Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lan-ya Li"'
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic constitutes a serious public health concern worldwide. Currently, more than 6 million deaths have occurred despite drastic containment measures, and this number is still increasing. Cu
Externí odkaz:
https://doaj.org/article/959d5acc9bf54ab78d95d144671d5824
Autor:
Hai-Zhou Wu, Lan-Ya Li, Shi-Long Jiang, Yi-Zhi Li, Xiao-Mei Shi, Xin-Yuan Sun, Zhuo Li, Yan Cheng
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
BRAF inhibitors are commonly used in targeted therapies for melanoma patients harboring BRAFV600E mutant. Despite the benefit of vemurafenib therapy, acquired resistance during or after treatment remains a major obstacle in BRAFV600E mutant melanoma.
Externí odkaz:
https://doaj.org/article/32a637fa82144f2787d5d06f4ef4eb7b
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression o
Externí odkaz:
https://doaj.org/article/ed52afba1e8a40c8a72ad1497f451630
Autor:
Da Zeng, Yan Cheng, Min Tian, Lan-ya Li, Song-shu Xiao, Hai-zhou Wu, Xin-luan Wang, Yi Zhang, Xi-Sha Chen
Publikováno v:
Acta Pharmacol Sin
Anexelekto (AXL), a member of the TYRO3-AXL-MER (TAM) family of receptor tyrosine kinases (RTK), is overexpressed in varieties of tumor tissues and promotes tumor development by regulating cell proliferation, migration and invasion. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2444943e09b359c369c7cac36651ce30
https://doi.org/10.1038/s41401-020-00546-8
https://doi.org/10.1038/s41401-020-00546-8
Autor:
Dong-Sheng Cao, Xi-Sha Chen, Kuansong Wang, Jin-Ming Yang, Yi-Di Guan, Lan-ya Li, Xin-luan Wang, Yongguang Tao, Yi Zhang, Minghua Wu, Mingzhu Yin, Xin-Yuan Sun, Xingcong Ren, Yan Cheng, Ao-Xue Li
Publikováno v:
Oncogene. 39:6704-6718
Autophagy can protect stressed cancer cell by degradation of damaged proteins and organelles. However, the regulatory mechanisms behind this cellular process remain incompletely understood. Here, we demonstrate that RSK2 (p90 ribosomal S6 kinase 2) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b663896f0dd0160190d0876c9b5998e
https://doi.org/10.1038/s41388-020-01447-0
https://doi.org/10.1038/s41388-020-01447-0
Autor:
Chong Liu, HanXue Huang, Zhao-Qian Liu, Zhi-Bin Wang, Yan Cheng, Jiang-Feng Fei, Xi-Sha Chen, Shi-long Jiang, Lan-ya Li, Ting Jiang
Publikováno v:
Chemico-biological interactions. 351
Our recent study demonstrated eIF3a loss contributes to vemurafenib resistance in melanoma by activating ERK. However, overexpression of eIF3a in the clinic is not feasible to produce vemurafenib re-sensitization, and ERK inhibitors combined with vem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45011bf0b4a2fe1ad6e8da2a977f40d4
https://pubmed.ncbi.nlm.nih.gov/34813779
https://pubmed.ncbi.nlm.nih.gov/34813779
Autor:
Ceshi Chen, Xingcong Ren, Yi-Di Guan, Wei Guo, Hai-yan Wang, Kuansong Wang, Xi-Sha Chen, Jin-Ming Yang, Pian Yu, Lan-ya Li, Yan Cheng, Xin-Yuan Sun, Bo-Ni Ding, Yi Zhang, Yuan-Chao Ye, Yongguang Tao, Mingzhu Yin
Publikováno v:
Theranostics
Purpose: To determine the role of UCH-L1 in regulating ERα expression, and to evaluate whether therapeutic targeting of UCH-L1 can enhance the efficacy of anti-estrogen therapy against breast cancer with loss or reduction of ERα. Methods: Expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00586390fadbbc1c3dea2bb8e874072b
https://pubmed.ncbi.nlm.nih.gov/32042339
https://pubmed.ncbi.nlm.nih.gov/32042339
Autor:
Yaxin Cheng, Yoshinori Takahashi, Guohui Wan, Harold A. Harvey, Shan Y, Jin Ming Yang, Jason Liao, David Liu, Xingcong Ren, Xi-Sha Chen, Yang Jw, Lan-ya Li, A. F. Chen, Li Zhang, Y. Yuan, Alexey G. Ryazanov, Gavin P. Robertson, Yongguang Tao, Li Y, Han B
Publikováno v:
Oncogene. 35:6293-6308
Cancer cells predominantly metabolize glucose by glycolysis to produce energy in order to meet their metabolic requirement, a phenomenon known as Warburg effect. Although Warburg effect is considered a peculiarity critical for survival and proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0150426ec7494331810fbef8c82c6a4
https://doi.org/10.1038/onc.2016.166
https://doi.org/10.1038/onc.2016.166
Publikováno v:
World Journal of Acupuncture - Moxibustion. 24:49-53
Objective To explore the effectiveness of applying scalp acupuncture in treating child cerebral palsy. Method Computer was adopt to retrieve relevant literature about scalp acupuncture based therapy in treating children cerebral palsy published durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71fe3f53d95b93d8c36a23efbde06fbb
https://doi.org/10.1016/s1003-5257(15)60012-5
https://doi.org/10.1016/s1003-5257(15)60012-5
Autor:
Yan Cheng, Lan-ya Li, Feng Li, Aimin Qiao, Xi-Sha Chen, Yunsheng Yuan, Xingcong Ren, Jianda Zhou, Jin Ming Yang, Kuansong Wang, Yi-Di Guan, Alex F. Chen
Publikováno v:
Oncotarget. 7(28)
Sirt3, a mitochondrial deacetylase, participates in the regulation of multiple cellular processes through its effect on protein acetylation. The objective of this study was to explore the role of Sirt3 in the mitochondrial autophagy (mitophagy), a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3364c1603fcf485bc42ad2435ffdad0
https://pubmed.ncbi.nlm.nih.gov/29930768
https://pubmed.ncbi.nlm.nih.gov/29930768