Synthesis and Biological Evaluation of Ligustrazine Derivatives

Autor: Wenhao Wu, Chao Zhang, Xintong Liang, Wei-xiong Liu, Lang-di Chen

Publikováno v: Chemistry of Natural Compounds. 53:114-117

Synthesized ligustrazine derivatives (1a, 1b, 1c (novel)) were structurally confirmed by mass spectrometry, 1H NMR, and 13C NMR. The cytotoxic activities of all derivatives were evaluated by MTS assay in three human prostate cancer cell lines (PC-3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f77fb9245b7903110cc179b3196182f
https://doi.org/10.1007/s10600-017-1922-6

Synthesis and Evaluation of Novel Ligustrazine Derivatives as Multi-Targeted Inhibitors for the Treatment of Alzheimer’s Disease

Autor: Lihong Yu, Wei-xiong Liu, Wei Yi, Hong Ji, Xuehua Zheng, Wenhao Wu, Lang-di Chen, Peiquan Zhang, Chao Zhang, Guolin Luo, Guoquan Xie, Xintong Liang

Publikováno v: Molecules
Volume 23
Issue 10
Molecules, Vol 23, Iss 10, p 2540 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

A series of novel ligustrazine derivatives 8a&ndash
r were designed, synthesized, and evaluated as multi-targeted inhibitors for anti-Alzheimer&rsquo
s disease (AD) drug discovery. The results showed that most of them exhibited a potent abi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7d7a8e7a56351ec0d727604150895a