PP01.34 Induction of Tertiary Lymphoid Structures in Non-Small Cell Lung Cancer Improves B and T Cell Anti-Tumor Immunity

Autor: Mi Kim, H., Liu, D., Ruffin, A., McDonough, A., Lampenfeld, C., Kunning, S., Somasundaram, A., Stabile, L., Bruno, T.

Publikováno v: In Journal of Thoracic Oncology March 2023 18(3) Supplement:e24-e25

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Bifurcated monocyte states are predictive of mortality in severe COVID-19.

Autor: Cillo AR; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA., Somasundaram A; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA., Shan F; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA.; Integrative Systems Biology (ISB) Graduate Program, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USA., Cardello C; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA., Workman CJ; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA., Kitsios GD; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA., Ruffin A; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA.; Graduate Program of Microbiology and Immunology (PMI), University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USA., Kunning S; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA., Lampenfeld C; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA., Onkar S; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA.; Graduate Program of Microbiology and Immunology (PMI), University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USA., Grebinoski S; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA.; Graduate Program of Microbiology and Immunology (PMI), University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USA., Deshmukh G; Meso Scale Discovery, A division of Meso Scale Diagnostics, LLC, 1601 Research Boulevard, Rockville, MD 20850-3173, USA., Methe B; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA., Liu C; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA., Nambulli S; Center for Vaccine Research, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA., Andrews L; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA., Duprex WP; Center for Vaccine Research, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA., Joglekar AV; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Center for Systems Immunology, Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA., Benos PV; Department of Computer Science, University of Pittsburgh, 4200 Fifth Avenue, Pittsburgh, PA 15260, USA.; Department of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA 15213, USA., Ray P; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; University of Pittsburgh Asthma Institute at the University of Pittsburgh Medical Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Ray A; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; University of Pittsburgh Asthma Institute at the University of Pittsburgh Medical Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., McVerry BJ; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA., Zhang Y; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA., Lee JS; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA.; Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Das J; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Center for Systems Immunology, Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA., Singh H; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Center for Systems Immunology, Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA., Morris A; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15213, USA., Bruno TC; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA., Vignali DAA; Department of Immunology, School of Medicine, University of Pittsburgh. Pittsburgh, PA 15260, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center. Pittsburgh, PA 15232, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15232, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Feb 10. Date of Electronic Publication: 2021 Feb 10.