Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lanfranco R.P. Troncone"'
Phoneutria nigriventer spider toxin Tx2-6 induces priapism in mice even after cavernosal denervation
Autor:
Lanfranco R.P. Troncone, Fábio Carlos Magnoli, Katherine Garcia Ravelli, Luana Baracho Gonçalves, Adriana T. Ramos
Publikováno v:
Toxicon. 130:29-34
The Phoneutria nigriventer spider toxin Tx2-6 causes priapism in humans and mice. This toxin produces a delay in Sodium channel inactivation, generalized vascular congestion and death by respiratory failure. NO-Synthase inhibitors seem to abolish tox
Autor:
João Paulo S. Fernandes, Ana Claudia Torrecilhas, Aleksandro Martins Balbino, Lanfranco R.P. Troncone, Marina T. Varela, Michelle Fidelis Corrêa, Richardt G. Landgraf
Publikováno v:
Chemical Biology & Drug Design. 90:317-322
The histamine receptors (HRs) are members of G-protein-coupled receptor superfamily and traditional targets of huge therapeutic interests. Recently, H3 R and H4 R have been explored as targets for drug discovery, including in the search for dual-acti
Publikováno v:
Neuropsychobiology. 73:184-190
Vasopressin and CRH have complementary roles in the secretion of ACTH following different stress modalities. The concomitant use of V1b and CRF1 receptor antagonists completely inhibits ACTH secretion in response to different stress modalities. The c
Autor:
Adriana T. Ramos, Fábio Carlos Magnoli, Miguel Srougi, Katia R. M. Leite, Lanfranco R.P. Troncone, Enrico Andrade
Publikováno v:
Toxicon. 60:797-801
Phoneutria nigriventer spider bite causes priapism, an effect attributed to the peptide toxins Tx2-5 and Tx2-6 and involving nitric oxide. Tx2-6 (MW = 5287) is known to delay the inactivation of Sodium channels in the same fashion as many other venom
Publikováno v:
Brain Research. 1168:32-37
Glycine is known as an inhibitory neurotransmitter in the spinal cord and forebrain but its precise role in the forebrain is largely overlooked. This investigation evaluated whether glycine alters acetylcholine, glutamate or dopamine release from str
Autor:
Carina Talarico Rizzi, Antônio Carlos Cassola, Enzo Wanke, Emanuele Schiavon, João L. Carvalho-de-Souza, Lanfranco R.P. Troncone
Publikováno v:
Toxicon. 50:553-562
Crotamine is a peptide toxin from the venom of the rattlesnake Crotalus durissus terrificus that induces a typical hind-limb paralysis of unknown nature. Hind limbs have a predominance of fast-twitching muscles that bear a higher density of sodium ch
Autor:
Edson T. Yamashiro, Solange M.T. Serrano, Tarcísio Liberato, Lanfranco R.P. Troncone, André Zelanis
Publikováno v:
Amino acids. 48(3)
Here we present a proteomic characterization of Phoneutria nigriventer venom. A shotgun proteomic approach allowed the identification, for the first time, of O-glycosyl hydrolases (chitinases) in P. nigriventer venom. The electrophoretic profiles und
Publikováno v:
Neuroendocrinology. 84:309-316
Background/Aims: Corticotrophin-releasing hormone (CRH), adrenocorticotrophic hormone (ACTH) and corticosterone are secreted during stress. These mediators may be involved in anxiety, depression and post-traumatic stress disorder, therefore antagonis
Autor:
Shao-Ying Hua, Lanfranco R.P. Troncone, Donald B. Elrick, Milton P. Charlton, Ivo Lebrun, Fábio Carlos Magnoli, John Georgiou
Publikováno v:
Journal of Neurophysiology. 90:3529-3537
Peptide channel blockers found in venoms of many predators are useful pharmacological tools and potential therapeutic agents. The venom of the Brazilian spider Phoneutria nigriventer contains a fraction, ω-phonetoxin-IIA (ω-Ptx-IIA, 8360 MW), which
Publikováno v:
Zoo Biology. 20:399-406
Habituation to captivity is difficult for some species. Understanding the motivational elements involved in predation may ease this habituation. Seventy-one Brazilian jararaca snakes (Bothrops jararaca [Wied, 1824], Viperidae, Crotalinae) recently ca