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Autor:
Carol A. Mulrooney, Morgan Welzel-O’Shea, Bérénice C. Lemercier, Edward B. Holson, Landon Durak, Sarathy Kesavan, Jeremy R. Duvall, Jingqiang Wei, Florence F. Wagner, Adrien Joliton, Laura M. Panko, Maurice D. Lee, Lisa A. Marcaurelle, Lakshmi B. Akella, Haibo Liu, Emeline L. Davoine, Jason T. Lowe, Méryl Thomas, Etienne J. Donckele, Michael Foley, Byung-Chul Suh, Giovanni Muncipinto, Ann Rowley, Jean-Charles Marie, Baudouin Gerard
Publikováno v:
The Journal of Organic Chemistry. 77:7187-7211
The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of represen