Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Lang PA"'
Publikováno v:
Proceedings of the National Academy of Sciences. 119
β-Lactams are the most important class of antibacterials, but their use is increasingly compromised by resistance, most importantly via serine β-lactamase (SBL)-catalyzed hydrolysis. The scope of β-lactam antibacterial activity can be substantiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bcdc0b6ea6a681d6878fc60a92113b
https://doi.org/10.1073/pnas.2117310119
https://doi.org/10.1073/pnas.2117310119
Autor:
Lang Pan, Ke Wang, Wenjing Hao, Yaoyao Xue, Xu Zheng, Ritwika S Basu, Tapas K Hazra, Azharul Islam, Yashoda Hosakote, Bing Tian, Matthieu G Gagnon, Xueqing Ba, Istvan Boldogh
Publikováno v:
PLoS Pathogens, Vol 20, Iss 10, p e1012616 (2024)
Respiratory syncytial virus (RSV), along with other prominent respiratory RNA viruses such as influenza and SARS-CoV-2, significantly contributes to the global incidence of respiratory tract infections. These pathogens induce the production of reacti
Externí odkaz:
https://doaj.org/article/4fb7b110766a4feca2c22f32b1f19250
Publikováno v:
Journal of Integrative Bioinformatics, Vol 21, Iss 1, Pp 524-31 (2024)
Julia is a general purpose programming language that was designed for simplifying and accelerating numerical analysis and computational science. In particular the Scientific Machine Learning (SciML) ecosystem of Julia packages includes frameworks for
Externí odkaz:
https://doaj.org/article/6ae0cf3ace624c3f97687bbf28d30f80
Autor:
Zhijia Sun, Yu Ma, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Hao Zhang, Xiaoming Yang, Maxim Barnard, Robert Clarke, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv, Rory Collins, Richard Peto, Robin Walters, Daniel Avery, Derrick Bennett, Lazaros Belbasis, Ruth Boxall, Ka Hung Chan, Charlotte Clarke, Johnathan Clarke, Ahmed Edris Mohamed, Hannah Fry, Simon Gilbert, Pek Kei Im, Andri Iona, Maria Kakkoura, Christiana Kartsonaki, Hubert Lam, Kuang Lin, James Liu, Mohsen Mazidi, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryanm Rahmati, Paul Ryder, Saredo Said, Dan Schmidt, Becky Stevens, Iain Turnbull, Baihan Wang, Lin Wang, Neil Wright, Pang Yao, Xiao Han, Can Hou, Qingmei Xia, Chao Liu, Lang Pan, Zengchang Pang, Ruqin Gao, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Yajing Zang, Liang Cheng, Xiaocao Tian, Hua Zhang, Yaoming Zhai, Feng Ning, Xiaohui Sun, Feifei Li, Silu Lv, Junzheng Wang, Wei Hou, Wei Sun, Shichun Yan, Xiaoming Cui, Chi Wang, Zhenyuan Wu, Yanjie Li, Quan Kang, Huiming Luo, Tingting Ou, Xiangyang Zheng, Zhendong Guo, Shukuan Wu, Yilei Li, Huimei Li, Ming Wu, Yonglin Zhou, Jinyi Zhou, Ran Tao, Jie Yang, Jian Su. Fang Liu, Jun Zhang, Yihe Hu, Yan Lu, Liangcai Ma, Aiyu Tang, Shuo Zhang, Jianrong Jin, Jingchao Liu, Mei Lin, Zhenzhen Lu, Lifang Zhou, Changping Xie, Jian Lan, Tingping Zhu, Yun Liu, Liuping Wei, Liyuan Zhou, Ningyu Chen, Yulu Qin, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Mingqiang Yuan, Xia Wu, Wei Jiang, Jiaqiu Liu, Qiang Sun, Faqing Chen, Xiaolan Ren, Caixia Dong, Hui Zhang, Enke Mao, Xiaoping Wang, Tao Wang, Xi Zhang, Kai Kang, Shixian Feng, Huizi Tian, Lei Fan, XiaoLin Li, Huarong Sun, Pan He, Xukui Zhang, Min Yu, Ruying Hu, Hao Wang, Xiaoyi Zhang, Yuan Cao, Kaixu Xie, Lingli Chen, Dun Shen, Xiaojun Li, Donghui Jin, Li Yin, Huilin Liu, Zhongxi Fu, Xin Xu, Jianwei Chen, Yuan Peng, Libo Zhang, Chan Qu
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 49, Iss , Pp 101140- (2024)
Summary: Background: In non-high-risk individuals, risk-category-based atherosclerotic cardiovascular disease (ASCVD) screening strategies may be more cost-effective than one-size-fits-all approaches. However, current decisions are constrained by a l
Externí odkaz:
https://doaj.org/article/ac21ba1981a846cbae73f09ff16a2ae4
Autor:
Nisha Tapryal, Anirban Chakraborty, Kaushik Saha, Azharul Islam, Lang Pan, Koa Hosoki, Ibrahim M. Sayed, Jason M. Duran, Joshua Alcantara, Vanessa Castillo, Courtney Tindle, Altaf H. Sarker, Maki Wakamiya, Victor J. Cardenas, Gulshan Sharma, Laura E. Crotty Alexander, Sanjiv Sur, Debashis Sahoo, Gourisankar Ghosh, Soumita Das, Pradipta Ghosh, Istvan Boldogh, Tapas K. Hazra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract SARS-CoV-2 infection-induced aggravation of host innate immune response not only causes tissue damage and multiorgan failure in COVID-19 patients but also induces host genome damage and activates DNA damage response pathways. To test whether
Externí odkaz:
https://doaj.org/article/a49dab695e8a47c59e6fe11737dc9248
Autor:
Yuanyuan Chen, Shing Chan, Derrick Bennett, Xiaofang Chen, Xianping Wu, Yalei Ke, Jun Lv, Dianjianyi Sun, Lang Pan, Pei Pei, Ling Yang, Yiping Chen, Junshi Chen, Zhengming Chen, Liming Li, Huaidong Du, Canqing Yu, Aiden Doherty, on behalf of the China Kadoorie Biobank Collaborative Group
Publikováno v:
International Journal of Behavioral Nutrition and Physical Activity, Vol 20, Iss 1, Pp 1-11 (2023)
Abstract Background Movement behaviours, including physical activity, sedentary behaviour, and sleep have been shown to be associated with several chronic diseases. However, they have not been objectively measured in large-scale prospective cohort st
Externí odkaz:
https://doaj.org/article/7165d344ff334c52b22daa4533f1ff81
Autor:
Krajnc, A, Brem, J, Hinchliffe, P, Calvopiña, K, Panduwawala, TD, Lang, PA, Kamps, JJAG, Tyrrell, JM, Widlake, E, Saward, BG, Walsh, TR, Spencer, J, Schofield, CJ
Publikováno v:
Journal of Medicinal Chemistry
Krajnc, A, Brem, J, Hinchliffe, P, Calvopina, K A, Panduwawala, T D, Lang, P, Kamps, J J A G, Tyrrell, J M, Widlake, E, Saward, B G, Walsh, T R, Spencer, J & Schofield, C J 2019, ' Bicyclic Boronate VNRX-5133 Inhibits Metallo-and Serine-β-Lactamases ', Journal of Medicinal Chemistry, vol. 62, no. 18, pp. 8544-8556 . https://doi.org/10.1021/acs.jmedchem.9b00911
Krajnc, A, Brem, J, Hinchliffe, P, Calvopina, K A, Panduwawala, T D, Lang, P, Kamps, J J A G, Tyrrell, J M, Widlake, E, Saward, B G, Walsh, T R, Spencer, J & Schofield, C J 2019, ' Bicyclic Boronate VNRX-5133 Inhibits Metallo-and Serine-β-Lactamases ', Journal of Medicinal Chemistry, vol. 62, no. 18, pp. 8544-8556 . https://doi.org/10.1021/acs.jmedchem.9b00911
The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and some clinically important metallo-β-lactamases (MBLs), including NDM-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::389e3f8a9e9d77616787dcd444f15990
https://doi.org/10.1021/acs.jmedchem.9b00911
https://doi.org/10.1021/acs.jmedchem.9b00911
The L,D-transpeptidases (Ldts) are promising antibiotic targets for treating tuberculosis. We report screening of cysteine-reactive inhibitors against LdtMt2 from Mycobacterium tuberculosis. Structural studies on LdtMt2 with potent inhibitor ebselen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::62efc0035ba581ba891c5417852c7ed0
https://doi.org/10.1039/c9cc04145a
https://doi.org/10.1039/c9cc04145a
Autor:
Yuanyuan Chen, Shing Chan, Derrick Bennett, Xiaofang Chen, Xianping Wu, Yalei Ke, Jun Lv, Dianjianyi Sun, Lang Pan, Pei Pei, Ling Yang, Yiping Chen, Junshi Chen, Zhengming Chen, Liming Li, Huaidong Du, Canqing Yu, Aiden Doherty, the China Kadoorie Biobank Collaborative Group
Publikováno v:
International Journal of Behavioral Nutrition and Physical Activity, Vol 21, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/12341d506ebf44878fb513dceb4fe3a5
Autor:
Leicheng Liu, Lamei Wu, Zongfang Li, Yuhang Fang, Boming Ju, Sisi Zhang, Lianyang Bai, Lang Pan
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
IntroductionBromus japonicus is one of the most notorious agricultural weeds in China. The long-term use of ALS-inhibiting herbicides has led to rapid evolution of herbicide resistance in B. japonicus. B. japonicus population (BJ-R) surviving mesosul
Externí odkaz:
https://doaj.org/article/e1843b415fe54ec790aec2262e25f5dc