Výsledky vyhledávání - "Landoni, Federica"

Effect of TNF-alpha and IL-17 on TLR expression and Langerhans cells phenotype in a three-dimensional model of normal human skin: a morphological study

Autor: Donetti, Elena, Arnaboldi, Francesca, Cornaghi, Laura Brigida, Landoni, Federica, Baruffaldi Preis, Franz, Prignano, Francesca

Toll-like receptors (TLRs) are essential for innate immunity and contribute to create the skin barrier. Their abnormal stimulation is involved in the development of several dermatological diseases, among which psoriasis. Tumor Necrosis Factor (TNF)-a

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Langerhans cells and Toll Like Receptors: how do they act and react in an in vitro psoriatic microenvironment?

Autor: Donetti, Elena, Arnaboldi, Francesca, Cornaghi, Laura Brigida, Landoni, Federica, Baruffaldi Preis, Franz, Prignano, Francesca

Tumor Necrosis Factor (TNF)-α, interleukin (IL)-17, IL-22 and IL-23 are involved in the psoriasis pathogenesis and represent a strong proinflammatory stimulus. Both epidermal keratinocytes (KCs) and Langerhans cells (LCs) early respond promoting an

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Modulation of epidermal proliferation and terminal differentiation in a promising ex vivo human skin model mimicking a psoriatic microenvironment

Autor: Donetti, Elena, Mastroianni, Nicolino, Cornaghi, Laura, Arnaboldi, Francesca, Landoni, Federica, Prignano, Francesca

Epidermal keratinocyte hyperproliferation is one of the key features involved in the formation/progression of psoriatic lesions and is driven by cytokines, among which TNF-α, IL-17, IL-22 and IL-23, secreted by both activated resident immune cells a

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Interleukin 17 affects early and late biomarkers of terminal differentiation in a three-dimensional model of normal human skin

Autor: Mastroianni, Nicolino, Cornaghi, Laura, Arnaboldi, Francesca, Landoni, Federica, Prignano, Francesca, Donetti, Elena

Interleukin (IL)-17 expression has been correlated with the pathogenesis of mul- tiple autoimmune diseases, as rheumatoid arthritis, multiple sclerosis, and, more recently, psoriasis (1). During plaque formation, the interplay between immunocytes and

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Effects of UV rays and natural compound repairs using an ex-vivo human skin model: morphological and genotoxicological analysis

Autor: Cornaghi, Brigida, Landoni, Federica, Baruffaldi Preis, Franz William, Calò, Rossella, Marabini, Laura

Among the key factors in skin disorders such as wrinkling, dryness and photo-aging, the exposure to solar ultraviolet (UV) radiation plays a central role (1). Recently, compounds rich in polyphenols such as Thymus Vulgaris Leaf (TVL) extract and its

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Evaluation of protective effect of Thymol on UVBinduced damage in an ex-vivo human skin tissue model: morphological analysis and genotoxic evaluations

Autor: Cornaghi, Laura, Donetti, Elena, Landoni, Federica, Marabini, Laura, Baruffaldi Preis, Franz W., Calò, Rossella

insult, among which is the most important solar ultraviolet (UV) radiation (Bernerd et al., 2001). For this reason, the use of human skin tissue obtained from plastic aesthetic surgery represents a simple but efficient experimental approach to reprod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26846e064e087f7079af111d32591667

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Morphological analysis of the effects of tumor necrosis factor-alpha and interleukin-17 in a three-dimensional organotipic model of normal human skin

Autor: Cornaghi, Laura, Landoni, Federica, Baruffaldi Preis, Franz W., Tripo, Lara, Pescitelli, Leonardo, Romagnoli, Paolo, Prignano, Francesca, Donetti, Elena

Psoriasis is an autoimmune chronic inflammatory disease in which epidermal keratinocytes and innate immunity effector cells play a pivotal role in the lesion formation in genetically predisposed subjects (Bonifati et al., 1999). Among the several cyt

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Effect of a psoriatic microenvironment in a threedimensional model of normal human skin

Autor: Donetti, Elena, Cornaghi, Laura, Sallese, Giulia, Landoni, Federica, Gramatica, Furio, Bedoni, Marzia, Pescitelli, Leonardo, Prignano, Francesca

Among the cytokines involved in the pathogenesis and in the progression of the disease, tumor necrosis factor (TNF)-alpha and interleukin (IL)-17 are the most relevant. A three dimensional model of organotypic human skin cultures is a valuable approa

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