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Akademický článek

Comparison of the CYP3A Selective Inhibitors CYP3cide, Clobetasol, and Azamulin for Their Potential to Distinguish CYP3A7 Activity in the Presence of CYP3A4/5.

Autor: Work HM; Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado (H.M.W., S.E.K., J.N.L.)., Kandel SE; Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado (H.M.W., S.E.K., J.N.L.)., Lampe JN; Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado (H.M.W., S.E.K., J.N.L.) jed.lampe@cuanschutz.edu.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Oct 16; Vol. 52 (11), pp. 1224-1233. Date of Electronic Publication: 2024 Oct 16.

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Akademický článek

Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1.

Autor: Kandel SE; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, Colorado, USA., Tooker BC; Pulmonary Division, Department of Medicine, National Jewish Health, Denver, Colorado, USA., Lampe JN; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, Colorado, USA. Electronic address: jed.lampe@cuanschutz.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Aug; Vol. 300 (8), pp. 107594. Date of Electronic Publication: 2024 Jul 18.

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Akademický článek

HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation.

Autor: Work HM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado (H.M.W., J.N.L.); and Biomolecular Sciences Institute & Department of Chemistry & Biochemistry, School of Integrated Science & Humanity, College of Arts, Sciences, & Education, Florida International University, Miami, Florida (J.C.H.)., Hackett JC; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado (H.M.W., J.N.L.); and Biomolecular Sciences Institute & Department of Chemistry & Biochemistry, School of Integrated Science & Humanity, College of Arts, Sciences, & Education, Florida International University, Miami, Florida (J.C.H.)., Lampe JN; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado (H.M.W., J.N.L.); and Biomolecular Sciences Institute & Department of Chemistry & Biochemistry, School of Integrated Science & Humanity, College of Arts, Sciences, & Education, Florida International University, Miami, Florida (J.C.H.) jed.lampe@cuanschutz.edu.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 May 16; Vol. 52 (6), pp. 516-525. Date of Electronic Publication: 2024 May 16.

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Akademický článek

Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach.

Autor: Kandel SE; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, Colorado 80045, United States., Gracey EG; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, Colorado 80045, United States., Lampe JN; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, Colorado 80045, United States.

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2023 Oct 16; Vol. 36 (10), pp. 1631-1642. Date of Electronic Publication: 2023 Sep 28.

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Correction: Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate.

Autor: Liu J, Kandel SE, Lampe JN, Scott EE

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Oct; Vol. 299 (10), pp. 105283. Date of Electronic Publication: 2023 Sep 30.

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Akademický článek

Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate.

Autor: Liu J; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA., Kandel SE; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA., Lampe JN; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA., Scott EE; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA; Departments of Pharmacology, Biological Chemistry and Programs in Chemical Biology and Biophysics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: scottee@umich.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Aug; Vol. 299 (8), pp. 104993. Date of Electronic Publication: 2023 Jun 29.

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