Zobrazeno 1 - 10
of 4 102
pro vyhledávání: '"Lance R"'
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114486- (2024)
Summary: Skin/soft tissue infections (SSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) pose a major healthcare burden. Distinct inflammatory and resolution phases comprise the host immune response to SSTIs. Resolution is a myeloid
Externí odkaz:
https://doaj.org/article/53944c11fa0c413bb30962c2bd36741e
Autor:
Christopher J. Genito, Benjamin P. Darwitz, Callista P. Reber, Nathaniel J. Moorman, Christina L. Graves, Andrew J. Monteith, Lance R. Thurlow
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Mammalian target of rapamycin (mTOR) is a key regulator of metabolism in the mammalian cell. Here, we show the essential role for mTOR signaling in the immune response to bacterial infection. Inhibition of mTOR during infection with Staphylo
Externí odkaz:
https://doaj.org/article/85f1b74089964411967363528312ce13
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new therapies. New migraine therapeutics are needed to address the current deficiencies that exist in the efficacy and adherence rate o
Externí odkaz:
https://doaj.org/article/b546ac27c15946b2960427b79b569952
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0309398 (2024)
For many cancer patients tumor burden negatively impacts quality of life due to associated pain onset. Neuropathic pain is commonly associated with late cancer stages, and is resultant of tumor metastasis to bone, herein referred to as cancer-induced
Externí odkaz:
https://doaj.org/article/65fad567637c4389aee424899fe9a082
Autor:
Christopher J. Genito, Benjamin P. Darwitz, Matthew A. Greenwald, Matthew C. Wolfgang, Lance R. Thurlow
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Diabetes is associated with several health consequences, including increased susceptibility to more frequent and severe infections. Bacterial infections associated with diabetes are typically polymicrobial, with Staphylococcus aureus and Pse
Externí odkaz:
https://doaj.org/article/0a7a155c62984de4a64207e12cf737c5
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract An ongoing healthcare debate is whether controlling hospital-acquired infection (HAI) from methicillin-resistant Staphylococcus aureus (MRSA) will result in lowering the global HAI rate, or if MRSA will simply be replaced by another pathogen
Externí odkaz:
https://doaj.org/article/d5922d8734404b75af9a79508215cdfc
Autor:
Kevin Luque-Sanchez, Jasmine Felix, Joshua Bilbrey, Luis Restrepo, Morgan Reeves, Lance R. McMahon, Jenny L. Wilkerson
Publikováno v:
Advances in Drug and Alcohol Research, Vol 3 (2023)
Nicotine is the primary psychoactive component responsible for maintaining tobacco dependence in humans. Chronic pain is often a consequence of tobacco-related pathologies, and the development of a dual therapeutic that could treat chronic pain and t
Externí odkaz:
https://doaj.org/article/0e05576652064312b1cedf7713cc1043
Autor:
Jack E. Henningfield, Marek C. Chawarski, Albert Garcia-Romeu, Oliver Grundmann, Norsyifa Harun, Zurina Hassan, Christopher R. McCurdy, Lance R. McMahon, Abhisheak Sharma, Mohammed Shoaib, Darshan Singh, Kirsten E. Smith, Marc T. Swogger, Balasingam Vicknasingam, Zachary Walsh, Daniel W. Wang, Marilyn A. Huestis
Publikováno v:
Drug and Alcohol Dependence Reports, Vol 7, Iss , Pp 100142- (2023)
Externí odkaz:
https://doaj.org/article/a7c79b48354f4a0286f0c6a3017b0ed1
Autor:
Andrew J. Siladi, Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock, David K. Flaherty, Shelly L. Lorey, Gregory C. Howard, Stephen W. Fesik, April M. Weissmiller, Qi Liu, William P. Tansey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 ha
Externí odkaz:
https://doaj.org/article/4970649d70db445fb70eaa8e823937b6
Publikováno v:
Frontiers in Fungal Biology, Vol 4 (2023)
The pathogen Ophidiomyces ophidiicola, widely known as the primary cause of snake fungal disease (SFD) has been detected in Texas’s naïve snakes. Our team set out to characterize O. ophidiicola’s spread in eastern Texas. From December 2018 until
Externí odkaz:
https://doaj.org/article/abcd84d444aa4976a8166b14734d6e8e