan, RA, Oberdorfer, G, Ford, A, Gilmore, JM, Xu, C, DiMaio, F, Pereira, JH, Sankaran, B, Seelig, G, Zwart, PH, Baker, D
Publikováno v:
Science (New York, N.Y.), vol 352, iss 6286
Boyken, SE; Chen, Z; Groves, B; Langan, RA; Oberdorfer, G; Ford, A; et al.(2016). De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352(6286), 680-687. doi: 10.1126/science.aad8865. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/12p9z45p
Boyken, SE; Chen, Z; Groves, B; Langan, RA; Oberdorfer, G; Ford, A; et al.(2016). De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity. Science, 352(6286), 680-687. doi: 10.1126/science.aad8865. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/12p9z45p
In nature, structural specificity in DNA and proteins is encoded differently: In DNA, specificity arises from modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises largely from buried hydrophobic packing comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cfe655bab750994dbdc70825a193d2b3
https://escholarship.org/uc/item/12p9z45p
https://escholarship.org/uc/item/12p9z45p
Autor:
Vulovic I; Institute for Protein Design, University of Washington, Seattle, WA 98195.; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195., Yao Q; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125., Park YJ; Department of Biochemistry, University of Washington, Seattle, WA 98195., Courbet A; Institute for Protein Design, University of Washington, Seattle, WA 98195.; Department of Biochemistry, University of Washington, Seattle, WA 98195., Norris A; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.; Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210., Busch F; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.; Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210., Sahasrabuddhe A; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.; Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210., Merten H; Department of Biochemistry, University of Zurich, 8057 Zurich, Switzerland., Sahtoe DD; Institute for Protein Design, University of Washington, Seattle, WA 98195.; Department of Biochemistry, University of Washington, Seattle, WA 98195., Ueda G; Institute for Protein Design, University of Washington, Seattle, WA 98195.; Department of Biochemistry, University of Washington, Seattle, WA 98195., Fallas JA; Institute for Protein Design, University of Washington, Seattle, WA 98195.; Department of Biochemistry, University of Washington, Seattle, WA 98195., Weaver SJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125., Hsia Y; Institute for Protein Design, University of Washington, Seattle, WA 98195.; Department of Biochemistry, University of Washington, Seattle, WA 98195., Langan RA; Institute for Protein Design, University of Washington, Seattle, WA 98195.; Department of Biochemistry, University of Washington, Seattle, WA 98195., Plückthun A; Department of Biochemistry, University of Zurich, 8057 Zurich, Switzerland., Wysocki VH; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.; Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH 43210., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195., Jensen GJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.; HHMI, California Institute of Technology, Pasadena, CA 91125.; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602., Baker D; Institute for Protein Design, University of Washington, Seattle, WA 98195; dabaker@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195.; HHMI, University of Washington, Seattle, WA 98195.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jun 08; Vol. 118 (23).
Autor:
Quijano-Rubio A; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Yeh HW; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Park J; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Sana Biotechnology, Inc, Seattle, WA, USA., Lee H; Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Langan RA; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Outpace Bio, Inc., Seattle, WA, USA., Boyken SE; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Outpace Bio, Inc., Seattle, WA, USA., Lajoie MJ; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.; Outpace Bio, Inc., Seattle, WA, USA., Cao L; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Chow CM; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Miranda MC; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Wi J; Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea., Hong HJ; Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea., Stewart L; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA., Oh BH; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA. bhoh@kaist.ac.kr.; Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, South Korea. bhoh@kaist.ac.kr., Baker D; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
Publikováno v:
Nature [Nature] 2021 Mar; Vol. 591 (7850), pp. 482-487. Date of Electronic Publication: 2021 Jan 27.
Autor:
Lajoie MJ; Institute for Protein Design, University of Washington, Seattle, WA, USA. mlajoie@lyell.com dabaker@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Boyken SE; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Salter AI; Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Bruffey J; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA, USA., Rajan A; Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Langan RA; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Olshefsky A; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Muhunthan V; Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Bick MJ; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Gewe M; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Quijano-Rubio A; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Johnson J; Institute for Protein Design, University of Washington, Seattle, WA, USA., Lenz G; Institute for Protein Design, University of Washington, Seattle, WA, USA., Nguyen A; Institute for Protein Design, University of Washington, Seattle, WA, USA., Pun S; Department of Bioengineering, University of Washington, Seattle, WA, USA.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA., Correnti CE; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Riddell SR; Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA., Baker D; Institute for Protein Design, University of Washington, Seattle, WA, USA. mlajoie@lyell.com dabaker@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
Publikováno v:
Science (New York, N.Y.) [Science] 2020 Sep 25; Vol. 369 (6511), pp. 1637-1643. Date of Electronic Publication: 2020 Aug 20.
Publikováno v:
ACS synthetic biology [ACS Synth Biol] 2020 Sep 18; Vol. 9 (9), pp. 2316-2323. Date of Electronic Publication: 2020 Aug 20.
Autor:
Ng AH; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; The UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley, Berkeley, CA, USA.; Cell Design Initiative, University of California, San Francisco, CA, USA., Nguyen TH; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Gómez-Schiavon M; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Dods G; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Langan RA; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA., Boyken SE; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Samson JA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Waldburger LM; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Dueber JE; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., El-Samad H; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. hana.el-samad@ucsf.edu.; Cell Design Initiative, University of California, San Francisco, CA, USA. hana.el-samad@ucsf.edu.; Chan-Zuckerberg Biohub, San Francisco, CA, USA. hana.el-samad@ucsf.edu.
Publikováno v:
Nature [Nature] 2020 Mar; Vol. 579 (7798), pp. E8.
Autor:
Fajgenbaum DC; Department of Medicine and., Langan RA; Department of Medicine and., Japp AS; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Partridge HL; Department of Medicine and., Pierson SK; Department of Medicine and., Singh A; Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada., Arenas DJ; Department of Medicine and., Ruth JR; Castleman Disease Collaborative Network, Philadelphia, Pennsylvania, USA., Nabel CS; Dana Farber Cancer Research Institute, Boston, Massachusetts, USA., Stone K; Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Okumura M; Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Schwarer A; Department of Haematology and Oncology, Eastern Health Monash University Clinical School, Melbourne, Victoria, Australia., Jose FF; Department of Rheumatology and., Hamerschlak N; Department of Hematology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Wertheim GB; Department of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Jordan MB; Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Cohen AD; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Krymskaya V; Department of Medicine and., Rubenstein A; Department of Medicine and., Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Kambayashi T; Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., van Rhee F; Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Uldrick TS; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Publikováno v:
The Journal of clinical investigation [J Clin Invest] 2019 Aug 13; Vol. 129 (10), pp. 4451-4463. Date of Electronic Publication: 2019 Aug 13.
Autor:
Ng AH; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; The UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley, Berkeley, CA, USA.; Cell Design Initiative, University of California, San Francisco, CA, USA., Nguyen TH; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Gómez-Schiavon M; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Dods G; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Langan RA; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA., Boyken SE; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Samson JA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Waldburger LM; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Dueber JE; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., El-Samad H; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. hana.el-samad@ucsf.edu.; Cell Design Initiative, University of California, San Francisco, CA, USA. hana.el-samad@ucsf.edu.; Chan-Zuckerberg Biohub, San Francisco, CA, USA. hana.el-samad@ucsf.edu.
Publikováno v:
Nature [Nature] 2019 Aug; Vol. 572 (7768), pp. 265-269. Date of Electronic Publication: 2019 Jul 24.
Autor:
Langan RA; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA., Boyken SE; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Ng AH; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; The UC Berkeley-UCSF Graduate Program in Bioengineering, UCSF, San Francisco, CA, USA.; The UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley, Berkeley, CA, USA., Samson JA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Dods G; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Westbrook AM; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Nguyen TH; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Lajoie MJ; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Chen Z; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA., Berger S; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Mulligan VK; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Dueber JE; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Novak WRP; Department of Chemistry, Wabash College, Crawfordsville, IN, USA., El-Samad H; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.; Chan-Zuckerberg Biohub, San Francisco, CA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
Publikováno v:
Nature [Nature] 2019 Aug; Vol. 572 (7768), pp. 205-210. Date of Electronic Publication: 2019 Jul 24.