Zobrazeno 1 - 10
of 1 004
pro vyhledávání: '"Lan TAN"'
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background As a currently incurable but preventable disease, the prevention and early diagnosis of Alzheimer’s disease (AD) has long been a research hotspot. Amyloid deposition has been shown to be a major pathological feature of AD. Notab
Externí odkaz:
https://doaj.org/article/b27120ff77324f2c9c7c3b3fa0b89142
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Microglial activation has been suggested to be involved in the pathogenesis of depression and Alzheimer’s disease (AD). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a marker of microglial activation. The
Externí odkaz:
https://doaj.org/article/b2faf9b562404c63b8bb1bba48f47be1
Autor:
Liu Yang, Ya-Nan Ou, Bang-Sheng Wu, Wei-Shi Liu, Yue-Ting Deng, Xiao-Yu He, Yi-Lin Chen, Jujiao Kang, Chen-Jie Fei, Ying Zhu, Lan Tan, Qiang Dong, Jianfeng Feng, Wei Cheng, Jin-Tai Yu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 unique genes in 35 IMDs, among whic
Externí odkaz:
https://doaj.org/article/0382ad71c24141108a559c2764251661
Autor:
Weikang Gong, Yan Fu, Bang-Sheng Wu, Jingnan Du, Liu Yang, Ya-Ru Zhang, Shi-Dong Chen, JuJiao Kang, Ying Mao, Qiang Dong, Lan Tan, Jianfeng Feng, Wei Cheng, Jin-Tai Yu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Iron plays a fundamental role in multiple brain disorders. However, the genetic underpinnings of brain iron and its implications for these disorders are still lacking. Here, we conduct an exome-wide association analysis of brain iron, measur
Externí odkaz:
https://doaj.org/article/7500d4213dad4a99afb9f86430992acc
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
ObjectiveTo investigate the associations between comorbidities and multimorbidity patterns with motor and neuropsychiatric symptoms in patients with Parkinson’s disease (PD) in prodromal PD.MethodsMultimorbidity is defined as the coexistence of two
Externí odkaz:
https://doaj.org/article/1e8a2fd0d16f478594a2deecede7d069
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
BackgroundThe relationship of systolic blood pressure variability (SBPV) with Alzheimer’s disease (AD) remains controversial. We aimed to explore the roles of SBPV in predicting AD incidence and to test the pathways that mediated the relationship o
Externí odkaz:
https://doaj.org/article/698a0f856fe04f129490033a6d4a566d
Autor:
Pei-Yang Gao, Ling-Zhi Ma, Xue-Jie Wang, Bang-Sheng Wu, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Nan Ou, Jian-Feng Feng, Wei Cheng, Lan Tan, Jin-Tai Yu
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical frailty, genetic risk, and dement
Externí odkaz:
https://doaj.org/article/02f56ebedb084e8c864ec7a7115c0e9e
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Sleep disorders are a prevalent non-motor symptom of Parkinson’s disease (PD), although reliable biological markers are presently lacking. Objectives To explore the associations between sleep disorders and serum neurofilament li
Externí odkaz:
https://doaj.org/article/e19e2d5ae930496f88baa8a6efb19441
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background It has been reported that the risk of Alzheimer’s disease (AD) could be predicted by the Australian National University Alzheimer Disease Risk Index (ANU-ADRI) scores. However, among non-demented Chinese adults, the correlations
Externí odkaz:
https://doaj.org/article/fbe333dd0d174aa0a8b76ad15e5b8ea1
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionIncreasing evidence suggests that air pollution has a significant impact on the development of synucleinopathies, but the potential neurobiological mechanisms are unknown. We aimed to explore the associations of air pollution (including o
Externí odkaz:
https://doaj.org/article/a75b644e64c44ad6b4965f1ef78c8ef9