Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Landon J, Hansen"'
1
Akademický článek
MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization
Autor: Landon J. Hansen, Rui Yang, Kristen Roso, Wenzhe Wang, Lee Chen, Qing Yang, Christopher J. Pirozzi, Yiping He
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Glioblastoma (GBM) is a lethal brain cancer known for its potent immunosuppressive effects. Loss of Methylthioadenosine Phosphorylase (MTAP) expression, via gene deletion or epigenetic silencing, is one of the most common alterations in GBM.
Externí odkaz: https://doaj.org/article/8dcb9631ee3e49108c2a38b9357b329e
Zobrazit plný text záznamu
2
Akademický článek
The integrated genomic and epigenomic landscape of brainstem glioma
Autor: Lee H. Chen, Changcun Pan, Bill H. Diplas, Cheng Xu, Landon J. Hansen, Yuliang Wu, Xin Chen, Yibo Geng, Tao Sun, Yu Sun, Peng Zhang, Zhen Wu, Junting Zhang, Deling Li, Yang Zhang, Wenhao Wu, Yu Wang, Guangyu Li, Jie Yang, Xiaoyue Wang, Ce Xu, Sizhen Wang, Matthew S. Waitkus, Yiping He, Roger E. McLendon, David M. Ashley, Hai Yan, Liwei Zhang
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical
Externí odkaz: https://doaj.org/article/20c3ed793a784a5b8bd512a9238d11e8
Zobrazit plný text záznamu
3
Akademický článek
Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells
Autor: Simranjit X. Singh, Rui Yang, Kristen Roso, Landon J. Hansen, Changzheng Du, Lee H. Chen, Paula K. Greer, Christopher J. Pirozzi, Yiping He
Publikováno v: Biomedicines, Vol 10, Iss 4, p 751 (2022)
Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, pro
Externí odkaz: https://doaj.org/article/a2f34eeb4d164ba6a4ede50903e97f18
Zobrazit plný text záznamu
4
Reexamining the Role of Postoperative ICU Admission for Patients Undergoing Elective Craniotomy: A Systematic Review*
Autor: Tej D, Azad, Pavan P, Shah, Nivedha V, Kannapadi, Jordina, Rincon-Torroella, Yuanxuan, Xia, Lydia J, Bernhardt, Landon J, Hansen, Joshua, Materi, Divyaansh, Raj, Christopher M, Jackson, Debraj, Mukherjee, Gary L, Gallia, Jon, Weingart, Jose I, Suarez, Henry, Brem, Chetan, Bettegowda
Publikováno v: Critical Care Medicine. 50:1380-1393
The standard-of-care for postoperative care following elective craniotomy has historically been ICU admission. However, recent literature interrogating complications and interventions during this postoperative ICU stay suggests that all patients may
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f861f36cf0c4e16743bbd4d6bb2e70ac
https://doi.org/10.1097/ccm.0000000000005588
Zobrazit plný text záznamu
5
Akademický článek
A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis
Autor: Changzheng Du, Landon J. Hansen, Simranjit X. Singh, Feiyifan Wang, Ran Sun, Casey J. Moure, Kristen Roso, Paula K. Greer, Hai Yan, Yiping He
Publikováno v: Cell Reports, Vol 28, Iss 12, Pp 3199-3211.e5 (2019)
Summary: H2AX safeguards genomic stability in a dose-dependent manner; however, mechanisms governing its proteostasis are poorly understood. Here, we identify a PRMT5-RNF168-SMURF2 cascade that regulates H2AX proteostasis. We show that PRMT5 sustains
Externí odkaz: https://doaj.org/article/459387299e6e4c179961106be258eabb
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje