Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lancelote Leong"'
Autor:
Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen Lopez, César P. Márquez, Carissa Chu, Patricia S. Li, Erica Oropeza, Imelda Tenggara, Janet Cowan, Jeffry P. Simko, June M. Chan, Terence Friedlander, Alexander W. Wyatt, Rahul Aggarwal, Pamela L. Paris, Peter R. Carroll, Felix Feng, John S. Witte
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Prostate cancer is the most commonly diagnosed neoplasm in American men. Although existing biomarkers may detect localized prostate cancer, additional strategies are necessary for improving detection and identifying aggressive disease that m
Externí odkaz:
https://doaj.org/article/3bda01622d5a48dca54ff3356e239cb8
Autor:
Rebecca E. Graff, Taylor B. Cavazos, Khanh K. Thai, Linda Kachuri, Sara R. Rashkin, Joshua D. Hoffman, Stacey E. Alexeeff, Maruta Blatchins, Travis J. Meyers, Lancelote Leong, Caroline G. Tai, Nima C. Emami, Douglas A. Corley, Lawrence H. Kushi, Elad Ziv, Stephen K. Van Den Eeden, Eric Jorgenson, Thomas J. Hoffmann, Laurel A. Habel, John S. Witte, Lori C. Sakoda
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
While genetic loci shared between cancer types have been identified, cross-cancer relationships for polygenic risk scores have not been well studied. Here, the authors have developed polygenic risk scores for 16 cancers in two large cohorts and ident
Externí odkaz:
https://doaj.org/article/c8c7f06feddc43b4892e0628726c8ee8
Autor:
Clinton L. Cario, Emmalyn Chen, Lancelote Leong, Nima C. Emami, Karen Lopez, Imelda Tenggara, Jeffry P. Simko, Terence W. Friedlander, Patricia S. Li, Pamela L. Paris, Peter R. Carroll, John S. Witte
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Cell-free DNA’s (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel desig
Externí odkaz:
https://doaj.org/article/4b8f1ffaa66a497293d31c9ad249bfe8
Autor:
Joshua D Hoffman, Rebecca E Graff, Nima C Emami, Caroline G Tai, Michael N Passarelli, Donglei Hu, Scott Huntsman, Dexter Hadley, Lancelote Leong, Arunabha Majumdar, Noah Zaitlen, Elad Ziv, John S Witte
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006690 (2017)
Breast cancer is the most common solid organ malignancy and the most frequent cause of cancer death among women worldwide. Previous research has yielded insights into its genetic etiology, but there remains a gap in the understanding of genetic facto
Externí odkaz:
https://doaj.org/article/b0037e7ea70547d18e0d3e822bc242c0
Autor:
Terence W. Friedlander, Pamela L. Paris, Patricia Li, Karen Lopez, Rahul Aggarwal, Clinton L. Cario, Alexander W. Wyatt, Imelda Tenggara, Felix Y. Feng, Emmalyn Chen, Cesar P Marquez, Erica Oropeza, Jeffry P. Simko, Lancelote Leong, Carissa Chu, June M. Chan, Peter R. Carroll, John S. Witte, Janet E. Cowan
Publikováno v:
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Prostate cancer is the most commonly diagnosed neoplasm in American men. Although existing biomarkers may detect localized prostate cancer, additional strategies are necessary for improving detection and identifying aggressive disease that may requir
Autor:
Maruta A. Blatchins, Stephen K. Van Den Eeden, Caroline G. Tai, Lawrence H. Kushi, John S. Witte, Lancelote Leong, Taylor B. Cavazos, Travis J. Meyers, Rebecca E. Graff, Douglas A. Corley, Stacey E. Alexeeff, Linda Kachuri, Khanh K. Thai, Thomas J. Hoffmann, Eric Jorgenson, Joshua D. Hoffman, Elad Ziv, Lori C. Sakoda, Sara R. Rashkin, Laurel A. Habel, Nima C. Emami
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15285feb7cdbfef25a8a53413e0b989
https://escholarship.org/uc/item/2x39f6df
https://escholarship.org/uc/item/2x39f6df
Autor:
Felix Y. Feng, Peter R. Carroll, John S. Witte, Lancelote Leong, Terence W. Friedlander, Imelda Tenggara, Jeffry P. Simko, Daniel K. Wells, Erica Oropeza, Rahul Aggarwal, Emmalyn Chen, June M. Chan, Clinton L. Cario, Robin Kageyama, Janet E. Cowan, Cesar P Marquez, Karen Lopez, Pamela L. Paris, Patricia Li
Publikováno v:
JCO precision oncology, vol 5, iss 5
JCO Precis Oncol
JCO Precis Oncol
PURPOSE Cell-free DNA (cfDNA) may allow for minimally invasive identification of biologically relevant genomic alterations and genetically distinct tumor subclones. Although existing biomarkers may detect localized prostate cancer, additional strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920052ef65ba87427dfe5fc855a3e8d5
https://escholarship.org/uc/item/07m4h3sd
https://escholarship.org/uc/item/07m4h3sd
Autor:
Karen Lopez, Terence W. Friedlander, Pamela L. Paris, Lancelote Leong, Patricia Li, Imelda Tenggara, John S. Witte, Nima C. Emami, Emmalyn Chen, Clinton L. Cario, Jeffry P. Simko, Peter R. Carroll
Publikováno v:
BMC cancer, vol 20, iss 1
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
BMC Cancer
BackgroundCell-free DNA’s (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc638658527357621eacec5ed9be69a
https://escholarship.org/uc/item/7pr3j4sj
https://escholarship.org/uc/item/7pr3j4sj
Cell-free DNA as a biomarker for prostate cancer: elevated concentration and decreased fragment size
Autor:
June M. L. Chan, John S. Witte, Pamela L. Paris, Patricia Li, Cesar P Marquez, Lancelote Leong, Terence W. Friedlander, Peter R. Carroll, Janet E. Cowan, Rahul Aggarwal, Carissa Chu, Erica Oropeza, Imelda Tenggara, Karen Lopez, Clinton L. Cario, Alexander W. Wyatt, Emmalyn Chen, Felix Feng, Jeffry P. Simko
PurposeProstate cancer is the most commonly diagnosed neoplasm in American men. Although existing biomarkers may detect localized prostate cancer, additional strategies are necessary for improving detection and identifying aggressive disease that may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edae3ca5bafa2cfe5c61022a507380c6
https://doi.org/10.1101/2020.07.26.215020
https://doi.org/10.1101/2020.07.26.215020
Autor:
Maruta A. Blatchins, Rebecca E. Graff, Douglas A. Corley, Stacey E. Alexeeff, Joshua D. Hoffman, Taylor B. Cavazos, Elad Ziv, Lancelote Leong, Lawrence H. Kushi, John S. Witte, Travis J. Meyers, Khanh K. Thai, Lori C. Sakoda, Linda Kachuri, Caroline G. Tai, Thomas J. Hoffmann, Laurel A. Habel, Nima C. Emami, Eric Jorgenson, Sara R. Rashkin, Stephen K. Van Den Eeden
Genetic factors that influence etiologic mechanisms shared across cancers could affect the risk of multiple cancer types. We investigated polygenic risk score (PRS)-specific pleiotropy across 17 cancers in two large population-based cohorts. The stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3730ec6ea40a71982cb8605641be00
https://doi.org/10.1101/2020.01.18.911578
https://doi.org/10.1101/2020.01.18.911578