Zobrazeno 1 - 10
of 583
pro vyhledávání: '"Lance R, McMahon"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new therapies. New migraine therapeutics are needed to address the current deficiencies that exist in the efficacy and adherence rate o
Externí odkaz:
https://doaj.org/article/b546ac27c15946b2960427b79b569952
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0309398 (2024)
For many cancer patients tumor burden negatively impacts quality of life due to associated pain onset. Neuropathic pain is commonly associated with late cancer stages, and is resultant of tumor metastasis to bone, herein referred to as cancer-induced
Externí odkaz:
https://doaj.org/article/65fad567637c4389aee424899fe9a082
Autor:
Kevin Luque-Sanchez, Jasmine Felix, Joshua Bilbrey, Luis Restrepo, Morgan Reeves, Lance R. McMahon, Jenny L. Wilkerson
Publikováno v:
Advances in Drug and Alcohol Research, Vol 3 (2023)
Nicotine is the primary psychoactive component responsible for maintaining tobacco dependence in humans. Chronic pain is often a consequence of tobacco-related pathologies, and the development of a dual therapeutic that could treat chronic pain and t
Externí odkaz:
https://doaj.org/article/0e05576652064312b1cedf7713cc1043
Autor:
Jack E. Henningfield, Marek C. Chawarski, Albert Garcia-Romeu, Oliver Grundmann, Norsyifa Harun, Zurina Hassan, Christopher R. McCurdy, Lance R. McMahon, Abhisheak Sharma, Mohammed Shoaib, Darshan Singh, Kirsten E. Smith, Marc T. Swogger, Balasingam Vicknasingam, Zachary Walsh, Daniel W. Wang, Marilyn A. Huestis
Publikováno v:
Drug and Alcohol Dependence Reports, Vol 7, Iss , Pp 100142- (2023)
Externí odkaz:
https://doaj.org/article/a7c79b48354f4a0286f0c6a3017b0ed1
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cannabinoids, including those found in cannabis, have shown promise as potential therapeutics for numerous health issues, including pathological pain and diseases that produce an impact on neurological processing and function. Thus, cannabis use for
Externí odkaz:
https://doaj.org/article/186aa05b28b4472b8dd074ffab8f0f44
Autor:
Shyam H. Kamble, Samuel Obeng, Francisco León, Luis F. Restrepo, Tamara I. King, Erin C. Berthold, Siva Rama Raju Kanumuri, Lea R. Gamez-Jimenez, Victoria L.C. Pallares, Avi Patel, Nicholas P. Ho, Aidan Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Abhisheak Sharma, Takato Hiranita
Publikováno v:
J Pharmacol Exp Ther
Mitragynine, an opioidergic alkaloid present in Mitragyna speciosa (kratom), is metabolized by cytochrome P450 3A (CYP3A) to 7-hydroxymitragynine, a more potent opioid receptor agonist. The extent to which conversion to 7-hydroxymitragynine mediates
Autor:
Sushobhan Mukhopadhyay, Sampa Gupta, Jenny L. Wilkerson, Abhisheak Sharma, Lance R. McMahon, Christopher R. McCurdy
Publikováno v:
Current Addiction Reports. 10:304-316
Current and Future Potential Impact of COVID-19 on Kratom (Mitragyna speciosa Korth.) Supply and Use
Autor:
Darshan Singh, Paula N. Brown, Eduardo Cinosi, Ornella Corazza, Jack E. Henningfield, Albert Garcia-Romeu, Christopher R. McCurdy, Lance R. McMahon, Walter C. Prozialeck, Kirsten E. Smith, Marc T. Swogger, Charles Veltri, Zach Walsh, Oliver Grundmann
Publikováno v:
Frontiers in Psychiatry, Vol 11 (2020)
Kratom (Mitragyna speciosa Korth., Rubiaceae) is native to and has traditional use in Southeast Asia. The number of kratom users outside of Southeast Asia has increased significantly in recent decades with use spreading to the Unites States (US) and
Externí odkaz:
https://doaj.org/article/ea0481cf8bb2446cb1a319424c51a8ec
Publikováno v:
Behavioural pharmacology. 33(6)
Baclofen and γ-hydroxybutyrate (GHB) exert γ-aminobutyric acid (GABA)B receptor agonism and have therapeutic utility but possess different pharmacological activities. We examined whether separate groups of mice could be trained to discriminate eith
Publikováno v:
Brain and Behavior, Vol 10, Iss 4, Pp n/a-n/a (2020)
Abstract Objectives There is a long‐standing interest in developing nicotinic acetylcholine receptor (nAChR) antagonists for concomitant use with nAChR agonists (e.g., nicotine replacement) as complementary smoking cessation aids. Previous studies
Externí odkaz:
https://doaj.org/article/2e4f30b85dcb4f8bbc4d43e48641c945