Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Lance C Kam"'
Autor:
Dennis Jinglun Yuan, Shuai Shao, Joanne H Lee, Stacey M Fernandes, Jennifer R Brown, Lance C Kam
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 15-15 (2020)
OBJECTIVES/GOALS: Utilize polymer-based fiber scaffolds and machine learning methods applied to patient biomarker data to enhance and personalize T cell expansion and production for T cell therapy in chronic lymphocytic leukemia. METHODS/STUDY POPULA
Externí odkaz:
https://doaj.org/article/0125acbaae754e69a86ddc6c95cb1467
Autor:
Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin
Publikováno v:
eLife, Vol 4 (2015)
Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation.
Externí odkaz:
https://doaj.org/article/f960d6f2019e4067b92e0cb40238c62c
Autor:
Mitchell S. Wang, Yuesong Hu, Elisa E. Sanchez, Xihe Xie, Nathan H. Roy, Miguel de Jesus, Benjamin Y. Winer, Elizabeth A. Zale, Weiyang Jin, Chirag Sachar, Joanne H. Lee, Yeonsun Hong, Minsoo Kim, Lance C. Kam, Khalid Salaita, Morgan Huse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with infected or transformed target cells and then secreting cytotoxic perforin and granzyme into the synaptic space, with potent and specific killing achieved by th
Externí odkaz:
https://doaj.org/article/714e2c54408043c7a7f481a9f4492c05
Autor:
Chirag Sachar, Lance C. Kam
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The ability of cells to recognize and respond to the mechanical properties of their environment is of increasing importance in T cell physiology. However, initial studies in this direction focused on planar hydrogel and elastomer surfaces, presenting
Externí odkaz:
https://doaj.org/article/bb58f045de4e4380a42f989c1930d67d
Autor:
Joanne H. Lee, Shuai Shao, Michelle Kim, Stacey M. Fernandes, Jennifer R. Brown, Lance C. Kam
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Expansion of an initial population of T cells is essential for cellular immunotherapy. In Chronic Lymphocytic Leukemia (CLL), expansion is often complicated by lack of T cell proliferation, as these cells frequently show signs of exhaustion. This rep
Externí odkaz:
https://doaj.org/article/8151146dfa964a8099b80ca55abdc0b9
Publikováno v:
Biomaterials. 292
Regulatory T cells (Tregs) provide an essential tolerance mechanism to suppress the immune response. Induced Tregs hold the potential to treat autoimmune diseases in adoptive therapy and can be produced with stimulating signals to CD3 and CD28 in pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc3c0c8e652348c162bf2d53d5aee8f
https://pubmed.ncbi.nlm.nih.gov/36455488
https://pubmed.ncbi.nlm.nih.gov/36455488
Autor:
Khalid Salaita, M. De Jesus, E. Sanchez, Xihe Xie, M. S. Wang, Yi-Juan Hu, Y. Hong, N. H. Roy, Weiyang Jin, Morgan Huse, Minsoo Kim, JinHyung Lee, Lance C. Kam
The secretory output of cell-cell interfaces must be tightly controlled in space and time to ensure functional efficacy. This is particularly true for the cytotoxic immune synapse (IS), the stereotyped junction formed between a cytotoxic lymphocyte a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::158f0efbc021489a800af65164c1d376
https://doi.org/10.1101/2021.10.02.462778
https://doi.org/10.1101/2021.10.02.462778
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Expansion of an initial population of T cells is essential for cellular immunotherapy. In Chronic Lymphocytic Leukemia (CLL), expansion is often complicated by lack of T cell proliferation, as these cells frequently show signs of exhaustion. This rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e0033e56a7447325b60fc2267fb8e9
https://pubmed.ncbi.nlm.nih.gov/33898440
https://pubmed.ncbi.nlm.nih.gov/33898440
Publikováno v:
Adv Biosyst
This report examines how sensing of substrate topography can be used to modulate T cell activation, a key coordinating step in the adaptive immune response. Inspired by the native T cell-antigen presenting cell interface, micrometer scale pits with v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cb21cd2feac10b35c79a36c9ca0b98
https://pubmed.ncbi.nlm.nih.gov/32744809
https://pubmed.ncbi.nlm.nih.gov/32744809
Publikováno v:
Journal of Biomedical Materials Research Part A. 106:3001-3008
The immune system maintains a balance between protection and tolerance. Regulatory T cells (Tregs) function as a vital tolerance mechanism in the immune system to suppress effector immune cells. Additionally, Tregs can be utilized as a form of immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5caee355c192b82fd6befa200aa77782
https://doi.org/10.1002/jbm.a.36489
https://doi.org/10.1002/jbm.a.36489