Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Lance Wells"'
Autor:
David Chmielewski, Eric A. Wilson, Grigore Pintilie, Peng Zhao, Muyuan Chen, Michael F. Schmid, Graham Simmons, Lance Wells, Jing Jin, Abhishek Singharoy, Wah Chiu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding, and membrane fusion during virus entry and constitute the primary target for vaccine and drug development. How the structure dynamics of the full-lengt
Externí odkaz:
https://doaj.org/article/59f6e796a34541e8ac45dd396b94428c
Autor:
M. Osman Sheikh, Chantelle J. Capicciotti, Lin Liu, Jeremy Praissman, Dahai Ding, Daniel G. Mead, Melinda A. Brindley, Tobias Willer, Kevin P. Campbell, Kelley W. Moremen, Lance Wells, Geert-Jan Boons
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Matriglycan, a repeating disaccharide on α-dystroglycan, is the receptor for Lassa virus and specific extracellular matrix proteins. Here, the authors demonstrate that matriglycan, in a length-dependent tunable manner, is both necessary and sufficie
Externí odkaz:
https://doaj.org/article/6f16e38680614cf4be0f9a79a71c7b0f
Autor:
Justin D. Shepard, Brendan T. Freitas, Sergio E. Rodriguez, Florine E. M. Scholte, Kailee Baker, Madelyn R. Hutchison, Jaron E. Longo, Holden C. Miller, Brady M. O’Boyle, Aarushi Tandon, Peng Zhao, Neil J. Grimsey, Lance Wells, Éric Bergeron, Scott D. Pegan
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Post-translational modification of host and viral proteins by ubiquitin and ubiquitin-like proteins plays a key role in a host’s ability to mount an effective immune response. Avian species lack a ubiquitin-like protein found in mammals and other n
Externí odkaz:
https://doaj.org/article/cdb1c66c866249dda32409df4b3c5592
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100214- (2020)
Summary: This protocol describes an integrated approach for analyzing site-specific N- and O-linked glycosylation of SARS-CoV-2 spike protein by mass spectrometry. Glycoproteomics analyzes intact glycopeptides to examine site-specific microheterogene
Externí odkaz:
https://doaj.org/article/8854b3eb16aa40908459ecc60209551f
Autor:
Rudo Kieft, Yang Zhang, Alexandre P Marand, Jose Dagoberto Moran, Robert Bridger, Lance Wells, Robert J Schmitz, Robert Sabatini
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008390 (2020)
Base J, β-D-glucosyl-hydroxymethyluracil, is a modification of thymine DNA base involved in RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa. Little is understood regarding how specific thymine residues are targeted for J-
Externí odkaz:
https://doaj.org/article/38f4685d7d8849febf24f65cfe34bdb6
Autor:
Tongqing Zhou, Nicole A. Doria-Rose, Cheng Cheng, Guillaume B.E. Stewart-Jones, Gwo-Yu Chuang, Michael Chambers, Aliaksandr Druz, Hui Geng, Krisha McKee, Young Do Kwon, Sijy O’Dell, Mallika Sastry, Stephen D. Schmidt, Kai Xu, Lei Chen, Rita E. Chen, Mark K. Louder, Marie Pancera, Timothy G. Wanninger, Baoshan Zhang, Anqi Zheng, S. Katie Farney, Kathryn E. Foulds, Ivelin S. Georgiev, M. Gordon Joyce, Thomas Lemmin, Sandeep Narpala, Reda Rawi, Cinque Soto, John-Paul Todd, Chen-Hsiang Shen, Yaroslav Tsybovsky, Yongping Yang, Peng Zhao, Barton F. Haynes, Leonidas Stamatatos, Michael Tiemeyer, Lance Wells, Diana G. Scorpio, Lawrence Shapiro, Adrian B. McDermott, John R. Mascola, Peter D. Kwong
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 719-732 (2017)
While the HIV-1-glycan shield is known to shelter Env from the humoral immune response, its quantitative impact on antibody elicitation has been unclear. Here, we use targeted deglycosylation to measure the impact of the glycan shield on elicitation
Externí odkaz:
https://doaj.org/article/aabe08812b3841a8a0593b8fc0b38355
Autor:
M. Osman Sheikh, Fariba Tayyari, Sicong Zhang, Michael T. Judge, D. Brent Weatherly, Francesca V. Ponce, Lance Wells, Arthur S. Edison
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
This study examined the relationship between glycans, metabolites, and development in C. elegans. Samples of N2 animals were synchronized and grown to five different time points ranging from L1 to a mixed population of adults, gravid adults, and offs
Externí odkaz:
https://doaj.org/article/cfab07cfa7fd4bc68297f7859ad28c39
Autor:
Elsenoor Klaver, Peng Zhao, Melanie May, Heather Flanagan-Steet, Hudson H. Freeze, Reid Gilmore, Lance Wells, Joseph Contessa, Richard Steet
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 6 (2019)
Global inhibition of N-linked glycosylation broadly reduces glycan occupancy on glycoproteins, but identifying how this inhibition functionally impacts specific glycoproteins is challenging. This limits our understanding of pathogenesis in the congen
Externí odkaz:
https://doaj.org/article/71db76a11e90405f8d9d510bf04c122f
Autor:
Yun Dong, Sonbol Shahid-Salles, Dan Sherling, Nathan Fechheimer, Nathan Iyer, Lance Wells, Marcus Fechheimer, Ruth Furukawa
Publikováno v:
Biology Open, Vol 5, Iss 6, Pp 807-818 (2016)
Hirano bodies are eosinophilic, actin-rich inclusions found in autopsied brains in numerous neurodegenerative diseases. The mechanism of Hirano body formation is unknown. Mass spectrometry analysis was performed to identify proteins from partially pu
Externí odkaz:
https://doaj.org/article/882dfcef50e4489ca331378b3d1ef8d1
Autor:
Wen-Han Yu, Peng Zhao, Monia Draghi, Claudia Arevalo, Christina B Karsten, Todd J Suscovich, Bronwyn Gunn, Hendrik Streeck, Abraham L Brass, Michael Tiemeyer, Michael Seaman, John R Mascola, Lance Wells, Douglas A Lauffenburger, Galit Alter
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 4, p e1006093 (2018)
Mounting evidence suggests that glycans, rather than merely serving as a "shield", contribute critically to antigenicity of the HIV envelope (Env) glycoprotein, representing critical antigenic determinants for many broadly neutralizing antibodies (bN
Externí odkaz:
https://doaj.org/article/95340b869fa04d0d8f0a1c79a288c7d5