Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Lance A Davidson"'
Autor:
William Duncan Martinson, Rebecca McLennan, Jessica M Teddy, Mary C McKinney, Lance A Davidson, Ruth E Baker, Helen M Byrne, Paul M Kulesa, Philip K Maini
Publikováno v:
eLife, Vol 12 (2023)
Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this phenomenon remains unclear. Observations of the distribution of the extracellular matrix (ECM)
Externí odkaz:
https://doaj.org/article/2dc117d3186148a4bb07444cc33ce442
Publikováno v:
eLife, Vol 9 (2020)
One of the fundamental gaps in our knowledge of how novel anatomical structures evolve is understanding the origins of the morphogenetic processes that form these features. Here, we traced the cellular development of a recently evolved morphological
Externí odkaz:
https://doaj.org/article/94967ecb1ab1435cb852e134720df8a5
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218021 (2019)
Advanced imaging techniques generate large datasets capable of describing the structure and kinematics of tissue spreading in embryonic development, wound healing, and the progression of many diseases. These datasets can be integrated with mathematic
Externí odkaz:
https://doaj.org/article/11cffe0b55744e1986627fcc7111b99a
Autor:
Torey R Arnold, Joseph H Shawky, Rachel E Stephenson, Kayla M Dinshaw, Tomohito Higashi, Farah Huq, Lance A Davidson, Ann L Miller
Publikováno v:
eLife, Vol 8 (2019)
Cellular forces sculpt organisms during development, while misregulation of cellular mechanics can promote disease. Here, we investigate how the actomyosin scaffold protein anillin contributes to epithelial mechanics in Xenopus laevis embryos. Increa
Externí odkaz:
https://doaj.org/article/b2e8d36113274923811bc67c9beb8534
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 9, p e1006344 (2018)
Filamentous actin (F-actin) and non-muscle myosin II motors drive cell motility and cell shape changes that guide large scale tissue movements during embryonic morphogenesis. To gain a better understanding of the role of actomyosin in vivo, we have d
Externí odkaz:
https://doaj.org/article/a9675180aa804e3cbc674e2bba825af4
Publikováno v:
eLife, Vol 7 (2018)
Indirect evidence suggests that blastopore closure during gastrulation of anamniotes, including amphibians such as Xenopus laevis, depends on circumblastoporal convergence forces generated by the marginal zone (MZ), but direct evidence is lacking. We
Externí odkaz:
https://doaj.org/article/9bc3223876774ae8a850784d92ab25a4
Autor:
Robert D. Hyldahl, Jayson R. Gifford, Lance E. Davidson, Chad R. Hancock, Paul S. Hafen, Allen C. Parcell, Gary W. Mack
Publikováno v:
Experimental Physiology, Vol 109, Iss 2, Pp 165-174 (2024)
Abstract The Tour Divide (TD) is a 4385 km ultra‐endurance bicycle race that follows the continental divide from Canada to Mexico. In this case study, we performed a comprehensive molecular and physiological profile before and after the completion
Externí odkaz:
https://doaj.org/article/0e26490f416c437ba963d772c9064514
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95670 (2014)
Successful completion of development requires coordination of patterning events with morphogenetic movements. Environmental variability challenges this coordination. For example, developing organisms encounter varying environmental temperatures that
Externí odkaz:
https://doaj.org/article/a4b60de639c447fda890e47c4eb61eb5
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14624 (2011)
Embryonic development is guided by a complex and integrated set of stimuli that results in collective system-wide organization that is both time and space regulated. These regulatory interactions result in the emergence of highly functional units, wh
Externí odkaz:
https://doaj.org/article/6f4b224deb27439e9d7332c41b4b1b78
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15359 (2010)
Previous studies suggest that mechanical feedback could coordinate morphogenetic events in embryos. Furthermore, embryonic tissues have complex structure and composition and undergo large deformations during morphogenesis. Hence we expect highly non-
Externí odkaz:
https://doaj.org/article/b318cc5b8f6f438aa1a6f5fc310bc877