Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Lance A Johnson"'
Autor:
Yingxue Ren, Xue Wang, Shuwen Zhang, Hongru Hu, Zachary Quicksall, Sangderk Lee, Josh M. Morganti, Lance A. Johnson, Yan W. Asmann, Na Zhao
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Mounting evidence highlights the crucial role of aging in the pathogenesis of Alzheimer's disease (AD). We have previously explored human apoE-targeted replacement mice across different ages and identified distinct molecular pathways driven
Externí odkaz:
https://doaj.org/article/31c2e89d5e3a47eeb8c4e3b0ed33f021
Autor:
Benjamin I. Burke, Jensen Goh, Fatmah A. Albathi, Taylor R. Valentino, Georgia L. Nolt, Jai K. Joshi, Cory M. Dungan, Lance A. Johnson, Yuan Wen, Ahmed Ismaeel, John J. McCarthy
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Apolipoprotein E (ApoE) has been shown to be necessary for proper skeletal muscle regeneration. Consistent with this finding, single-cell RNA-sequencing analyses of skeletal muscle stem cells (MuSCs) revealed that Apoe is a top marker o
Externí odkaz:
https://doaj.org/article/fe9f970a147c4232b8eacab89dcc655a
Autor:
Lesley R. Golden, Lance A. Johnson
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/7083470920fe46b7bb885112748db2fc
Autor:
Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T. Smith, James L. Schwartz, Adeline E. Walsh, Harrison A. Clarke, Danielle S. Goulding, Elizabeth J. Allenger, Gabriella Morillo-Segovia, Cassi M. Friday, Amy A. Gorman, Tara R. Hawkinson, Steven M. MacLean, Holden C. Williams, Ramon C. Sun, Josh M. Morganti, Lance A. Johnson
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112196- (2023)
Summary: The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response: two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bulk,
Externí odkaz:
https://doaj.org/article/e1c00f972cba4194bdc8ecccacd17804
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Apolipoprotein E (APOE) alleles impact pathogenesis and risk for multiple human diseases, making them primary targets for disease treatment and prevention. Previously, we and others reported an association between APOE alleles and the gut mi
Externí odkaz:
https://doaj.org/article/912cb66cf2f246248f163c42787ddf53
Autor:
Brandon C. Farmer, Holden C. Williams, Nicholas A. Devanney, Margaret A. Piron, Grant K. Nation, David J. Carter, Adeline E. Walsh, Rebika Khanal, Lyndsay E. A. Young, Jude C. Kluemper, Gabriela Hernandez, Elizabeth J. Allenger, Rachel Mooney, Lesley R. Golden, Cathryn T. Smith, J. Anthony Brandon, Vedant A. Gupta, Philip A. Kern, Matthew S. Gentry, Josh M. Morganti, Ramon C. Sun, Lance A. Johnson
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)
Abstract Background Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer’s disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of Apolipoprotein E (APOE), the strongest genetic predictor
Externí odkaz:
https://doaj.org/article/cb9c5a3aaabd427e887297119cecd36d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Externí odkaz:
https://doaj.org/article/533280193b5f48b7ba829551de45d15f
Autor:
Hussein N. Yassine, Wade Self, Bilal E. Kerman, Giulia Santoni, NandaKumar Navalpur Shanmugam, Laila Abdullah, Lesley R. Golden, Alfred N. Fonteh, Michael G. Harrington, Johannes Gräff, Gary E. Gibson, Raj Kalaria, Jose A. Luchsinger, Howard H. Feldman, Russell H. Swerdlow, Lance A. Johnson, Benedict C. Albensi, Berislav V. Zlokovic, Rudolph Tanzi, Stephen Cunnane, Cécilia Samieri, Nikolaos Scarmeas, Gene L. Bowman
Publikováno v:
Alzheimer's & Dementia. 19:1041-1066
Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610baf6bd459f153d922cbd98565ac79
https://doi.org/10.1002/alz.12845
https://doi.org/10.1002/alz.12845
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, me
Externí odkaz:
https://doaj.org/article/33275e46c6d44f01839efcf4072f60a4
Autor:
D. Allan Butterfield, Lance A. Johnson
Publikováno v:
Neurobiology of Disease, Vol 139, Iss , Pp 104847- (2020)
Externí odkaz:
https://doaj.org/article/8e925730e24b48bab2ced9470423c712