Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lan M, Pham"'
Autor:
Allister Fraser, Kevin R. Shreder, Junichi Ishiyama, John W. Kozarich, Yi Hu, Yasushi Kohno, Heidi E. Brown, Lingling Du, Eric Okerberg, Christopher M. Amantea, Julia Cajica, Emme C.K. Lin, Lan M. Pham
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1553-1556
AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn2+-dependent, 27 nM inhibitor of human plasma Lp-PLA2. Structure–activity relationship studies focused on the AX10479 2-phenylamide gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c315b99f9891368e7cffabc5de59502a
https://doi.org/10.1016/j.bmcl.2012.11.048
https://doi.org/10.1016/j.bmcl.2012.11.048
Autor:
Eric Okerberg, Julia Cajica, Kevin R. Shreder, Yasushi Kohno, Lan M. Pham, Heidi E. Brown, Junichi Ishiyama, Yi Hu, John W. Kozarich, Allister Fraser, Lingling Du, Emme C.K. Lin, Christopher M. Amantea
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:868-871
AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100 nM inhibitor of Lp-PLA2. However, in the presence of EDTA the inhibitory activity of AX10185 was extinguished while the enzymatic activity of Lp-PLA2 did not change. Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de185b106366a37c0bc14bd62e17a668
https://doi.org/10.1016/j.bmcl.2011.12.045
https://doi.org/10.1016/j.bmcl.2011.12.045
Autor:
Yi, Hu, Emme C K, Lin, Lan M, Pham, Julia, Cajica, Christopher M, Amantea, Eric, Okerberg, Heidi E, Brown, Allister, Fraser, Lingling, Du, Yasushi, Kohno, Junichi, Ishiyama, John W, Kozarich, Kevin R, Shreder
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn(2+)-dependent, 27nM inhibitor of human plasma Lp-PLA(2). Structure-activity relationship studies focused on the AX10479 2-phenylamide gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b34b44aa3a62c9cf8f531166843fd435
https://pubmed.ncbi.nlm.nih.gov/23333209
https://pubmed.ncbi.nlm.nih.gov/23333209
Autor:
Kevin R. Shreder, Jonathan S. Rosenblum, Allister Fraser, Ethel McGee, Christopher M. Amantea, Yi Hu, Emme C.K. Lin, Lan M. Pham, John W. Kozarich, Heidi E. Brown, De Michael Chung, Jiangyue Wu, Julia Cajica, Eric Okerberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
KIAA1363 is a serine hydrolase whose activity has been shown to be positively associated with tumor cell invasiveness. Thus, inhibitors of KIAA1363 represent a novel targeted therapy approach towards cancer. AX11890 ((1-bromo-2-naphthyl) N,N-dimethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c4de3cd2c577bc674e8522279d5de
https://pubmed.ncbi.nlm.nih.gov/22877630
https://pubmed.ncbi.nlm.nih.gov/22877630