Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Lance C. Kam"'
Publikováno v:
BioMedInformatics, Vol 4, Iss 2, Pp 1144-1154 (2024)
Immune cell function varies tremendously between individuals, posing a major challenge to emerging cellular immunotherapies. This report pursues the use of cell morphology as an indicator of high-level T cell function. Short-term spreading of T cells
Externí odkaz:
https://doaj.org/article/0d8fe5dcde934ab8abf24d64e9a27b82
Autor:
Mitchell S. Wang, Yuesong Hu, Elisa E. Sanchez, Xihe Xie, Nathan H. Roy, Miguel de Jesus, Benjamin Y. Winer, Elizabeth A. Zale, Weiyang Jin, Chirag Sachar, Joanne H. Lee, Yeonsun Hong, Minsoo Kim, Lance C. Kam, Khalid Salaita, Morgan Huse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/69988d359ee64fb2a6052a6711250dd3
Autor:
Mitchell S. Wang, Yuesong Hu, Elisa E. Sanchez, Xihe Xie, Nathan H. Roy, Miguel de Jesus, Benjamin Y. Winer, Elizabeth A. Zale, Weiyang Jin, Chirag Sachar, Joanne H. Lee, Yeonsun Hong, Minsoo Kim, Lance C. Kam, Khalid Salaita, Morgan Huse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with infected or transformed target cells and then secreting cytotoxic perforin and granzyme into the synaptic space, with potent and specific killing achieved by th
Externí odkaz:
https://doaj.org/article/714e2c54408043c7a7f481a9f4492c05
Autor:
Chirag Sachar, Lance C. Kam
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The ability of cells to recognize and respond to the mechanical properties of their environment is of increasing importance in T cell physiology. However, initial studies in this direction focused on planar hydrogel and elastomer surfaces, presenting
Externí odkaz:
https://doaj.org/article/bb58f045de4e4380a42f989c1930d67d
Autor:
Joanne H. Lee, Shuai Shao, Michelle Kim, Stacey M. Fernandes, Jennifer R. Brown, Lance C. Kam
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Expansion of an initial population of T cells is essential for cellular immunotherapy. In Chronic Lymphocytic Leukemia (CLL), expansion is often complicated by lack of T cell proliferation, as these cells frequently show signs of exhaustion. This rep
Externí odkaz:
https://doaj.org/article/8151146dfa964a8099b80ca55abdc0b9
Autor:
Viveka Mayya, Edward Judokusumo, Enas Abu Shah, Christopher G. Peel, Willie Neiswanger, David Depoil, David A. Blair, Chris H. Wiggins, Lance C. Kam, Michael L. Dustin
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 340-349 (2018)
Summary: T cells engage in two modes of interaction with antigen-presenting surfaces: stable synapses and motile kinapses. Although it is surmised that durable interactions of T cells with antigen-presenting cells involve synapses, in situ 3D imaging
Externí odkaz:
https://doaj.org/article/dd677668e2df4a0db8e025ca66ed90b4
Publikováno v:
Biomaterials. 292
Regulatory T cells (Tregs) provide an essential tolerance mechanism to suppress the immune response. Induced Tregs hold the potential to treat autoimmune diseases in adoptive therapy and can be produced with stimulating signals to CD3 and CD28 in pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc3c0c8e652348c162bf2d53d5aee8f
https://pubmed.ncbi.nlm.nih.gov/36455488
https://pubmed.ncbi.nlm.nih.gov/36455488
Autor:
Khalid Salaita, M. De Jesus, E. Sanchez, Xihe Xie, M. S. Wang, Yi-Juan Hu, Y. Hong, N. H. Roy, Weiyang Jin, Morgan Huse, Minsoo Kim, JinHyung Lee, Lance C. Kam
The secretory output of cell-cell interfaces must be tightly controlled in space and time to ensure functional efficacy. This is particularly true for the cytotoxic immune synapse (IS), the stereotyped junction formed between a cytotoxic lymphocyte a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::158f0efbc021489a800af65164c1d376
https://doi.org/10.1101/2021.10.02.462778
https://doi.org/10.1101/2021.10.02.462778
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Expansion of an initial population of T cells is essential for cellular immunotherapy. In Chronic Lymphocytic Leukemia (CLL), expansion is often complicated by lack of T cell proliferation, as these cells frequently show signs of exhaustion. This rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e0033e56a7447325b60fc2267fb8e9
https://pubmed.ncbi.nlm.nih.gov/33898440
https://pubmed.ncbi.nlm.nih.gov/33898440
Publikováno v:
Adv Biosyst
This report examines how sensing of substrate topography can be used to modulate T cell activation, a key coordinating step in the adaptive immune response. Inspired by the native T cell-antigen presenting cell interface, micrometer scale pits with v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cb21cd2feac10b35c79a36c9ca0b98
https://pubmed.ncbi.nlm.nih.gov/32744809
https://pubmed.ncbi.nlm.nih.gov/32744809