Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lance J Stewart"'
Autor:
Jedediah M Singer, Scott Novotney, Devin Strickland, Hugh K Haddox, Nicholas Leiby, Gabriel J Rocklin, Cameron M Chow, Anindya Roy, Asim K Bera, Francis C Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M Chidyausiku, Alex Ford, Ethan Ho, Alexander Zaitzeff, Craig O Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J Stewart, David Baker, Eric Klavins
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265020 (2022)
Engineered proteins generally must possess a stable structure in order to achieve their designed function. Stable designs, however, are astronomically rare within the space of all possible amino acid sequences. As a consequence, many designs must be
Externí odkaz:
https://doaj.org/article/7aded064f9274cf1893c7889f59dfe6b
Autor:
Loren Baugh, Larry A Gallagher, Rapatbhorn Patrapuvich, Matthew C Clifton, Anna S Gardberg, Thomas E Edwards, Brianna Armour, Darren W Begley, Shellie H Dieterich, David M Dranow, Jan Abendroth, James W Fairman, David Fox, Bart L Staker, Isabelle Phan, Angela Gillespie, Ryan Choi, Steve Nakazawa-Hewitt, Mary Trang Nguyen, Alberto Napuli, Lynn Barrett, Garry W Buchko, Robin Stacy, Peter J Myler, Lance J Stewart, Colin Manoil, Wesley C Van Voorhis
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53851 (2013)
BACKGROUND:The genus Burkholderia includes pathogenic gram-negative bacteria that cause melioidosis, glanders, and pulmonary infections of patients with cancer and cystic fibrosis. Drug resistance has made development of new antimicrobials critical.
Externí odkaz:
https://doaj.org/article/318d4103a02443b8b18e41dab9bdf5d6
Autor:
Thomas E Edwards, Isabelle Phan, Jan Abendroth, Shellie H Dieterich, Amir Masoudi, Wenjin Guo, Stephen N Hewitt, Angela Kelley, David Leibly, Mitch J Brittnacher, Bart L Staker, Samuel I Miller, Wesley C Van Voorhis, Peter J Myler, Lance J Stewart
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Pathogenic bacteria adhere to the host cell surface using a family of outer membrane proteins called Trimeric Autotransporter Adhesins (TAAs). Although TAAs are highly divergent in sequence and domain structure, they are all conceptually comprised of
Externí odkaz:
https://doaj.org/article/872147d5390e4439b21de6e71d990d81
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Ether-à-go-go (EAG) channels are expressed throughout the central nervous system and are also crucial regulators of cell cycle and tumor progression. The large intracellular amino- and carboxy- terminal domains of EAG1 each share similarity with kno
Externí odkaz:
https://doaj.org/article/7b459e9e41184f98a65b4cd218cec28c
Autor:
Shinya Yamada, Masato Hatta, Bart L Staker, Shinji Watanabe, Masaki Imai, Kyoko Shinya, Yuko Sakai-Tagawa, Mutsumi Ito, Makoto Ozawa, Tokiko Watanabe, Saori Sakabe, Chengjun Li, Jin Hyun Kim, Peter J Myler, Isabelle Phan, Amy Raymond, Eric Smith, Robin Stacy, Chairul A Nidom, Simon M Lank, Roger W Wiseman, Benjamin N Bimber, David H O'Connor, Gabriele Neumann, Lance J Stewart, Yoshihiro Kawaoka
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001034 (2010)
Two amino acids (lysine at position 627 or asparagine at position 701) in the polymerase subunit PB2 protein are considered critical for the adaptation of avian influenza A viruses to mammals. However, the recently emerged pandemic H1N1 viruses lack
Externí odkaz:
https://doaj.org/article/8fe7cb48869b484fa343e34b271f36e4
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 10, p e1000530 (2009)
Externí odkaz:
https://doaj.org/article/8586d7d2adcb45fbb35369c070fe4487
Autor:
Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C. Kraft, Jing Li, Viet Q. Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P. Daniel Poulson, Garrett E. Casper, Mary L. Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C. Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M. Chow, Max R. Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K. Finch, David Lowe, Asim K. Bera, Gustavo Matute-Bello, Timothy P. Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R. Cochran, Lance J. Stewart, Melody G. Campbell, Pam M. Van Ry, Timothy Springer, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between homologous αvβ6 and αvβ8 and other RGD integri
Externí odkaz:
https://doaj.org/article/e3c311aafe5446188603fdc35eee2511
Autor:
Parisa Hosseinzadeh, Paris R. Watson, Timothy W. Craven, Xinting Li, Stephen Rettie, Fátima Pardo-Avila, Asim K. Bera, Vikram Khipple Mulligan, Peilong Lu, Alexander S. Ford, Brian D. Weitzner, Lance J. Stewart, Adam P. Moyer, Maddalena Di Piazza, Joshua G. Whalen, Per Jr. Greisen, David W. Christianson, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cyclic peptides are of particular interest due to their pharmacological properties, but their design for binding to a target protein is challenging. Here, the authors present a computational “anchor extension” methodology for de novo design of cy
Externí odkaz:
https://doaj.org/article/603d7c9cce674f14a81d38644247320d
Autor:
Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance J. Stewart, Max Crispin, David C. Montefiori, David Baker, John P. Moore, Per Johan Klasse, Andrew B. Ward, Neil P. King, Rogier W. Sanders
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine im
Externí odkaz:
https://doaj.org/article/3f361bf123134e9fb806b778a2f53c71
Autor:
Daniel L. Flynn, Michael Clare, Lance J. Stewart, Lawrence Chun, Karen M. Yates, Subha Vogeti, Lakshminarayana Vogeti, Hanumaiah Telikepalli, Thiwanka Samarakoon, Thomas J. Rutkoski, William C. Patt, Tristan W. Patt, Wei-Ping Lu, Molly M. Hood, Carol L. Ensinger, Timothy M. Caldwell, R. John Booth, Yu Mi Ahn, Scott C. Wise, Benjamin A. Turner, Cynthia B. Leary, Michael D. Kaufman, Bryan D. Smith
Altiratinib (DCC-2701) was designed based on the rationale of engineering a single therapeutic agent able to address multiple hallmarks of cancer (1). Specifically, altiratinib inhibits not only mechanisms of tumor initiation and progression, but als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a49f1af80ca00d7cc02eb5848964921
https://doi.org/10.1158/1535-7163.c.6536815.v1
https://doi.org/10.1158/1535-7163.c.6536815.v1