Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Lamont BI"'
2
Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini
Autor: Martin Poe, B. E. Evans, Robert M. DiPardo, Edgar H. Ulm, Kenneth E. Rittle, LaMont Bi, Joshua S. Boger, Lynch Rj, Mark G. Bock, George P. Vlasuk
Publikováno v: Journal of Medicinal Chemistry. 30:1853-1857
A series of statine-containing tetrapeptides, systematically modified at the carboxy terminus with various hydrophobic aromatic groups, is described. These compounds were tested in vitro for their ability to inhibit porcine, human plasma, and purifie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ff585bee2b4ee64a80dc3570ef1642
https://doi.org/10.1021/jm00393a029
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4
Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency
Autor: LaMont Bi, Willie L. Whitter, Payne Linda S, Robert M. DiPardo, Joshua S. Boger, B. E. Evans, Kenneth E. Rittle, Roger M. Freidinger, Edgar H. Ulm, Mark G. Bock
Publikováno v: Journal of medicinal chemistry. 31(10)
Nineteen tetrapeptides containing statine (Sta) and 4-amino-5-cyclohexyl-3-hydroxypentanoic acid (ACHPA) were prepared. Solubility measurements of these compounds were carried out in H2O and in pH 7.4 phosphate buffer solution, and their partition co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e837297dc024ded7187bc66b4fe25b
https://pubmed.ncbi.nlm.nih.gov/3050088
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6
Novel renin inhibitors containing the amino acid statine
Autor: Linda S. Payne, Ted C. Vassil, Tsau-Yen Lin, Daniel H. Rich, Edgar H. Ulm, Edward H. Blaine, Nancy S. Lohr, LaMont Bi, Daniel F. Veber, George M. Fanelli, Inez I. Stabilito, Joshua S. Boger, Amrit S. Bopari, Terry W. Schorn, Martin Poe
Publikováno v: Nature. 303(5912)
The proteolytic enzyme renin (EC3.4.99.19) cleaves the protein substrate angiotensinogen to yield angiotensin I, the decapeptide substrate transformed by converting enzyme into the pressor substance angiotensin II1. Although the contribution of this
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ddb647a48586933bbf4f48095779ce
https://pubmed.ncbi.nlm.nih.gov/6341856
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8
Akademický článek
Renin inhibitors containing 2-substituted statine.
Autor: Veber DF, Bock MG, Brady SF, Ulm EH, Cochran DW, Smith GM, LaMont BI, Dipardo RM, Poe M, Freidinger RM, et. al.
Publikováno v: Biochemical Society transactions [Biochem Soc Trans] 1984 Dec; Vol. 12 (6), pp. 956-9.
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9
Akademický článek
Benzolactams. A new class of converting enzyme inhibitors.
Autor: Parsons WH, Davidson JL, Taub D, Aster SD, Thorsett ED, Patchett AA, Ulm EH, Lamont BI
Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1983 Nov 30; Vol. 117 (1), pp. 108-13.
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10
Akademický článek
Novel renin inhibitors containing the amino acid statine.
Autor: Boger J, Lohr NS, Ulm EH, Poe M, Blaine EH, Fanelli GM, Lin TY, Payne LS, Schorn TW, LaMont BI, Vassil TC, Stabilito II, Veber DF, Rich DH, Bopari AS
Publikováno v: Nature [Nature] 1983 May 5-11; Vol. 303 (5912), pp. 81-4.
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