Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lana C. Ly"'
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101598- (2022)
Summary: Here, we describe protocols to interrogate the binding of the zinc fingers of the transcription factor ZBTB7A to the fetal γ-globin (HBG) promoter. We detail the steps for performing electrophoretic mobility shift assays (EMSAs), X-ray crys
Externí odkaz:
https://doaj.org/article/30f5e92c03a14e44842c76728ad42f58
Autor:
Yang Yang, Ren Ren, Lana C. Ly, John R. Horton, Fudong Li, Kate G.R. Quinlan, Merlin Crossley, Yunyu Shi, Xiaodong Cheng
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109759- (2021)
Summary: Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF, bind directly to the fetal globin promoter elements positioned at
Externí odkaz:
https://doaj.org/article/278a9d06804e4cee8c530abe483c04e3
Autor:
Sarah K. Topfer, Ruopeng Feng, Peng Huang, Lana C. Ly, Gabriella E. Martyn, Gerd A. Blobel, Mitchell J. Weiss, Kate G. R. Quinlan, Merlin Crossley
Publikováno v:
Blood
The benign condition hereditary persistence of fetal hemoglobin (HPFH) is known to ameliorate symptoms of co-inherited β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. The condition is sometimes associated with point mutations i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275b009cc6842377a9dda9d575b4a7fb
https://europepmc.org/articles/PMC8990374/
https://europepmc.org/articles/PMC8990374/
Autor:
Fudong Li, John R. Horton, Lana C. Ly, Merlin Crossley, Kate G. R. Quinlan, Yang Yang, Xiaodong Cheng, Ren Ren, Yunyu Shi
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109759-(2021)
Cell reports
Cell reports
SUMMARY Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF, bind directly to the fetal globin promoter elements positioned at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ddebccc322e5ac940815d1c7370920
https://doi.org/10.1016/j.celrep.2021.109759
https://doi.org/10.1016/j.celrep.2021.109759
Autor:
Nicholas Aboreden, Merlin Crossley, Ren Ren, Thiyagaraj Mayuranathan, Xianjiang Lan, Jeremy D. Grevet, Osheiza Abdulmalik, Kunhua Qin, Yemin Lan, Cheryl A. Keller, Gerd A. Blobel, Zhe Zhang, Mitchell J. Weiss, John R. Horton, Ruopeng Feng, Xiaodong Cheng, Belinda Giardine, Junwei Shi, Ross C. Hardison, Lana C. Ly
Publikováno v:
Mol Cell
Transcription factors typically regulate a large number of genes. Here we found that transcription factor ZNF410 binds and activates the expression of a single direct target gene, CHD4, to enforce the silencing of the fetal hemoglobin genes (HBG1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6372c6e0d4ee7a67499645dd714ae0f
https://doi.org/10.1182/blood-2020-137564
https://doi.org/10.1182/blood-2020-137564