Zobrazeno 1 - 10
of 864
pro vyhledávání: '"Lana E"'
Immunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides
Autor:
Humberto J. Ferreira, Brian J. Stevenson, HuiSong Pak, Fengchao Yu, Jessica Almeida Oliveira, Florian Huber, Marie Taillandier-Coindard, Justine Michaux, Emma Ricart-Altimiras, Anne I. Kraemer, Lana E. Kandalaft, Daniel E. Speiser, Alexey I. Nesvizhskii, Markus Müller, Michal Bassani-Sternberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Circular RNAs (circRNAs) are covalently closed non-coding RNAs lacking the 5’ cap and the poly-A tail. Nevertheless, it has been demonstrated that certain circRNAs can undergo active translation. Therefore, aberrantly expressed circRNAs in
Externí odkaz:
https://doaj.org/article/aa13b660fd674c718d5106fcd51ebb43
Autor:
Julien Schmidt, Johanna Chiffelle, Marta A. S. Perez, Morgane Magnin, Sara Bobisse, Marion Arnaud, Raphael Genolet, Julien Cesbron, David Barras, Blanca Navarro Rodrigo, Fabrizio Benedetti, Alexandra Michel, Lise Queiroz, Petra Baumgaertner, Philippe Guillaume, Michael Hebeisen, Olivier Michielin, Tu Nguyen-Ngoc, Florian Huber, Melita Irving, Stéphanie Tissot-Renaud, Brian J. Stevenson, Sylvie Rusakiewicz, Denarda Dangaj Laniti, Michal Bassani-Sternberg, Nathalie Rufer, David Gfeller, Lana E. Kandalaft, Daniel E. Speiser, Vincent Zoete, George Coukos, Alexandre Harari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The success of cancer immunotherapy depends in part on the strength of antigen recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) and structural (monomeric pMHC-TCR off-rates) avidities o
Externí odkaz:
https://doaj.org/article/07eeb33e654749ddb84ed54edf7d260f
Autor:
Nagi S. El Saghir, Lana E. Khalil, Joud El Dick, Rula W. Atwani, Nadine Safi, Maya Charafeddine, Ahmad Al-Masri, Bassem N. El Saghir, Maha Chaccour, Arafat Tfayli, Hazem Assi, Jaber Abbas, Zeina Ayoub, Eman Sbaity, Hiba A. Moukadem
Publikováno v:
JCO Global Oncology, Vol , Iss 9 (2023)
PURPOSEAround 50% of patients with breast cancer in low- or middle-income countries are younger than 50 years, a poor prognostic variable. We report the outcome of patients with breast cancer 40 years and younger.METHODSWe reviewed 386 patients with
Externí odkaz:
https://doaj.org/article/c8cccfd6a4d745d48bd6ddb55d5dc5c6
Autor:
Hajer Fritah, Michele Graciotti, Cheryl Lai-Lai Chiang, Anne-Laure Huguenin- Bergenat, Rémy Petremand, Ritaparna Ahmed, Philippe Guillaume, Julien Schmidt, Brian J. Stevenson, David Gfeller, Alexandre Harari, Lana E. Kandalaft
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106288- (2023)
Summary: Antigen selection and prioritization represent crucial determinants of vaccines’ efficacy. Here, we compare two personalized dendritic cell-based vaccination strategies using whole-tumor lysate or neoantigens. Data in mouse and in cancer p
Externí odkaz:
https://doaj.org/article/9001342654b947c8becf2723dc803e5f
Autor:
Hiba A. Moukadem, Ahmad Al Masry, Rula W. Atwani, Firas Kreidieh, Lana E. Khalil, Rita Saroufim, Sarah Daouk, Iman Abou Dalle, Nagi S. El Saghir
Publikováno v:
European Journal of Breast Health, Vol 18, Iss 1, Pp 16-20 (2022)
Objective:Worldwide genetic counseling practices are variable and often not reported in low- and middle-income countries (LMICs). We present the follow-up genetic counseling, breast screening, risk-reducing salpingo-oophorectomy (RRSO) and contralate
Externí odkaz:
https://doaj.org/article/217dab4afb9b426481e9c8a002bc79e9
Autor:
Efthymia-Iliana Matthaiou, Yi Guo, Jaleh Barar, Raphael Sandaltzopoulos, Lana E. Kandalaft, Chunsheng Li, George Coukos, Yadollah Omidi
Publikováno v:
BioImpacts, Vol 12, Iss 1, Pp 65-86 (2022)
Introduction: Tumor endothelial marker 1 (TEM1) is expressed by tumor vascular endothelial cells in various cancers. Methods: Here, we developed poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) PEGylated with polyethylene glycol (PEG) and fun
Externí odkaz:
https://doaj.org/article/070209d9764d4d2a83fad37400193bcc
Autor:
Janos L. Tanyi, Cheryl L.-L. Chiang, Johanna Chiffelle, Anne-Christine Thierry, Petra Baumgartener, Florian Huber, Christine Goepfert, David Tarussio, Stephanie Tissot, Drew A. Torigian, Harvey L. Nisenbaum, Brian J. Stevenson, Hajer Fritah Guiren, Ritaparna Ahmed, Anne-Laure Huguenin-Bergenat, Emese Zsiros, Michal Bassani-Sternberg, Rosemarie Mick, Daniel J. Powell, George Coukos, Alexandre Harari, Lana E. Kandalaft
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract T cells are important for controlling ovarian cancer (OC). We previously demonstrated that combinatorial use of a personalized whole-tumor lysate-pulsed dendritic cell vaccine (OCDC), bevacizumab (Bev), and cyclophosphamide (Cy) elicited neo
Externí odkaz:
https://doaj.org/article/ba1d3a5199c64080b68ad63708532dda
Autor:
Rita Ahmed, Isaac Crespo, Sandra Tuyaerts, Amel Bekkar, Michele Graciotti, Ioannis Xenarios, Lana E. Kandalaft
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2217-2227 (2020)
Dendritic cell (DC)-based vaccines have been largely used in the adjuvant setting for the treatment of cancer, however, despite their proven safety, clinical outcomes still remain modest. In order to improve their efficacy, DC-based vaccines are ofte
Externí odkaz:
https://doaj.org/article/c523921c44ac44bebbc14b920683978a
Autor:
Markus Germann, Nadine Zangger, Marc‐Olivier Sauvain, Christine Sempoux, Amber D Bowler, Pratyaksha Wirapati, Lana E Kandalaft, Mauro Delorenzi, Sabine Tejpar, George Coukos, Freddy Radtke
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract High T‐cell infiltration in colorectal cancer (CRC) correlates with a favorable disease outcome and immunotherapy response. This, however, is only observed in a small subset of CRC patients. A better understanding of the factors influencin
Externí odkaz:
https://doaj.org/article/a10c915fbd5647d0990b67d5709c792c
Autor:
Chakradhar Yakkala, Julien Dagher, Christine Sempoux, Cheryl Lai-Lai Chiang, Alban Denys, Lana E. Kandalaft, Bhanu Koppolu, Rafael Duran
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The emergence of ablative therapies has revolutionized the treatment of inoperable solid tumors. Cryoablation stands out for its uniqueness of operation based on hypothermia, and for its ability to unleash the native tumor antigens, resulting in the
Externí odkaz:
https://doaj.org/article/c3ecacfdf4b54233986700323b8b7eae