Výsledky vyhledávání - "Lance D. Mikus"

Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunction

Autor: Louis A. Rosenthal, Anne G. Mosser, Robert F. Lemanske, Kristine Grindle, James E. Gern, Lance D. Mikus, Ronald L. Sorkness

Publikováno v: Journal of Allergy and Clinical Immunology. 110:607-609

After viral bronchiolitis at an early age, a chronic asthma-like syndrome develops in BN, but not F344, rats. We hypothesized that the BN strain is less effective at clearing virus from the involved tissues. Weanling BN and F344 rats were inoculated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d4aee420f2cc4c1e38bacbea324f5b
https://doi.org/10.1067/mai.2002.128241

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Viral infections, cytokine dysregulation and the origins of childhood asthma and allergic diseases

Publikováno v: The Pediatric infectious disease journal. 24

Background: The origins of asthma and allergic disease begin in early life for many individuals. It is vital to understand the factors and/or events leading to their development. Methods: The Childhood Origins of Asthma project evaluated children at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a4ebbdd9370632e21be0bbd7c27ee1
https://pubmed.ncbi.nlm.nih.gov/16378042

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Effects of dog ownership and genotype on immune development and atopy in infancy

Publikováno v: The Journal of allergy and clinical immunology. 113(2)

Background Exposure to furred pets might confer protection against the development of allergic sensitization through a mechanism that is incompletely understood. Objective The objective of this study was to determine the effects of pet exposure and g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba197acc03d6fa469aa5c34ef1402cc7
https://pubmed.ncbi.nlm.nih.gov/14767447

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Attenuated innate mechanisms of interferon-gamma production in rats susceptible to postviral airway dysfunction

Autor: Louis A. Rosenthal, Anne G. Mosser, Ronald L. Sorkness, Lance D. Mikus, Amjad Tuffaha, Robert F. Lemanske

Publikováno v: American journal of respiratory cell and molecular biology. 30(5)

After Sendai virus (SeV)-induced bronchiolitis as weanlings, BN, but not F344, rats develop a postbronchiolitis asthma-like phenotype, which can be prevented by supplemental interferon (IFN)-gamma treatment. We have shown that splenocytes from BN wea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71524cfc9eb5687fc1a9b1c513004e0
https://pubmed.ncbi.nlm.nih.gov/14592927

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Developmental cytokine response profiles and the clinical and immunologic expression of atopy during the first year of life

Autor: Rebekah Hamilton, Lance D. Mikus, Stephanie Gilbertson-White, Christopher J. Tisler, Kirstin T Carlson-Dakes, Kelly S. Anklam, James E. Gern, Debbie Yoshihara, Elizabeth L. Anderson, Abhik Bhattacharya, William A Neaville, Kathy A. Roberg, Kiva J. Adler, Louis A. Rosenthal, Douglas F. DaSilva, Robert F. Lemanske, Ronald E. Gangnon

Publikováno v: The Journal of allergy and clinical immunology. 112(4)

Background Allergic diseases have been linked to abnormal patterns of immune development, and this has stimulated efforts to define the precise patterns of cytokine dysregulation that are associated with specific atopic phenotypes. Objective Cytokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8488f23cc918c16e97ba77fe9b43894
https://pubmed.ncbi.nlm.nih.gov/14564354

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Chronic postbronchiolitis airway instability induced with anti-IFN-gamma antibody in F344 rats

Autor: Lance D. Mikus, William L. Castleman, Robert F. Lemanske, Anne G. Mosser, Ronald L. Sorkness

Publikováno v: Pediatric research. 52(3)

Analogous to childhood-onset asthma in humans, rats may develop a chronic asthmalike phenotype, depending on their genetic background and the age at which they experience a viral airway injury. Brown Norway rats develop a postbronchiolitis asthmalike

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b77c3dea3d3538e5832b000d9a2c788
https://pubmed.ncbi.nlm.nih.gov/12193672

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Reduced interferon-gamma secretion by natural killer cells from rats susceptible to postviral chronic airway dysfunction

Autor: Louis A. Rosenthal, Lance D. Mikus, Ronald L. Sorkness, Robert F. Lemanske

Publikováno v: American journal of respiratory cell and molecular biology. 24(1)

After parainfluenza type 1 (Sendai) virus infection as weanlings, Brown Norway (BN), unlike Fischer 344 (F344), rats develop an asthma-like phenotype. Reduced postinfection interferon (IFN)-gamma levels in bronchoalveolar lavage fluid from BN weanlin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8579f9ffdd11b7c6eed78559df3c378e
https://pubmed.ncbi.nlm.nih.gov/11152653

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GM-CSF and Flt-3 ligand counteract a deficient capacity for respiratory virus-induced IFN-$gamma; production*1

Autor: Lance D. Mikus, Ronald L. Sorkness, Louis A. Rosenthal, Robert F. Lemanske

Publikováno v: Journal of Allergy and Clinical Immunology. 113:S271

Rationale After Sendai virus-induced bronchiolitis as weanlings, BN, unlike F344, rats develop a postbronchiolitis asthma-like phenotype, which is prevented by IFN-γ therapy. Innate mechanisms of Sendai virus-induced IFN-γ production, which are dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78b98528bf7ac98db96d7718ad7bfcdb
https://doi.org/10.1016/j.jaci.2004.01.444

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