Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lance A Stechschulte"'
Autor:
Vipula Kolli, Lance A Stechschulte, Abigail R Dowling, Sima Rahman, Piotr J Czernik, Beata Lecka-Czernik
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96323 (2014)
Peroxisome proliferator activated receptor gamma (PPARγ) controls both glucose metabolism and an allocation of marrow mesenchymal stem cells (MSCs) toward osteoblast and adipocyte lineages. Its activity is determined by interaction with a ligand whi
Externí odkaz:
https://doaj.org/article/af179a5352ae4948a481dd6c3308e4fe
Autor:
Beata Lecka-Czernik, Lance A. Stechschulte, Piotr J. Czernik, Shermel B. Sherman, Shilong Huang, Amrei Krings
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
Marrow adipose tissue (MAT) is unique with respect to origin, metabolism, and function. MAT is characterized with high heterogeneity which correlates with skeletal location and bone metabolism. This fat depot is also highly sensitive to various hormo
Externí odkaz:
https://doaj.org/article/d81f0a3e699f4a93b99f4f1804477719
Autor:
Irina Budunova, Joel T. Dudley, Edwin R. Sanchez, Pankaj Bhalla, Lance A. Stechschulte, Weinian Shou, Ben Readhead, Gleb Baida, Alexander Yemelyanov
Publikováno v:
Oncotarget
FKBP51 (FK506-binding protein 51) is a known co-chaperone and regulator of the glucocorticoid receptor (GR), which usually attenuates its activity. FKBP51 is one of the major GR target genes in skin, but its role in clinical effects of glucocorticoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64804149904e7a2fa2fe0c111166d02f
https://doi.org/10.18632/oncotarget.26194
https://doi.org/10.18632/oncotarget.26194
Autor:
Jie Zheng, Cesar A. Corzo, Theodore M. Kamenecka, Beata Lecka-Czernik, Patrick R. Griffin, F.N. Tausif, Lance A. Stechschulte, John B. Bruning, David Marciano, Alice Asteian, Z.C. Rotter, Piotr J. Czernik, Clifford J. Rosen
Publikováno v:
EBioMedicine
EBioMedicine, Vol 10, Iss C, Pp 174-184 (2016)
EBioMedicine, Vol 10, Iss C, Pp 174-184 (2016)
The peroxisome proliferator-activated receptor gamma (PPARγ) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f3a885fb852b1c2cb65704621f32de
http://europepmc.org/articles/PMC5006645
http://europepmc.org/articles/PMC5006645
Publikováno v:
Current osteoporosis reports. 16(2)
The goal of this review is to summarize recent findings on marrow adipose tissue (MAT) function and to discuss the possibility of targeting MAT for therapeutic purposes. MAT is characterized with high heterogeneity which may suggest both that marrow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153024afc79ca51c0848f9d7d90c7641
https://pubmed.ncbi.nlm.nih.gov/29460176
https://pubmed.ncbi.nlm.nih.gov/29460176
Publikováno v:
Current molecular biology reports. 3(2)
Post-translational modifications (PTMs), specifically serine phosphorylation, are essential for determination and tuning up an activity of many proteins, including those that are involved in the control of gene transcription. Transcription factors PP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f3e1df37ed0064da8134a65c2c40f7
https://pubmed.ncbi.nlm.nih.gov/29276666
https://pubmed.ncbi.nlm.nih.gov/29276666
Publikováno v:
Molecular and Cellular Endocrinology. 410:35-41
Obesity is generally recognized as a condition which positively influences bone mass and bone mineral density (BMD). Positive effect of high body mass index (BMI) on bone has been recognized as a result of increased mechanical loading exerted on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799e781a38f5ca5c2cfa75b6b7ee71e5
https://doi.org/10.1016/j.mce.2015.01.001
https://doi.org/10.1016/j.mce.2015.01.001
Autor:
Lance A. Stechschulte, Simona S. Ghanem, Weinian Shou, Terry D. Hinds, Sonia M. Najjar, Edwin R. Sanchez
Publikováno v:
Molecular Endocrinology. 28:1254-1264
FK506-binding protein 51 (FKBP51) is a negative regulator of glucocorticoid receptor-α (GRα), although the mechanism is unknown. We show here that FKBP51 is also a chaperone to peroxisome proliferator–activated receptor-γ (PPARγ), which is esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347d00a7e291a233d40353a25b02dd63
https://doi.org/10.1210/me.2014-1023
https://doi.org/10.1210/me.2014-1023
Autor:
Saja S. Khuder, Edwin R. Sanchez, Lance A. Stechschulte, Sonia M. Najjar, Weinian Shou, Terry D. Hinds
Publikováno v:
Molecular Endocrinology. 28:1265-1275
Glucocorticoid receptor-α (GRα) and peroxisome proliferator–activated receptor-γ (PPARγ) are critical regulators of adipogenic responses. We have shown that FK506-binding protein 51 (FKBP51) represses the Akt-p38 kinase pathway to reciprocally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58af2dee42e0f29e3471571c453f9dad
https://doi.org/10.1210/me.2014-1022
https://doi.org/10.1210/me.2014-1022
Autor:
Charis Eng, Terry D. Hinds, Lance A. Stechschulte, Joseph S. Marino, Leah M. Wuescher, Jennifer W. Hill
Publikováno v:
Journal of Biological Chemistry. 289:17885-17894
Glucocorticoids (GCs) are known inhibitors of proliferation and are commonly prescribed to cancer patients to inhibit tumor growth and induce apoptosis via the glucocorticoid receptor (GR). Because of alternative splicing, the GR exists as two isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6a0eaae5f62818b8c4798932ae4046
https://doi.org/10.1074/jbc.m113.544072
https://doi.org/10.1074/jbc.m113.544072