P18 WVE-N531 with PN backbone modification significantly enhances drug concentrations in heart, diaphragm, and skeletal muscles in non-human primates

Autor: Hart, A., Hu, X., Lamore, S.

Publikováno v: In Neuromuscular Disorders October 2023 33 Supplement 1:S101-S102

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Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment of C9orf72 -associated ALS or FTD.

Autor: Liu Y; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Andreucci A; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Iwamoto N; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Yin Y; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Yang H; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Liu F; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Bulychev A; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Hu XS; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Lin X; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Lamore S; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Patil S; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Mohapatra S; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Purcell-Estabrook E; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Taborn K; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Dale E; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA., Vargeese C; Wave Life Sciences, 733 Concord Avenue, Cambridge, MA 02138, USA.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2022 Apr 20; Vol. 28, pp. 558-570. Date of Electronic Publication: 2022 Apr 20 (Print Publication: 2022).

Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.

Autor: Halkina T; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Henderson JL; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Lin EY; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Himmelbauer MK; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Jones JH; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Nevalainen M; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Feng J; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., King K; Department of Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Rooney M; Department of Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Johnson JL; Department of Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Marcotte DJ; Department of Physical Biochemistry and Molecular Design, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Chodaparambil JV; Department of Physical Biochemistry and Molecular Design, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Kumar PR; Department of Physical Biochemistry and Molecular Design, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Patterson TA; Department of Physical Biochemistry and Molecular Design, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Murugan P; Department of Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Schuman E; Department of Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Wong L; Department of Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hesson T; Department of Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Lamore S; Department of Preclinical Safety, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bao C; Department of Emerging Neurosciences Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Calhoun M; Department of Emerging Neurosciences Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Certo H; Department of Emerging Neurosciences Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Amaral B; Department of Emerging Neurosciences Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Dillon GM; Department of Emerging Neurosciences Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gilfillan R; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., de Turiso FG; Department of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6358-6380. Date of Electronic Publication: 2021 May 04.

Antioxidant and anti-inflammatory effects of Cinnamomum species and their bioactive compounds: An updated review of the molecular mechanisms.

Autor: Davoudi, Farzaneh¹, Ramazani, Elham² el.ramazani@um.ac.ir

Publikováno v: Physiology & Pharmacology. Jul2024, Vol. 28 Issue 2, p99-116. 18p.