Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lan Wei-LaPierre"'
Autor:
Wenxuan Liu, Alanna Klose, Sophie Forman, Nicole D Paris, Lan Wei-LaPierre, Mariela Cortés-Lopéz, Aidi Tan, Morgan Flaherty, Pedro Miura, Robert T Dirksen, Joe V Chakkalakal
Publikováno v:
eLife, Vol 6 (2017)
Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in respon
Externí odkaz:
https://doaj.org/article/378451325042469199ba48d1d765b206
Publikováno v:
eLife, Vol 4 (2015)
Skeletal muscle maintenance depends on motor innervation at neuromuscular junctions (NMJs). Multiple mechanisms contribute to NMJ repair and maintenance; however muscle stem cells (satellite cells, SCs), are deemed to have little impact on these proc
Externí odkaz:
https://doaj.org/article/f8cf9b2fb9f048079c02b9861506a7ac
Autor:
Zhihua Feng, Chien-Ping Ko, Jeong-Ki Kim, Umrao R. Monani, Claudia A. Chiriboga, Lan Wei-LaPierre, Robert T. Dirksen, Michelle R. Faleiro, Narendra Nath Jha
Publikováno v:
J Clin Invest
Paucity of the survival motor neuron (SMN) protein triggers the oft-fatal infantile-onset motor neuron disorder, spinal muscular atrophy (SMA). Augmenting the protein is one means of treating SMA and recently led to FDA approval of an intrathecally d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aee941616068cdb0df6f0f74ead5027
https://doi.org/10.1172/jci131989
https://doi.org/10.1172/jci131989
Publikováno v:
Archives of Biochemistry and Biophysics. 665:122-131
Mitochondrial flashes (mitoflashes) are stochastic events in the mitochondrial matrix detected by mitochondrial-targeted cpYFP (mt-cpYFP). Mitoflashes are quantal bursts of reactive oxygen species (ROS) production accompanied by modest matrix alkalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6330608a34dbe8477cf851a20002e925
https://doi.org/10.1016/j.abb.2019.03.003
https://doi.org/10.1016/j.abb.2019.03.003
Autor:
Robert T. Dirksen, Lan Wei-LaPierre
Publikováno v:
The Journal of General Physiology
Respiring mitochondria undergo an intermittent electrical and chemical excitation called mitochondrial flash (mitoflash), which transiently uncouples mitochondrial respiration from ATP production. How a mitoflash is generated and what specific role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71694bab4916074c27e382990979325
http://europepmc.org/articles/PMC6571996
http://europepmc.org/articles/PMC6571996
Publikováno v:
The Journal of general physiology. 154(9)
The inhibitor of store-operated Ca2+ entry (SOCE) BTP2 was reported to inhibit ryanodine receptor Ca2+ leak and electrically evoked Ca2+ release from the sarcoplasmic reticulum when introduced into mechanically skinned muscle fibers. However, it is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0703615e389fd4f223a0a5d07b65ddd5
https://pubmed.ncbi.nlm.nih.gov/34910094
https://pubmed.ncbi.nlm.nih.gov/34910094
Autor:
David A. Patten, Lan Wei-Lapierre, Fiona McMurray, Robert T. Dirksen, Skye McBride, Megan Macfarlane, Mary-Ellen Harper, X. Qiu
Mitochondrial reactive oxygen species (ROS) are important cellular signaling molecules, but can cause oxidative damage if not kept within tolerable limits. An important proximal form of ROS in mitochondria is superoxide. Its production is thought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19498cf2dd286b0ccacc7458aac67783
https://europepmc.org/articles/PMC6377836/
https://europepmc.org/articles/PMC6377836/
Autor:
Antonio Michelucci, Robert T. Dirksen, Stephanie Brennan, Lan Wei LaPierre, Linda Groom, Maricela García-Castañeda, Nesrin Sabha, James J. Dowling, Sundeep Malik
Publikováno v:
Hum Mol Genet
Ryanodine receptor type I (RYR1)-related myopathies (RYR1 RM) are a clinically and histopathologically heterogeneous group of conditions that represent the most common subtype of childhood onset non-dystrophic muscle disorders. There are no treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42fb87047f11ba1ffd6da4656376fe92
http://hdl.handle.net/11391/1517029
http://hdl.handle.net/11391/1517029
Autor:
Robert T. Dirksen, Wang Wang, Heping Cheng, Shey-Shing Sheu, Xianhua Wang, Lan Wei-LaPierre, Guohua Gong
Publikováno v:
Antioxidants & Redox Signaling
Significance: Recent breakthroughs in mitochondrial research have advanced, reshaped, and revolutionized our view of the role of mitochondria in health and disease. These discoveries include the development of novel tools to probe mitochondrial biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3138da97d9bdb6d911a03d266514603d
https://doi.org/10.1089/ars.2016.6739
https://doi.org/10.1089/ars.2016.6739
Autor:
Eric Rousseau, Lan Wei-LaPierre, Jean Lainé, Patrice Bouchard, Feliciano Protasi, Fatou Touré, Stephanie Nadeau, Camille Hébert, Cedric R. Lamboley, Louiza Yaddaden, Paul C. Pape, Robert T. Dirksen, Jérôme Frenette, Sandrine A. Kake Guena
Publikováno v:
The Journal of General Physiology
The concentration of total calcium in a skeletal muscle appears to be correlated with the muscle’s likely force requirements given by the ratio of body weight to muscle weight.
We describe a new method for determining the concentration of tota
We describe a new method for determining the concentration of tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de97476854191cef5f0d43df18ba4337
https://doi.org/10.1085/jgp.201411250
https://doi.org/10.1085/jgp.201411250