Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lan-Chun Tu"'
Autor:
Ji-Wang Chern, Sheau Farn Yeh, Lan-Chun Tu, Chia-Ching Liaw, Yao Haur Kuo, Chun-Ling Lin, Yao-To Chang, Ya-Ching Shen
Publikováno v:
Marine Drugs, Vol 9, Iss 2, Pp 256-277 (2011)
A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-b-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines. A
Externí odkaz:
https://doaj.org/article/019d251a64654ab6b83e93f77d1db8b7
Autor:
Karumanchi V. Rao, Vamsi L M Madgula, Jiangnan Peng, Babu L. Tekwani, Mark T. Hamann, Sivaprakasam Prasanna, Melissa R. Jacob, Jürg Gertsch, Robert J. Doerksen, Sucheta Kudrimoti, Shabana Khan, Alejandro M. S. Mayer, Bin Wang, Srinivas Odde, Lan Chun Tu, Hari K. Pennaka, Yeun-Mun Choo
Publikováno v:
Journal of Medicinal Chemistry. 53:61-76
Structure-activity relationship studies were carried out by chemical modification of manzamine A (1), 8-hydroxymanzamine A (2), manzamine F (14), and ircinal isolated from the sponge Acanthostrongylophora. The derived analogues were evaluated for ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792bf9c3b7bc78db6d9c328294cc1e66
https://doi.org/10.1021/jm900672t
https://doi.org/10.1021/jm900672t
Autor:
Lan Chun Tu, Ji-Wang Chern, Sheau Farn Yeh, Chi Hung Lin, Chien Shu Chen, I-Ching Hsiao, Ya-Ching Shen
Publikováno v:
Chemistry & Biology. 12:1317-1324
SummaryMana-Hox, an analog of β-carbolines with anticancer activity, induces aberrant mitosis and delays mitotic exit. However, the cellular target is not known. In this study, we visualized the intracellular localization of Mana-Hox. Mana-Hox rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3f5ca3b1c56a5db42c1ae887e96e43
https://doi.org/10.1016/j.chembiol.2005.09.014
https://doi.org/10.1016/j.chembiol.2005.09.014
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1672:148-156
Mana-Hox is a synthetic analog of manzamines, which are β-carboline alkaloids isolated from marine sponges. Mana-Hox exhibited cytotoxicity against various tumor cell lines with the IC50 range from 1 to 5 μM. Cell cycle synchronization and flow cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9798e9d39e0883107c2485c452895f2
https://doi.org/10.1016/j.bbagen.2004.03.007
https://doi.org/10.1016/j.bbagen.2004.03.007
Publikováno v:
Molecular and Biochemical Parasitology. 129:69-77
Due to trans-splicing and polycistronic transcription, the 5' end structure of precursor RNAs of protein coding genes in Trypanosoma brucei has not yet been characterized. In eukaryotes, in general, the 5' ends of transcripts generated by RNA polymer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e66c684cc3a3de72270421d26013d97
https://doi.org/10.1016/s0166-6851(03)00095-1
https://doi.org/10.1016/s0166-6851(03)00095-1
Publikováno v:
Journal of Biomedical Science. 8:184-190
Treatment of cultured human hepatoma HepG2 cells with the protein kinase C (PKC) activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), results in an increase in tyrosine phosphorylation of several proteins, including the focal adhesion kinase (FAK)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e504437a63127224a17df08f99d50b36
https://doi.org/10.1007/bf02256411
https://doi.org/10.1007/bf02256411
Autor:
Yao-Haur Kuo, Sheau Farn Yeh, Lan-Chun Tu, Ji-Wang Chern, Chia-Ching Liaw, Chun-Ling Lin, Ya-Ching Shen, Yao-To Chang
Publikováno v:
Marine Drugs; Volume 9; Issue 2; Pages: 256-277
Marine Drugs
Marine Drugs, Vol 9, Iss 2, Pp 256-277 (2011)
Marine Drugs
Marine Drugs, Vol 9, Iss 2, Pp 256-277 (2011)
A series of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-β-carboline analogs have been synthesized and evaluated for antitumor activity against human tumor cells including KB, DLD, NCI-H661, Hepa, and HepG2/A2 cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bee5361c6238b2a59738f292abbf393
Publikováno v:
Current stem cell researchtherapy. 4(2)
Cancer stem cells (CSC), also called tumor initiating cells (TIC), are considered to be the origin of replicating malignant tumor cells in a variety of human cancers. Their presence in the tumor may herald malignancy potential, mediate resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f523a9057fa70f9a32d304d16c8bddf1
https://pubmed.ncbi.nlm.nih.gov/19442199
https://pubmed.ncbi.nlm.nih.gov/19442199
Autor:
Shujie Xia, Runsheng Li, Bang Ming Han, Angelita G. Utleg, Jian Wang, Wei Li, Biaoyang Lin, Lan Chun Tu, Yan Guo, Leroy Hood, Xiaowei Yan
Expressed prostatic secretions (EPS) contain proteins of prostate origin that may reflect the health status of the prostate and be used as diagnostic markers for prostate diseases including prostatitis, benign prostatic hyperplasia, and prostate canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82166ab2893d0da98de5a269be75a1a4
https://europepmc.org/articles/PMC2886281/
https://europepmc.org/articles/PMC2886281/
Publikováno v:
Molecularcellular proteomics : MCP. 6(4)
NDRG1 is known to play important roles in both androgen-induced cell differentiation and inhibition of prostate cancer metastasis. However, the proteins associated with NDRG1 function are not fully enumerated. Using coimmunoprecipitation and mass spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52a7be8d9028a8c1c882ea132467575
https://pubmed.ncbi.nlm.nih.gov/17220478
https://pubmed.ncbi.nlm.nih.gov/17220478