Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase

Autor: Guzman, JD, Pesnot, T, Barrera, DA, Davies, HM, McMahon, E, Evangelopoulos, D, Mortazavi, PN, Munshi, T, Maitra, A, Lamming, ED, Angell, R, Gershater, MC, Redmond, JM, Needham, D, Ward, JM, Cuca, LE, Hailes, HC, Bhakta, S

Publikováno v: Journal of Antimicrobial Chemotherapy

Objectives \ud \ud (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H37Rv. A biomimetic approach for the chemical synthesis of a wide a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2753b80012373d005ae5e32fe006364a
https://eprints.bbk.ac.uk/id/eprint/11466/7/11466(a).pdf

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.

Autor: Guzman JD; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK., Pesnot T; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK., Barrera DA; Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Colombia., Davies HM; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK., McMahon E; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK., Evangelopoulos D; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK., Mortazavi PN; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK., Munshi T; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK., Maitra A; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK., Lamming ED; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK., Angell R; Drug Discovery Group, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK., Gershater MC; The Advanced Centre for Biochemical Engineering, University College London, Gordon Street, London WC1H 0AH, UK., Redmond JM; Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK., Needham D; Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK., Ward JM; Drug Discovery Group, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK., Cuca LE; Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Colombia., Hailes HC; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK., Bhakta S; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK s.bhakta@bbk.ac.uk sanjib.bhakta@ucl.ac.uk.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2015; Vol. 70 (6), pp. 1691-703. Date of Electronic Publication: 2015 Feb 04.