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pro vyhledávání: '"Lane J. Shirley"'
Publikováno v:
Reproduction. 133:855-863
Primordial follicles are long-lived structures assembled early in life. The mechanisms that control the balance between the conservation and the activation of primordial follicles are critically important for fertility and dictate the onset of menopa
Autor:
John O. Schorge, Sushma Gurumurthy, Shana N. Wingo, Kwok-Kin Wong, Russell Broaddus, J. Marshall Haynie, Lane J. Shirley, Cristina Contreras, Nabeel Bardeesy, Esra A. Akbay, Diego H. Castrillon
Publikováno v:
Cancer research. 68(3)
Mutations in the LKB1 tumor suppressor gene result in the Peutz-Jeghers syndrome, an autosomal dominant condition characterized by hamartomatous polyps of the gastrointestinal tract and a dramatically increased risk of epithelial malignancies at othe
Autor:
Esra A. Akbay, Cristina Contreras, Teresa D. Gallardo, Lane J. Shirley, Meredith J. Shidler, George B. John, J. Marshall Haynie, Samuel E. Ward, Diego H. Castrillon
Publikováno v:
Genetics. 177(1)
Female infertility syndromes are among the most prevalent chronic health disorders in women, but their genetic basis remains unknown because of uncertainty regarding the number and identity of ovarian factors controlling the assembly, preservation, a
Publikováno v:
Genesis (New York, N.Y. : 2000). 45(6)
Cell type-specific genetic modification using the Cre/loxP system is a powerful tool for genetic analysis of distinct cell lineages. Because of the exquisite specificity of Vasa expression (confined to the germ cell lineage in invertebrate and verteb
Publikováno v:
Biology of Reproduction. 83:49-49
Publikováno v:
Developmental Biology. (1):197-204
In mammals, oocytes are packaged into compact structures–primordial follicles–which remain inert for prolonged intervals until individual follicles resume growth via a process known as primordial follicle activation. Here we show that the phospho