Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lamia Rhymee"'
Autor:
Victor E. Velculescu, Julie R. Brahmer, Matthew D. Hellmann, Jamie E. Chaft, Drew M. Pardoll, Rachel Karchin, Robert B. Scharpf, Janis Taube, Jennifer L. Sauter, James M. Isbell, Malcolm V. Brock, Edward Gabrielson, Qing Kay Li, Peter Illei, Franco Verde, Christos Georgiades, Josephine Feliciano, Benjamin Levy, Christine L. Hann, Doreen N. Palsgrove, Lamia Rhymee, Tricia R. Cottrell, Kellie N. Smith, Vilmos Adleff, Alessandro Leal, Jillian Phallen, Samuel Rosner, Daniel C. Bruhm, I.K. Ashok Sivakumar, Kristen Marrone, Jarushka Naidoo, Carolyn Hruban, Noushin Niknafs, James R. White, Patrick M. Forde, Valsamo Anagnostou
Despite the initial successes of immunotherapy, there is an urgent clinical need for molecular assays that identify patients more likely to respond. Here, we report that ultrasensitive measures of circulating tumor DNA (ctDNA) and T-cell expansion ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9635a5d6f44ac7214b2e198664dbe1a1
https://doi.org/10.1158/0008-5472.c.6511197.v1
https://doi.org/10.1158/0008-5472.c.6511197.v1
Autor:
Victor E. Velculescu, Julie R. Brahmer, Matthew D. Hellmann, Jamie E. Chaft, Drew M. Pardoll, Rachel Karchin, Robert B. Scharpf, Janis Taube, Jennifer L. Sauter, James M. Isbell, Malcolm V. Brock, Edward Gabrielson, Qing Kay Li, Peter Illei, Franco Verde, Christos Georgiades, Josephine Feliciano, Benjamin Levy, Christine L. Hann, Doreen N. Palsgrove, Lamia Rhymee, Tricia R. Cottrell, Kellie N. Smith, Vilmos Adleff, Alessandro Leal, Jillian Phallen, Samuel Rosner, Daniel C. Bruhm, I.K. Ashok Sivakumar, Kristen Marrone, Jarushka Naidoo, Carolyn Hruban, Noushin Niknafs, James R. White, Patrick M. Forde, Valsamo Anagnostou
Supplementary Table S1. Summary of patient characteristics Supplementary Table S2. Summary of plasma samples analyzed Supplementary Table S3. Summary of peripheral blood lymphocytes and tumor infiltrating lymphocytes samples analyzed Supplementary Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124d0b4bc633214944bd209dff0fdd47
https://doi.org/10.1158/0008-5472.22422375
https://doi.org/10.1158/0008-5472.22422375
Autor:
Victor E. Velculescu, Julie R. Brahmer, Matthew D. Hellmann, Jamie E. Chaft, Drew M. Pardoll, Rachel Karchin, Robert B. Scharpf, Janis Taube, Jennifer L. Sauter, James M. Isbell, Malcolm V. Brock, Edward Gabrielson, Qing Kay Li, Peter Illei, Franco Verde, Christos Georgiades, Josephine Feliciano, Benjamin Levy, Christine L. Hann, Doreen N. Palsgrove, Lamia Rhymee, Tricia R. Cottrell, Kellie N. Smith, Vilmos Adleff, Alessandro Leal, Jillian Phallen, Samuel Rosner, Daniel C. Bruhm, I.K. Ashok Sivakumar, Kristen Marrone, Jarushka Naidoo, Carolyn Hruban, Noushin Niknafs, James R. White, Patrick M. Forde, Valsamo Anagnostou
Supplementary Figure S1. ctDNA clonal dynamics during anti-PD1 for patients with a clinical response. Supplementary Figure S2. ctDNA clonal dynamics during anti-PD1 for patients with molecular primary resistance. Supplementary Figure S3. ctDNA molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2199f2d6c13c6a2a2b5325febf3e282c
https://doi.org/10.1158/0008-5472.22422378.v1
https://doi.org/10.1158/0008-5472.22422378.v1
Autor:
Rachel Karchin, Malcolm V. Brock, Alexander S. Baras, Edward Gabrielson, Daniel C. Bruhm, Joshua E. Reuss, Stephen B. Baylin, Peter B. Illei, Samuel Rosner, Kellie N. Smith, Drew M. Pardoll, Patrick M. Forde, Ferry Lalezari, Josephine Feliciano, Valsamo Anagnostou, Robert B. Scharpf, Noushin Niknafs, Julie R. Brahmer, Victor E. Velculescu, James R. White, Qing Kay Li, Kristen Rodgers, Jarushka Naidoo, Vilmos Adleff, Zineb Belcaid, Christos S. Georgiades, David S. Ettinger, Mara Lanis, Karlijn Hummelink, Benjamin Levy, Kristen A. Marrone, Franco Verde, Christine L. Hann, Lamia Rhymee, Kim Monkhorst
Publikováno v:
Nat Cancer
Despite progress in immunotherapy, identifying patients that respond has remained a challenge. Through analysis of whole-exome and targeted sequence data from 5,449 tumors, we found a significant correlation between tumor mutation burden (TMB) and tu
Autor:
Malcolm V. Brock, Benjamin Levy, Jillian Phallen, Matthew D. Hellmann, Victor E. Velculescu, Doreen N. Palsgrove, I K Ashok Sivakumar, Edward Gabrielson, Qing Kay Li, Christine L. Hann, Lamia Rhymee, Valsamo Anagnostou, Peter B. Illei, Patrick M. Forde, Kristen A. Marrone, Alessandro Leal, Josephine Feliciano, Jarushka Naidoo, Daniel C. Bruhm, Franco Verde, James M. Isbell, James R. White, Carolyn Hruban, Janis M. Taube, Tricia R. Cottrell, Robert B. Scharpf, Vilmos Adleff, Drew M. Pardoll, Julie R. Brahmer, Christos S. Georgiades, Rachel Karchin, Noushin Niknafs, Jennifer L. Sauter, Jamie E. Chaft, Kellie N. Smith, Samuel Rosner
Publikováno v:
Cancer Research. 79:1214-1225
Despite the initial successes of immunotherapy, there is an urgent clinical need for molecular assays that identify patients more likely to respond. Here, we report that ultrasensitive measures of circulating tumor DNA (ctDNA) and T-cell expansion ca
Autor:
Ronan J. Kelly, Julie R. Brahmer, Vincent K. Lam, Jinny Ha, Patrick M. Forde, Ali H. Zaidi, Zineb Belcaid, Stephen Broderick, Jenna Van Liere Canzoniero, Lamia Rhymee, Richard J. Battafarano, David S. Ettinger, Elizabeth D. Thompson, Victor E. Velculescu, Mara Lanis, Kristen A. Marrone, Blair A. Jobe, Stephen C. Yang, Hanika Rodavia, Archana Balan, Blair Landon, Josephine Feliciano, Heather Schneider, Valsamo Anagnostou, Benjamin Levy
Publikováno v:
Cancer Research. 81:538-538
We examined the utility of serial liquid biopsies to monitor clonal dynamics and predict pathologic response in patients with esophageal/gastroesophageal junction (E/GEJ) cancer undergoing treatment with neoadjuvant immunotherapy and concurrent chemo
Autor:
Alessandro Leal, Kristen A. Marrone, Benjamin Levy, Julie R. Brahmer, Hatim Husain, Leonardo Ferreira, Robert B. Scharpf, Patrick M. Forde, Vincent K. Lam, Christine L. Hann, Lamia Rhymee, David S. Ettinger, Joseph C. Murray, Mara Lanis, Victor E. Velculescu, Kim Monkhorst, Peter B. Illei, Valsamo Anagnostou, Qing Kay Li, Josephine Feliciano, Noushin Niknafs, Karlijn Hummelink, James R. White, Jarushka Naidoo, Samuel Rosner
Publikováno v:
Cancer Research. 81:1668-1668
Given the success of immunotherapy (IO), multiple IO-based options exist for advanced non-small cell lung cancer (NSCLC). Currently used biomarkers do not fully predict clinical outcomes and response assessment remains limited to radiological evaluat
Autor:
Kristen A. Marrone, Samuel Rosner, Jenna Van Liere Canzoniero, David S. Ettinger, Alexandria Curry, Benjamin Levy, Julie R. Brahmer, Valsamo Anagnostou, Patrick M. Forde, Mara Lanis, Michael Hwang, Gavin Pereira, Tanguy Seiwert, Guangfan Zhang, Victor E. Velculescu, Joshua E. Reuss, Christine L. Hann, Lamia Rhymee, Vincent K. Lam, Jarushka Naidoo
Publikováno v:
Cancer Research. 81:27-27
Background: Treatment-induced anti-tumor immune response may be reflected in peripheral blood leukocyte composition and shifts. The relative abundance of immune cell subsets captured by neutrophil-to-lymphocyte ratio (NLR) is a promising biomarker of
Autor:
Jarushka Naidoo, Benjamin Levy, Patrick M. Forde, Robert B. Scharpf, David S. Ettinger, Valsamo Anagnostou, Christine L. Hann, Josephine Feliciano, Joseph C. Murray, Victor E. Velculescu, Peter B. Illei, Kristen A. Marrone, Vincent K. Lam, Leonardo Ferreira, Julie R. Brahmer, Samuel Rosner, Mara Lanis, Chenguang Wang, Lamia Rhymee
Publikováno v:
Journal of Clinical Oncology. 38:9525-9525
9525 Background: First-line immunotherapy (IO) and chemo-immunotherapy (chemo-IO) are approved for PD-L1-expressing advanced non-small cell lung cancer (NSCLC), but PD-L1 expression does not reliably predict therapeutic response. Therefore, accurate