Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Landon, Pastushok"'
Autor:
Landon Pastushok, Shrutii Sarda, Karen Mochoruk, Wayne Hill, Loni T. Pickle, Michelle Toro, Carolina Gonzalez, Stephanie Ostresh, Timothy J. Looney, Chenchen Yang, Julie Stakiw, Mark J. Bosch, Hadi Goubran, C. Ronald Geyer, Geoffrey M. Lowman, John F. DeCoteau
Publikováno v:
Journal of Molecular Pathology, Vol 5, Iss 1, Pp 45-65 (2024)
B-cell neoplasms possess clonal B-cell receptor rearrangements (BCR clonotype lineages) that can be identified by sequencing the B-cell repertoire for use in diagnostics, risk stratification, and high-sensitivity monitoring. BCR somatic hypermutation
Externí odkaz:
https://doaj.org/article/da7a5fbbb6434fb9a56fc2e46e4e3bc9
Autor:
Hannah E. Salapa, Patricia A. Thibault, Cole D. Libner, Yulian Ding, Joseph-Patrick W. E. Clarke, Connor Denomy, Catherine Hutchinson, Hashim M. Abidullah, S. Austin Hammond, Landon Pastushok, Frederick S. Vizeacoumar, Michael C. Levin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Neurodegeneration is the primary driver of disease progression in multiple sclerosis (MS) resulting in permanent disability, creating an urgent need to discover its underlying mechanisms. Herein, we establish that dysfunction of the RNA bind
Externí odkaz:
https://doaj.org/article/3e648027a8214c6e949a7e6dd685c808
Publikováno v:
Therapeutic Antibodies ISBN: 9781071614495
Phage display is commonly used to select target-binding antibody fragments from large libraries containing billions of unique antibody clones. In practice, selection outputs are often highly heterogenous, making it desirable to recover sequence infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e731200b4c62de0bb3a1d7889a2b91c
https://doi.org/10.1007/978-1-0716-1450-1_6
https://doi.org/10.1007/978-1-0716-1450-1_6
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2313
Phage display is commonly used to select target-binding antibody fragments from large libraries containing billions of unique antibody clones. In practice, selection outputs are often highly heterogenous, making it desirable to recover sequence infor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0761fc7b5548d591fbe3278688b28d33
https://pubmed.ncbi.nlm.nih.gov/34478134
https://pubmed.ncbi.nlm.nih.gov/34478134
Autor:
Geoffrey Marc Lowman, Landon Pastushok, Karen Mochoruk, Wayne Hill, Michelle Toro, Loni Pickle, Carolina Gonzalez, Stephanie Ostresh, Shrutii Sarda, Chenchen Yang, Julie Stakiw, Mark Bosch, Hadi Goubran, Ron Geyer, John DeCoteau
Publikováno v:
Cancer Research. 82:2293-2293
Introduction: B cell repertoire analysis by next-generation sequencing (NGS) is at the forefront of leukemia and lymphoma research. Some advantages provided by NGS-based techniques include a lower limit-of-detection and simpler paths to standardizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::146d7364280d983c52ee121eb8c3b74c
https://doi.org/10.1158/1538-7445.am2022-2293
https://doi.org/10.1158/1538-7445.am2022-2293
Autor:
Wendy Bernhard, Ayman El-Sayed, C. Ronald Geyer, Landon Pastushok, Humphrey Fonge, Carolina Gonzalez, Wayne Hill, Kris Barreto
Publikováno v:
Theranostics
In vivo imaging is influenced by the half-life, tissue penetration, biodistribution, and affinity of the imaging probe. Immunoglobulin G (IgG) is composed of discrete domains with known functions, providing a template for engineering antibody fragmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55261978b8f97761e064ee1441b730e6
https://doi.org/10.7150/thno.24252
https://doi.org/10.7150/thno.24252
Autor:
Ronald Geyer, Shrutii Sarda, Wayne Hill, Stephanie Ostresh, Julie Stakiw, Carolina Gonzalez, Mark Bosch, Geoffrey Lowman, John F. DeCoteau, Landon Pastushok, Loni Pickle, Hadi Goubran, Michelle Toro, Karen Mochoruk, Chenchen Yang
Publikováno v:
Blood. 138:1881-1881
Introduction B cell repertoire analysis by next-generation sequencing (NGS) is at the forefront of leukemia and lymphoma research. Some advantages provided by NGS-based techniques include a lower limit-of-detection and simpler paths to standardizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfb70552f553e17d8997c31b1dbc3df7
https://doi.org/10.1182/blood-2021-152987
https://doi.org/10.1182/blood-2021-152987
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
DNA damaging chemotherapies are successful in cancer therapy, however, the damage can be reversed by DNA repair mechanisms that may be up-regulated in cancer cells. We hypothesized that inhibiting RAD51, a protein involved in homologous recombination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ec4b703d87ce0e55a7d314adc02e42
https://doi.org/10.1038/s41598-019-47600-y
https://doi.org/10.1038/s41598-019-47600-y
Autor:
J. N. Mark Glover, Barry Ziola, Trevor F. Moraes, Michael J. Ellison, Landon Pastushok, Lindsay Pelzer, Wei Xiao
Publikováno v:
Biochemical and Biophysical Research Communications. 378:563-568
Ubiquitin conjugating enzyme variants (Uev) Uev1 and Mms2 share >90% sequence identity but with distinct biological functions. Here, we report the monomeric and heterodimeric crystal structures of Uev1 and comparison with that of Mms2. Uev1 alone or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957110ea3854972bca8ae2c0f5428269
https://doi.org/10.1016/j.bbrc.2008.11.089
https://doi.org/10.1016/j.bbrc.2008.11.089
Autor:
Barry Ziola, Sean A. McKenna, Trevor F. Moraes, Vishva M. Dixit, Honglin Zhou, Michael J. Ellison, Wei Xiao, Parker L. Andersen, Landon Pastushok
Publikováno v:
The Journal of Cell Biology
Ubc13, a ubiquitin-conjugating enzyme (Ubc), requires the presence of a Ubc variant (Uev) for polyubiquitination. Uevs, although resembling Ubc in sequence and structure, lack the active site cysteine residue and are catalytically inactive. The yeast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99209a5a2ffd6b60a0f6e138b81c835
https://doi.org/10.1083/jcb.200502113
https://doi.org/10.1083/jcb.200502113