Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lamont Booker"'
Autor:
Thomas Ingersoll, Stephanie Cole, Janna Madren-Whalley, Lamont Booker, Russell Dorsey, Albert Li, Harry Salem
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152985 (2016)
Integrated Discrete Multiple Organ Co-culture (IDMOC) is emerging as an in-vitro alternative to in-vivo animal models for pharmacology studies. IDMOC allows dose-response relationships to be investigated at the tissue and organoid levels, yet, these
Externí odkaz:
https://doaj.org/article/e21c69b685234beb929cd2f436cd0d49
Autor:
Lamont Booker, Diane M Hildenberger, Susan M. DeLeon, Melissa O Rhoomes, Gary A. Rockwood, Jason D. Downey, Kelly A. Basi
Publikováno v:
Clinical toxicology (Philadelphia, Pa.). 56(5)
Cyanide (CN) is a metabolic poison, halting ATP synthesis by inhibiting complex IV of the electron transport chain. If exposed at high enough concentrations, humans and most animals can die within minutes. Because time is a crucial factor in survival
Publikováno v:
Toxicology of Cyanides and Cyanogens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50c5d990d3eb2872a8c89b7d1af7f169
https://doi.org/10.1002/9781118628966.ch1
https://doi.org/10.1002/9781118628966.ch1
Autor:
Stephanie Cole, Russell M. Dorsey, Harry Salem, Lamont Booker, Janna S. Madren-Whalley, Thomas Ingersoll, Albert P. Li
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152985 (2016)
PLoS ONE
PLoS ONE
Integrated Discrete Multiple Organ Co-culture (IDMOC) is emerging as an in-vitro alternative to in-vivo animal models for pharmacology studies. IDMOC allows dose-response relationships to be investigated at the tissue and organoid levels, yet, these
Autor:
Jacqueline L. Blankman, Dale L. Boger, Steven G. Kinsey, Aron H. Lichtman, Benjamin F. Cravatt, Rehab A. Abdullah, Lamont Booker, Jonathan Z. Long, Cyrine Ezzili
Publikováno v:
British Journal of Pharmacology. 165:2485-2496
BACKGROUND AND PURPOSE Inflammatory pain presents a problem of clinical relevance and often elicits allodynia, a condition in which non-noxious stimuli are perceived as painful. One potential target to treat inflammatory pain is the endogenous cannab
Autor:
Dana E. Selley, Bin Pan, Aron H. Lichtman, Elizabeth A. Thomas, Qing-song Liu, Daniel K. Nomura, Benjamin F. Cravatt, Steven G. Kinsey, Jacqueline L. Blankman, Peter T. Nguyen, Divya Ramesh, Joel E. Schlosburg, Lamont Booker, Laura J. Sim-Selley, Jonathan Z. Long, James J. Burston
Publikováno v:
Nature neuroscience
Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system. Here we show that a similar form of functional antagonism is produced by sustained inactiva
Autor:
Laura J. Sim-Selley, Benjamin F. Cravatt, Aron H. Lichtman, Xin Jin, Lamont Booker, Jenny L. Wiley, Jonathan Z. Long, Robert E. Vann, Daniel K. Nomura, D. Matthew Walentiny, James J. Burston
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20270-20275
Δ 9 -Tetrahydrocannabinol (THC), the psychoactive component of marijuana, and other direct cannabinoid receptor (CB1) agonists produce a number of neurobehavioral effects in mammals that range from the beneficial (analgesia) to the untoward (abuse p
Publikováno v:
Drug and Alcohol Dependence. 105:42-47
Considerable preclinical research has demonstrated the efficacy of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the primary psychoactive constituent of Cannabis sativa, in a wide variety of animal models of pain, but few studies have examined other
Autor:
Loren H. Parsons, Steven G. Kinsey, Franciso J Pavón, Joel E. Schlosburg, Dana E. Selley, Weiwei Li, James J. Burston, Aron H. Lichtman, Benjamin F. Cravatt, Lamont Booker, Jonathan Z. Long, Antonia Serrano
Publikováno v:
Nature chemical biology
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydr
Autor:
Divya Ramesh, Dana E. Selley, Lamont Booker, Benjamin F. Cravatt, Jonathan Z. Long, Rehab A. Abdullah, Joel E. Schlosburg, Steven G. Kinsey, Bogna M. Ignatowska-Jankowska, Qing Tao, Aron H. Lichtman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 350(2)
Complementary genetic and pharmacological approaches to inhibit monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), the primary hydrolytic enzymes of the respective endogenous cannabinoids 2-arachidonoylglycerol (2-AG) and N-arachid