Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Lance E Lanyon"'
Autor:
Gabriel L Galea, Sion eHannuna, Lee B Meakin, Peter J Delisser, Lance E Lanyon, Joanna S Price
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
Investigations into the effect of (re)modelling stimuli on cortical bone in rodents normally rely on analysis of changes in bone mass and architecture at a narrow cross-sectional site. However, it is well established that the effects of axial loading
Externí odkaz:
https://doaj.org/article/398b112e49f345138cd50e4871e9dcc0
Autor:
Henry Todd, Gabriel L Galea, Lee B Meakin, Peter J Delisser, Lance E Lanyon, Sara H Windahl, Joanna S Price
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140260 (2015)
Genome Wide Association Studies suggest that Wnt16 is an important contributor to the mechanisms controlling bone mineral density, cortical thickness, bone strength and ultimately fracture risk. Wnt16 acts on osteoblasts and osteoclasts and, in corti
Externí odkaz:
https://doaj.org/article/1971d36171094bf2884b381b01114b7a
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2014)
Changing loading regimens by natural means such as exercise, with or without interference such as osteotomy, has provided useful information on the structure:function relationship in bone tissue. However, the greatest precision in defining those aspe
Externí odkaz:
https://doaj.org/article/0a210318c8b04e2cbaa3d224daa7ffbe
Autor:
Behzad Javaheri, Andrew Sunters, Gul Zaman, Rosemary F L Suswillo, Leanne K Saxon, Lance E Lanyon, Joanna S Price
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35726 (2012)
Although Lrp5 is known to be an important contributor to the mechanisms regulating bone mass, its precise role remains unclear. The aim of this study was to establish whether mutations in Lrp5 are associated with differences in the growth and/or apop
Externí odkaz:
https://doaj.org/article/6f5d8c4da1e54e549ee463df8aa0b3e0
Publikováno v:
Bone
Galea, G L, Lanyon, L E & Price, J S 2017, ' Sclerostin's role in bone's adaptive response to mechanical loading ', Bone, vol. 96, pp. 38-44 . https://doi.org/10.1016/j.bone.2016.10.008
Galea, G L, Lanyon, L E & Price, J S 2017, ' Sclerostin's role in bone's adaptive response to mechanical loading ', Bone, vol. 96, pp. 38-44 . https://doi.org/10.1016/j.bone.2016.10.008
Mechanical loading is the primary functional determinant of bone mass and architecture, and osteocytes play a key role in translating mechanical signals into (re)modelling responses. Although the precise mechanisms remain unclear, Wnt signalling path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80599814f3c1ef4e8389341b0e4d83dc
Autor:
Christopher R. Paradise, Joanna S. Price, Gabriel L. Galea, Andre J. van Wijnen, Emily T. Camilleri, Gary S. Stein, Lance E. Lanyon, Amel Dudakovic, Lee B Meakin, Hanna Taipaleenmäki
Publikováno v:
Gene: X
Galea, G L, Paradise, C R, Meakin, L B, Camilleri, E T, Taipaleenmaki, H, Stein, G S, Lanyon, L E, Price, J S, van Wijnen, A J & Dudakovic, A 2020, ' Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 ', Gene, vol. 763S, 100027, pp. 100027 . https://doi.org/10.1016/j.gene.2020.100027
Gene: X, Vol 5, Iss, Pp 100027-(2020)
Galea, G L, Paradise, C R, Meakin, L B, Camilleri, E T, Taipaleenmaki, H, Stein, G S, Lanyon, L E, Price, J S, van Wijnen, A J & Dudakovic, A 2020, ' Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 ', Gene, vol. 763S, 100027, pp. 100027 . https://doi.org/10.1016/j.gene.2020.100027
Gene: X, Vol 5, Iss, Pp 100027-(2020)
Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25bf36d9a55ee08ac308c9e986aaf2e
http://europepmc.org/articles/PMC7285908
http://europepmc.org/articles/PMC7285908
Autor:
Sara H Windahl, Joanna S. Price, Lee B Meakin, Peter J Delisser, Lance E. Lanyon, Gabriel L. Galea
The primary aim of bone anabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. This is naturally achieved by mechanical loading of the young healthy skeleton. However, these bone anabolic resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ea831793dc05ec128abe22c25a0acf
Autor:
Rosemary F L, Suswillo, Behzad, Javaheri, Simon C F, Rawlinson, Gary P, Dowthwaite, Lance E, Lanyon, Andrew A, Pitsillides
Publikováno v:
Cell Biochemistry and Function
Identifying mechanisms by which cells of the osteoblastic lineage communicate in vivo is complicated by the mineralised matrix that encases osteocytes, and thus, vital mechanoadaptive processes used to achieve load-bearing integrity remain unresolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ae889f4c1f44f2f15d2761febd80d54b
http://europepmc.org/articles/PMC5299599
http://europepmc.org/articles/PMC5299599
Autor:
Claes Ohlsson, Klara Sjögren, Petra Henning, Leanne Saxon, Marie K Lagerquist, Gabriel L. Galea, Anna E Börjesson, Lance E. Lanyon, Joanna S. Price, Baruch Frenkel, Maria Cristina Antal, Lee B Meakin, Andrée Krust, Pierre Chambon, Sara H Windahl, Cecilia Engdahl, Ulf H. Lerner
Publikováno v:
Journal of Bone and Mineral Research
Windahl, S H, Saxon, L, Borjesson, A, Lagerquist, M K, Frenkel, B, Henning, P, Lerner, U H, Galea, G L, Meakin, L B, Engdahl, C, Sjogren, K, Antal, M C, Krust, A, Chambon, P, Lanyon, L E, Price, J S & Ohlsson, C 2013, ' Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2 ', Journal of Bone and Mineral Research, vol. 28, no. 2, pp. 291-301 . https://doi.org/10.1002/jbmr.1754
Windahl, S H, Saxon, L, Borjesson, A, Lagerquist, M K, Frenkel, B, Henning, P, Lerner, U H, Galea, G L, Meakin, L B, Engdahl, C, Sjogren, K, Antal, M C, Krust, A, Chambon, P, Lanyon, L E, Price, J S & Ohlsson, C 2013, ' Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2 ', Journal of Bone and Mineral Research, vol. 28, no. 2, pp. 291-301 . https://doi.org/10.1002/jbmr.1754
Estrogen receptor-α (ERα) is crucial for the adaptive response of bone to loading but the role of endogenous estradiol (E2) for this response is unclear. To determine in vivo the ligand dependency and relative roles of different ERα domains for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a05cc973194c078611236576347aa91
http://europepmc.org/articles/PMC3575695
http://europepmc.org/articles/PMC3575695
Autor:
Lee B Meakin, Andre J. Van Wijnen, Joanna S. Price, Hanna Taipaleenmaki, Noureddine Zebda, Andrew Sunters, Gary S. Stein, Gabriel L. Galea, Lance E. Lanyon, Toshihiro Sugiyama
Publikováno v:
The Journal of Biological Chemistry
Galea, G L, Meakin, L B, Sugiyama, T, Zebda, N, Sunters, A, Taipaleenmaki, H, Stein, G S, van Wijnen, A J, Lanyon, L E & Price, J S 2013, ' Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost is Mediated by Estrogen Receptor β ', Journal of Biological Chemistry, vol. 288, no. 13, pp. 9035-9048 . https://doi.org/10.1074/jbc.M112.405456
Galea, G L, Meakin, L B, Sugiyama, T, Zebda, N, Sunters, A, Taipaleenmaki, H, Stein, G S, van Wijnen, A J, Lanyon, L E & Price, J S 2013, ' Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost is Mediated by Estrogen Receptor β ', Journal of Biological Chemistry, vol. 288, no. 13, pp. 9035-9048 . https://doi.org/10.1074/jbc.M112.405456
Background: Strain and estrogens down-regulate Sost/sclerostin and stimulate osteoblastic proliferation. Results: ERα inhibition prevents proliferation. ERβ inhibition prevents Sost down-regulation by strain or estradiol. Sclerostin prevents prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7de7f0d46316a411e52e930e1774f46
http://europepmc.org/articles/PMC3610976
http://europepmc.org/articles/PMC3610976